Sarah R. Amend, Ph.D.

Headshot of Sarah R. Amend
  • Associate Professor of Urology



  • Associate Professor of Urology
  • Associate Professor of Oncology

Departments / Divisions



  • B.S.; North Carolina State University (North Carolina) (2008)
  • Ph.D.; Washington University in St. Louis (Missouri) (2014)

Research & Publications

Selected Publications

View all on PubMed

Leduc MS, Lyons M, Darvishi K, Walsh K, Sheehan S, Amend S, Cox A, Orho-Melander M, Kathiresan S, Paigen B, Korstanje R. The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol. J Lipid Res. 2011 Jun;52(6):1139-49.

Amend SR, Uluckan O, Hurchla M, Leib D, Novack DV, Silva M, Frazier W, Weilbaecher KN. Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts. J Bone Miner Res. 2015 Jan;30(1):106-15.

Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH. Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types. PLoS One. 2015 May 28;10(5):e0127828.

Xiang J, Hurchla MA, Fontana F, Su X, Amend SR, Esser AK, Douglas GJ, Mudalagiriyappa C, Luker KE,Pluard T, Ademuyiwa FO, Romagnoli B, Tuffin G, Chevalier E, Luker GD, Bauer M, Zimmermann J, Aft RL,Dembowsky K, Weilbaecher KN. CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer. Mol Cancer Ther. 2015 Nov;14(11):2473- 85.

Su X, Esser AK, Amend SR, Xiang J, Xu Y, Ross MH, Fox GC, Kobayashi T, Steri V, Roomp K, Fontana F,Hurchla MA, Knolhoff BL, Meyer MA, Morgan EA, Tomasson JC, Novack JS, Zou W, Faccio R, Novack DV, Robinson SD, Teitelbaum SL, DeNardo DG, Schneider JG, Weilbaecher KN. Antagonizing Integrin β3 Increases Immunosuppression in Cancer. Cancer Res. 2016 Jun 15;76(12):3484-95.

Parsana P, Amend SR, Hernandez J, Pienta KJ, Battle A. Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. BMC Cancer. 2017 Jun 26;17(1):447.

Axelrod HD, Valkenburg KS, Amend SR, Hicks J, Parsana P, Torga G, De Marzo A, and Pienta KJ. AXL is a putative tumor suppressor and dormancy regulator in prostate cancer. Molecular Cancer Research. 2019 Feb;17(2):356-369.

Dong L, Zhang Z, Smith K, Kuczler M, Reyes D, Amend SR, Cho YK, Xue W, Pienta KJ. The combination of size-based separation and selection-free technology provides higher circulating tumor cells detection sensitivity than either method alone in patients with metastatic prostate cancer. BJU International. 2020.

Lin KC, Sun Y, Torga G, Sherpa P, Zhao Y, Qu J, Amend SR, Pienta KJ, Sturm JC, Austin RH. An in vitro tumor swamp model of heterogeneous cellular and chemotherapeutic landscapes. Lab on a Chip. In press.

Zieren RC, Dong L, Amend SR, Pienta KJ. Chapter V: Clinical Aspects of Cancer: Classification of Tumors, Their Frequency and Prognosis. Cancer: Prevention, Early Detection, Treatment and Recovery, 167-211. ed. Gary Stein; Wiley Publishers. 2019.

Contact for Research Inquiries

600 N. Wolfe Street
Marburg Building, Room 105A
Baltimore, MD 21287-2101 map

Activities & Honors


  • University Honors Program, North Carolina State University, 2004-2008, North Carolina State University
  • College of Agriculture and Life Sciences Honors Program, North Carolina State University, 2004-2008
  • Caldwell Fellow, North Carolina State University, 2005-2008
  • Founder’s Award, University Honors Village, North Carolina State University, 2005
  • summa cum laude, North Carolina State University, 2008
  • Center for Creative Leadership University Leadership Program certificate, 2008
  • The Horace W. Goldsmith Foundation award at The Jackson Laboratory, 2008
  • James P. Murphy Memorial Scholarship at The Jackson Laboratory, 2008
  • Lucille P. Markey Pathway in Human Pathobiology at Washington University School of Medicine, 2010-2012
  • Young Investigator Award, European Calcified Tissue Society /American Society for Bone and Mineral Research, 2012
  • Young Investigator Travel Award, International Bone & Mineral Society / Cancer Induced Bone Disease, 2012
  • American Association for Cancer Research Translational Cancer Research for Basic Scientists Workshop, 2015
  • Aflac Scholar-in-Training award, American Association for Cancer Research, 2015
  • Fellow, Aspen Cancer Conference, Aspen, CO, 2018
  • Junior Faculty Leadership Program, Johns Hopkins University School of Medicine, Baltimore, MD, 2020


  • Caldwell Fellows, North Carolina State University (reviewer and finalist selection), 2008
  • Cancer and Bone Society, member, 2010
  • American Society of Bone and Mineral Research, member, 2010 - 2014
  • American Association for Cancer Research, member, 2014
  • AACR-Women in Cancer Research, member, 2014
  • Tumor microenvironment working group, member, 2014
  • International Society for Evolution, Ecology and Cancer, member, 2019
  • American Urological Association, member, 2019
  • Society for Basic Urologic Research, member, 2019
  • Metastasis Research Society, member, 2020
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