Skip Navigation

COVID-19: We are vaccinating patients ages 12+. Learn more:

Vaccines, Boosters & 3rd Doses | Testing | Patient Care | Visitor Guidelines | Coronavirus | Self-Checker | Email Alerts

 

Philips Respironics issued a recall for some CPAP and BiLevel PAP devices and mechanical ventilators. Learn more.

Background

Dr. Winston Timp is an associate professor of biomedical engineering at the Whiting School of Engineering and the Johns Hopkins School of Medicine. His research focuses on sequencing technology development. 

His lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Timp’s research integrates the principles of biophysics, molecular biology, and computational biology to create new tools for exploring the epigenomes and genomes of different lifeforms, ranging in size from the flu virus to hummingbirds to California redwoods. Based on the knowledge gained from these studies, Timp and his lab apply their toolsets to clinical samples for the diagnosis, surveillance, and treatment of human disease. Recent projects in Timp’s lab include new sequencing methods to diagnose infectious disease, new methods to characterize RNA biology, and examining single molecule epigenetics of cancer. 

...read more

Titles

  • Joint Appointment in Medicine
  • Joint Appointment in Molecular Biology and Genetics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; Massachusetts Institute of Technology (Massachusetts) (2007)
  • B.S.; University of Illinois (Urbana-Champaign) (Illinois) (2002)

Research & Publications

Research Summary

The Timp lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Timp’s research integrates the principles of biophysics, molecular biology, and computational biology to create new tools for exploring the epigenomes and genomes of different lifeforms, ranging in size from the flu virus to hummingbirds to California redwoods. Based on the knowledge gained from these studies, Timp and his lab apply their toolsets to clinical samples for the diagnosis, surveillance and treatment of human disease. Recent projects in Timp’s lab include new sequencing methods to diagnose infectious disease, new methods to characterize RNA biology, and examining single molecule epigenetics of cancer. 

 

Lab

Lab Website: Timp Lab

Selected Publications

View all on PubMed

J. T. Simpson, R. E. Workman, P. C. Zuzarte, M. David, L. J. Dursi, and W. Timp, “Detecting DNA cytosine methylation using nanopore sequencing,” Nature Methods, vol. 14, no. 4, pp. 407–410, Apr. 2017

R. E. Workman*, A. D. Tang*, P. S. Tang*, M. Jain*, J. R. Tyson*, R. Razaghi*, P. C. Zuzarte, T. Gilpatrick, A. Payne, J. Quick, N. Sadowski, N. Holmes, J. G. de Jesus, K. L. Jones, C. M. Soulette, T. P. Snutch, N. Loman, B. Paten, M. Loose, J. T. Simpson, H. E. Olsen, A. N. Brooks, M. Akeson§, and W. Timp, “Nanopore native RNA sequencing of a human poly(A) transcriptome,” Nature Methods, pp. 1–9, Nov. 2019

T. Gilpatrick, I. Lee, J. E. Graham, E. Raimondeau, R. Bowen, A. Heron, B. Downs, S. Sukumar, F. J. Sedlazeck, and W. Timp, “Targeted nanopore sequencing with Cas9-guided adapter ligation,” Nature Biotechnology, Feb. 2020

I. Lee, R. Razaghi, T. Gilpatrick, M. Molnar, A. Gershman, N. Sadowski, F. J. Sedlazeck, K. D. Hansen, J. T. Simpson, and W. Timp, “Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing,” Nature Methods, vol. 17, no. 12, pp. 1191–1199, Dec. 2020

P. M. Thielen*, S. Wohl*, T. Mehoke, S. Ramakrishnan, M. Kirsche, O. Falade-Nwulia, N. S. Trovão, A. Ernlund, C. Howser, N. Sadowski, C. P. Morris, M. Hopkins, M. Schwartz, Y. Fan, V. Gniazdowski, J. Lessler, L. Sauer, M. C. Schatz, J. D. Evans, S. C. Ray, W. Timp, and H. H. Mostafa, “Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore–Washington metropolitan area,” JCI Insight, vol. 6, no. 6, Mar. 2021.

Contact for Research Inquiries

Phone: 410-417-8467
Is this you? Edit Profile
back to top button