- Assistant Professor of Medicine
Our group is working to expand the understanding of how hormones regulate pancreatic islets in health and disease.
A major focus of the lab is to define the normal physiologic adaptations of islets, particularly insulin-producing beta-cells, to the metabolic stress of pregnancy. We hope to use this knowledge to determine how defective adaptation contributes to gestational diabetes (GDM).
We anticipate that uncovering mechanisms of gestational beta-cell adaptation will help identify novel therapeutic strategies to expand functional beta-cell mass and lead to new treatments for all types of diabetes.
Lab Website: Banerjee Lab
Banerjee RR, Spence T, Frank SJ, Pandian R, Hoofnagle AN, Argiropoulos, Marcadier JL. Very Low Vitamin D in a Patient with a Novel Pathogenic Variant in the GC Gene that encodes Vitamin D-Binding Protein. Journal of the Endocrine Society. ePub 05 June 2021. https://doi.org/10.1210/jendso/bvab104
Moon JH, Kim H, Kim H, Park J, Choi W, Hong HJ, Ro H-J, Jun S, Choi SH, Banerjee RR, Shong M, Cho, NH, Kim SK, German MS, Jang HC, Kim H. Lactation improves pancreatic β cell mass and function through serotonin production. Science Translational Medicine. 2020 Apr 29; vol 12 (541). PMID: 32350130
Pepin ME, Bickerton HH, Bethea M, Hunter CS, Wende AR, Banerjee, RR. Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islet. Endocrinology. 2019 May 1;160(5):1150-1163. doi: 10.1210/en.2018-00991. PMID: 31004482
Banerjee RR, Cyphert HA, Chakravarti H, Gu X, Liu Y, Conrad L, Goodrich L, Stein R, Kim SK Gestational diabetes from inactivation of prolactin receptor and MafB in islet b-cells. Diabetes. 2016 Aug; 65(8):2331-41. doi: 10.2337/db15-1527. Epub 2016 May 23. PMID: 27217483. PMCID: PMC4955982
Banerjee RR*, Rangwala SM*, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA. Regulation of fasted blood glucose by resistin. Science. 303: 1195-1198. 20 February 2004. PMID 14976316.(*co-first author)
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