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Sujatha Kannan, M.B.B.S.

Sujatha Kannan, M.B.B.S.

Headshot of Sujatha Kannan
  • Richard J. Traystman Endowed Chair
  • Professor of Anesthesiology and Critical Care Medicine
Female

Languages: English, Tamil

Expertise

Critical Care, Critical Care Medicine, Pediatric Critical Care Medicine, Pediatrics ...read more

Research Interests

Autism; Cerebral Palsy; Nanotechnology; Imaging and targeted therapy for perinatal brain injury ...read more

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Main Phone

Outside of Maryland & Washington D.C.

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Locations

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-6412
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Suite 6318D
Baltimore, MD 21287 map
Phone: 410-955-7610

Background

Dr. Sujatha Kannan is professor of anesthesiology and critical care medicine and pediatrics at the Johns Hopkins University School of Medicine. She is also the Richard J. Traystman Endowed Chair and the Vice Chair for Research for ACCM. She specializes in pediatric critical care with expertise in pediatric neurocritical care. In addition to her role at Johns Hopkins, Dr. Kannan is also a research scientist at the Hugo Moser Researcher Institute at Kennedy Krieger Institute.

Dr. Kannan completed her medical training at the Jawaharlal Institute of Post Graduate Medical Education and Research in Pondicherry, India. She conducted residencies in pediatrics at the University Illinois at Chicago and the Children’s Hospital of Michigan. Additionally, she completed a fellowship in pediatric critical care medicine at the Children’s Hospital of Michigan. Dr. Kannan joined the Johns Hopkins faculty in 2011.

Her research focuses on understanding the role of inflammation and immune dysregulation in the  brain with a goal to develop therapies for childhood brain injury and neurodevelopmental disorders such as cerebral palsy, Rett syndrome, autism, TBI and CNS infections. In collaboration with the Kannan Rangaramanujam lab at the Center for Nanomedicine, Wilmer Eye Institute, the S. Kannan lab has created and developed novel nanotherapies to specifically target immune cells in the brain to promote repair and regeneration. 

Dr. Kannan is a member of the Society for Neuroscience, the Society of Critical Care Medicine, and the Society for Pediatric Research. She is a fellow of the American Institute for Medical and Biological Engineering. She has published extensively and has won several awards for her research. She is board certified in pediatrics and pediatric critical care.

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Titles

  • Richard J. Traystman Endowed Chair
  • Vice Chair for Research, Anesthesiology and Critical Care Medicine
  • Professor of Anesthesiology and Critical Care Medicine
  • Professor of Pediatrics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MBBS; Jawaharlal Institute Of Postgraduate (1995)

Residencies

  • Pediatrics; Children's Hospital of Michigan (2000)
  • Pediatrics; University of Illinois at Chicago College of Medicine (1998)

Fellowships

  • Pediatric Critical Care Medicine; Children's Hospital of Michigan (2003)

Board Certifications

  • American Board of Pediatrics (Pediatric Critical Care Medicine) (2004)
  • American Board of Pediatrics (Pediatrics) (2000)

Research & Publications

Research Summary

Dr. Kannan's research focuses on understanding the mechanism and progression of the cellular and metabolic derangements leading to brain injury during development, and to use this information to design specific targeted therapy using nanotechnology. She and her team use a unique combination of animal model development, nanotechnology, and in vivo imaging to create these therapeutic strategies, with a special emphasis on cerebral palsy and autism.

Selected Publications

Kannan S, Dai H, Navath RS, Balakrishnan B, Jyoti A, Janisse J, Romero R, Kannan RM. Dendrimer-based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model. Science Translational Medicine. 2012 Apr 18;4(130):130ra46.

Navath RS, Menjoge AR, Dai H, Romero R, Kannan S, Kannan RM. “Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation.” Mol Pharm. 2011 Aug 1;8(4):1209-23.

Kannan S, Saadani-Makki F, Balakrishnan B, Chakraborty P, Janisse J, Xin Lu, Muzik O, Romero R, Chugani DC. “Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure.” Dev Neurosci. 2011;33(3-4):231-40. doi: 10.1159/000328125. Epub 2011 Jul 28.

Kannan S, Saadani-Makki F, Balakrishnan B, Dai H, Chakraborty P, Janisse J, Muzik O, Romero. R, Chugani D. “Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero.” J Cereb Blood Flow Metab. 2011 Feb;31(2):738-49. Epub 2010 Sep 8.

Dai H, Navath RS, Balakrishnan B, Raja Guru B, Mishra M, Romero R, Kannan RM, Kannan S. “Intrinsic targeting of neuroinflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration,” Nanomedicine (Lond). 2010 Nov;5(9):1317-29.

Wang B, Navath RS, Menjoge AR, Balakrishnan B, Bellair R, Dai H, Romero R, Kannan S, Kannan RM, “Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers.” Int J Pharm. 2010 Aug 16;395(1-2):298-308.

Patents

Dendrimer based nanodevices for therapeutic and imaging purposes
Patent # 10561673 | 

Dendrimer Compositions And Use In Treatment Of Neurological And CNS Disorders
Patent # 20170232120 | 

Compositions And Methods For Treatment Of Peroxisomal Disorders And Leukodystrophies
Patent # 20220071923 | 

Dendrimer Compositions And Methods For Treatment Of Severe Acute Respiratory Distress Syndrome
Patent # 20210353762 | 

Dendrimer Compositions And Use In Treatment Of Necrotizing Enterocolitis And Other Gastrointestinal Disorders
Patent # 20220080056 | 

Dendrimers For Sustained Release Of Compounds
Patent # 20200390694 | 

Activities & Honors

Honors

  • Teaching Award, Wayne State University School of Medicine, 2007
  • Scholar’s Award in Pain Medicine, Pfizer, 2004
  • Wolfe Zuelzer Award for Best Fellowship Research Project, Children's Hospital of Michigan, 2002
  • Sheldon Brenner Award for Best Resident Research Project, Children's Hospital of Michigan, 2000
  • 2020 Award of Excellence in Mentoring, Johns Hopkins SOM Scholarly Concentrations Program
  • Fellow, American Institute for Medical and Biological Engineering

Memberships

  • American Academy of Pediatrics, Critical Care Section
  • International Society for Cerebral Blood Flow and Metabolism
  • Society for Neuroscience
  • Society for Pediatric Research
  • Society of Critical Care Medicine

Videos & Media

Recent News Articles and Media Coverage

When Research Hits Home, Johns Hopkins University (August 24, 2021)

Hopkins married researchers develop COVID drug during personal tragedy, WMAR, October 14, 2021

Johns Hopkins Professor Leads by Example for Female Entrepreneurs, Johns Hopkins Technology Ventures, (February 7, 2020)

Dr. Sujatha Kannan Inducted into Medical and Biological Engineering Elite, AIMBE (March 28, 2019)

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