Research Summary
My laboratory employs advanced technologies, including (i) high-throughput screening platforms of receptors of prion-like proteins and related inhibitors, (ii) cellular and animal models of prion-like protein transmission, (iii) scanning tunneling microscopy, and (iv) protein misfolding cyclic amplification for strains.
Lab
Lab Website: Xiaobo Mao
Technology Expertise Keywords
Cell and Protein Biology, Biophysics
Clinical Trials
Learn more about clinical trials at Johns Hopkins Medicine.
Selected Publications
Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Goncalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science. 2016 Sep 30;353(6307).
Kam TI#, Mao X#, Park H# (# equal contribution), Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM and Dawson VL. Poly (ADP-ribose) Drives Pathologic α-Synuclein Neurodegeneration in Parkinson’s Disease. Science. 2018;362(6414). doi: 10.1126/science.aat8407.
Mao X, Guo Y, Luo Y, Niu L, Liu L, Ma X, Wang H, Yang Y, Wei G, Wang C. Sequence effects on peptide assembly characteristics observed by using scanning tunneling microscopy. J Am Chem Soc. 2013 Feb 13;135(6):2181-7.
Mao XB, Wang CX, Wu XK, Ma XJ, Liu L, Zhang L, Niu L, Guo YY, Li DH, Yang YL, Wang C. Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19605-10.
Zhang M#, Mao X# (# equal contribution), Wang C, Zeng W, Zhang C, Li Z, Fang Y, Yang Y, Liang W, Wang C. The effect of graphene oxide on conformation change, aggregation and cytotoxicity of HIV-1 regulatory protein (Vpr). Biomaterials. 2013 Jan; 34(4):1383-90.
Patents
A detection method for the relative adsorption constant of dye, antibody, drug and pro-drug molecules on peptides.
Patent # WO2011060598A1 & CN102062718 |
Therapeutic Uses of LAG3 the α-Synuclein Transmission Receptor, Ted M. Dawson, Valina L. Dawson, Han Seok Ko, Xiaobo Mao, Dario Angelo Alberto Vignali, Creg J. Workman.
Patent # WO2018039147A1, PCT/US2017/047878 |
