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Thomas William Sedlak, M.D., Ph.D.

Headshot of Thomas William Sedlak
  • Director, Schizophrenia and Psychosis Consult Clinic
  • Assistant Professor of Psychiatry and Behavioral Sciences


Adult Psychiatry, Neuropsychiatry, Psychiatry, Psychiatry and Behavioral Sciences, Schizophrenia more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-0424
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-614-6248

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-614-6248
4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-614-6248



  • Director, Schizophrenia and Psychosis Consult Clinic
  • Assistant Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Centers & Institutes



  • MD PhD; Washington University School of Medicine in St Louis (1999)


  • Psychiatry; Johns Hopkins University School of Medicine (2003)


  • Psychiatry; Johns Hopkins University School of Medicine (2006)

Board Certifications

  • American Board of Psychiatry and Neurology (Psychiatry-General) (2008)

Research & Publications

Research Summary

Our laboratory studies brain metabolic and antioxidant pathways relevant to normal brain biology and neuropsychiatric conditions such as schizophrenia and Alzheimer’s disease.


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Lab Website: Thomas Sedlak Lab

Selected Publications

View all on PubMed

Koga, M., Serritella, A.V., Sawa, A., and Sedlak, T.W. (2016). Implications for reactive oxygen species in schizophrenia pathogenesis. Schizophr Res 176, 52-71

Saito, A., Taniguchi, Y., Rannals, M.D., Merfeld, E.B., Ballinger, M.D., Koga, M., Ohtani, Y., Gurley, D.A., Sedlak, T.W., Cross, A., et al. (2016). Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Mol Psychiatry 21, 1449-1459

Sawa, A., and Sedlak, T.W. (2016). Oxidative stress and inflammation in schizophrenia.  Schizophr Res 176, 1-2

Sedlak, T.W., and Kaplin, A.I. (2016). Novel Neurotransmitters 2016. In Kaplan & Sadock's Comprehensive Textbook of Psychiatry, B.J. Sadock, V.A. Sadock, P. Ruiz, and H.I. Kaplan, eds. (Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins)

Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T.W., Korth, C., Brandon, N.J., et al. (2015). DISC1 regulates trafficking and processing of APP and Abeta generation  Mol Psychiatry 20, 874-879

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