Zachariah H Foda, M.D., Ph.D.

Headshot of Zachariah H Foda
  • Assistant Professor of Medicine

Expertise

Colon Polyps, Colorectal Cancer Screening, Familial Adenomatous Polyposis, Hereditary Colorectal Cancer, Juvenile Polyposis Syndrome, Lynch Syndrome, Peutz-Jeghers Syndrome, Polyposis Syndrome ...read more

Research Interests

Liquid biopsies; Early detection; Colon cancer risk stratification; Hereditary cancer syndromes ...read more

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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International Patients

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Locations

Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-933-7495
601 N. Caroline St.
7th Floor
Baltimore, MD 21287
Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center) - Google Maps

Johns Hopkins Medicine - White Marsh

Appointment Phone: 443-997-0286
4924 Campbell Boulevard
Suite 250
Nottingham, MD 21236
Johns Hopkins Medicine - White Marsh - Google Maps

Skip Viragh Outpatient Cancer Center

Appointment Phone: 410-502-7082
201 N. Broadway
5th Floor
Baltimore, MD 21287
Skip Viragh Outpatient Cancer Center - Google Maps

Background

Gastroenterologist Zachariah Foda specializes in colon cancer and leads the Johns Hopkins Colon Cancer Risk Assessment Clinic. His areas of expertise include familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer (Lynch syndrome), juvenile polyposis, Peutz-Jeghers syndrome and polyposis syndromes.  

Dr. Foda obtained his medical and postdoctoral degrees at the Renaissance School of Medicine at Stony Brook University. He completed an internal medicine residency at The Johns Hopkins University and remained there for fellowship training in gastroenterology and hepatology.

During his doctoral training, Zachariah Foda studied how protein kinases incorporate signals from regulatory sites, and how to use this integration for therapeutic intervention. These findings provided a potential explanation for treatment failures for cancer, and were important steps in the development of more specific and therefore more useful therapies. His postdoctoral work focused on elucidating the underlying mechanisms of liquid biopsies and using whole genome sequencing based liquid biopsy approaches for early detection of gastrointestinal cancers in patients who are high risk. 

Dr. Foda’s current research interests include liquid biopsies, early detection of gastrointestinal cancers, colon cancer risk stratification and hereditary cancer syndromes. Among his clinical research interests is characterizing cancer risk for patients with multiple polyps.

 

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Titles

  • Assistant Professor of Medicine
  • Instructor of Oncology

Departments / Divisions

Education

Degrees

  • MD; Stony Brook University (2017)

Residencies

  • Internal Medicine; Johns Hopkins University School of Medicine (2019)

Fellowships

  • Gastroenterology and Hepatology; Johns Hopkins University School of Medicine (2022)
  • Gastroenterology; Johns Hopkins University School of Medicine (2022)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (2020)

Research & Publications

Selected Publications

Maianti, JP, McFedries, A, Foda, ZH, Kleiner, RE, Du, XQ, Leissring, MA, Tang, W-J, Charron, MJ, Seeliger, MA, Saghatelian, A, Liu, DR. (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 511, 94-98.

Foda, ZH, and Seeliger, MA. (2014). Kinase inhibitors: An allosteric add-on. Nature Chemical Biology, 10, 796-797.

Foda, ZH, Shan, Y, Kim, ET, Shaw, DE, Seeliger MA. (2015). A dynamically coupled allosteric network underlies binding cooperativity in Src kinase. Nature Communications. 6, 5939.

Lebedev, I, Nemajerova, A, Foda, ZH, Kornaj, M, Tong, M, Moll, UM, & Seeliger, MA (2016). A novel in vitro CypD-mediated p53 aggregation assay suggests a model for mitochondrial permeability transition by chaperone systems. Journal of molecular biology, 428(20), 4154-4167.

Mingione, V. R., Foda, Z. H., Paung, Y., Philipose, H., Rangwala, A. M., Shan, Y., & Seeliger, M. A. (2022). Validation of an Allosteric Binding Site of Src Kinase Identified by Unbiased Ligand Binding Simulations. Journal of Molecular Biology, 167628.

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