Sean Xiao Leng, M.D., Ph.D.

Headshot of Sean Xiao Leng
  • Professor of Medicine

Languages: English, Chinese


Geriatric Medicine

Research Interests

International collaborative development of geriatrics and aging research programs; Molecular virology: assessment of chronic cytomegalovirus infection and its contribution to chronic inflammation and immunosenescence in older adults; Immune response to and protection from influenza immunization in frail elderly; Cytokinology: IL-6 and other cytokine dysregulations in frail older adults; Chronic inflammation, immune activation, and their role in the pathogenesis of frailty; Aging of the innate and adaptive immune system more

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-0925
5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-2494 | Fax: 410-550-3143


Dr. Sean X. Leng is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include geriatric medicine.

Dr. Leng earned his M.D. from Jiangxi Medical College and his Ph.D. from Texas A&M University Health Sciences Center. He completed his residency at Mount Sinai St. Luke's - Roosevelt Hospitals and performed a fellowship in geriatric medicine and gerontology at Johns Hopkins.

His research interests include international collaborative development of geriatrics and aging research programs.

In 2006 Dr. Leng received the Paul Beeson Career Development Award in Aging Research, one of the most prestigious in the field of geriatric research. more


  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Jiangxi Medical College (1984)


  • Medicine; Mount Sinai St Lukes (2000)


  • Geriatric Medicine and Gerontology; Johns Hopkins Bayview Medical Center (2002)
  • Yale-New Haven Hospital (1997)

Board Certifications

  • American Board of Internal Medicine (Geriatric Medicine) (2002)

Additional Training

  • Texas A&M University / Ph.D. (1995)

Research & Publications

Research Summary

Dr. Leng's research has focused on the following three areas:

  1. Key components of senescent immune dysregulation in frail older adults, such as chronic inflammation and immune activation, and their adverse health consequences
  2. Factors and mechanisms that contribute to immune functional decline in older adults, such as chronic CMV infection
  3. Strategies to strengthen the aging immune system, such as influenza immunization in frail older adults, and promote healthy aging.

Selected Publications

View all on PubMed

Li HF, Mao GX, Carlson J, and Leng SX. A novel flow cytometry-based tool for determining the efficiency of human cytomegalovirus infection in THP-1 derived macrophages. J. Virological Methods 2015; 221:127-30.

Piggott DA, Varadhan R, Mehta SH, Brown TT, Li H, Walston JD, Leng SX, Kirk GD. Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci. 2015 Dec; 70(12):1542-7.

Leng SX, Dandorf S, LI HF, Carlson, J, Hui J, Mehta SH, Piggott DA, Islam S, Manwani B, and Kirk GD. Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at high risk for HIV infection. AIDS Res. Human Retroviruses 2015 Dec; 31(12):1257-64.

Ning XX, Ouyang M, and Leng SX. The geriatric syndrome of frailty: role of inflammation and immune activation. Chin. J. Geri. (in press)

Mao GX, Li HF, Wang GF, and Leng SX. Sirtinol suppresses human cytomegalovirus (hCMV) infection and hCMV-induced cellular senescence and production of reactive oxygen species in human fibroblasts. Mechanisms Ageing Development 2016 (in press)

Activities & Honors


  • Paul Beeson Career Development Award in Aging Research, 2006

Professional Activities

  • Faculty Development Program, Johns Hopkins University, 2002 - 2003
  • Faculty leadership training, Johns Hopkins University School of Medicine, 2006 - 2007
  • Special Volunteer, National Institute on Aging, 2001 - 2002

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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