Dr. Zhen Zhang is an associate professor of pathology and oncology at the Johns Hopkins University School of Medicine.
Dr. Zhang’s research focus on the design of large-scale discovery studies for biomarkers and other molecular targets, and their translation into clinical applications. He was trained as a quantitative and computational scientists working in pattern recognition, image processing, and artificial intelligence. Through his many years as a faculty member in the Department of Biostatistics, Epidemiology, and Systems Science at MUSC and then at JHU working on developing biomarkers and clinical tests for cancer detection, he has developed a diverse portfolio of research interests and expertise ranging from the development of statistical/computational methods for integrated omics data analysis to design and conducting web-lab experiments to discover, characterize and verify molecular functions of biomarkers and other targets. He designed and conducted a large-scale multi-center discovery study and successfully applied these algorithms and tools to the generated proteomic data and discovered/validated a panel of biomarkers. He then derived a classification algorithm using these biomarkers as part of its input. The result had become the first (with his colleague Daniel Chan) in vitro diagnostic multivariate index assay (IVDMIA) of proteomic biomarkers ever cleared by FDA for clinical use.
At JHU, he is the Associate Director of the Center for Biomarker Discovery and Translation (CBDT). He has been responsible for study design and experimental design in clinical proteomics studies and helped to develop a basic discovery workflow and quality control/assurance requirements that have been used for all discovery work at the Center. Dr. Zhang is a PI of the NCI funded CPTAC (Clinical Proteomic Tumor Analysis Consortium) Center at JHU and the contact PI of the NCI’s Early Detection Research Network (EDRN) Biomarker Development Laboratory. He has been a co-investigator on multiple NCI/EDRN BDL and BRL and a previous CVC.
Dr. Zhang has published over 130 scholarly articles, particularly in the field of bioinformatics and the development of biomarkers and multivariate approaches to improve disease detection.