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Rachel Green, Ph.D.

Headshot of Rachel Green
  • Bloomberg Distinguished Professor of Molecular Biology and Genetics
  • Professor of Molecular Biology and Genetics

Research Interests

Molecular Mechanisms of Protein Synthesis; Ribosome-Mediated Quality Control; and Translational Control in Health and Disease ...read more

Background

Dr. Rachel Green is a Bloomberg Distinguished Professor of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine.

Dr. Green’s work has been supported by the  Howard Hughes Medical Institute since 2000. Her laboratory focuses on examining the molecular mechanisms of translation and their implications for gene regulation in bacteria, yeast and higher eukaryotic systems. Recent work has focused on mechanistic aspects of ribosome-mediated quality control and with the intersection between ribosome function and cellular fate signaling pathways. These studies have direct relevance to cellular homeostasis in health and disease.

Dr. Green joined the Johns Hopkins faculty as an assistant professor in 1998. She earned her Ph.D. in biological chemistry at Harvard University before completing a postdoctoral fellowship at the University of California, Santa Cruz. She also holds a B.S. with honors in chemistry from the University of Michigan.

Dr. Green has published scores of journal articles and garnered a number of awards and honors, including being named the Johns Hopkins School of Medicine’s Teacher of the Year in 2005.

She serves on the SAB at Moderna and consults for numerous other biotech industries.

Dr. Green was elected to the National Academy of Sciences in 2012. 

...read more

Titles

  • Bloomberg Distinguished Professor of Molecular Biology and Genetics
  • HHMI Investigator
  • Professor of Molecular Biology and Genetics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; Harvard University (Massachusetts) (1992)

Additional Training

  • University of California, Santa Cruz, Santa Cruz, CA, 1998, Biology

Research & Publications

Lab

The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. Our work focuses on understanding how the ribosome functions at a molecular level and how changes in its activity lead to mRNA quality control and the induction of cellular stress responses. Work in the Green lab ranges widely in scope, from detailed mechanistic questions in ribosome rescue to surveying global changes in gene expression and dissecting the complex interplay of mammalian signaling pathways. We use a wide range of genetic, genomic, and biochemical approaches to explore these questions in bacteria, yeast, and increasingly in mammalian systems. Much of our ongoing work focuses on the importance of ribosome collisions in activating signaling pathways such as the integrated stress response (ISR) and various MAP kinase cascades.

Lab Website: Green Lab

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry, Cellular and Molecular Biology Graduate Program

Program in Molecular Biophysics

Activities & Honors

Honors

  • Postdoctoral Fellowship, American Cancer Society (California Division), 1996
  • Investigator, Howard Hughes Medical Institute, 2000
  • Assistant Investigator Award, Howard Hughes Medical Institute, 2000
  • Teacher of the Year, Johns Hopkins University School of Medicine, 2005
  • Predoctoral Fellowship, National Science Foundation, 1987
  • David and Lucile Packard Fellowship Award, 2000
  • Searle Scholarship Award, 1999
  • Award for Young Scientists, RPI/RNA , 1999
  • Burroughs Wellcome Career Award, 1996
  • Damon Runyon Walter Winchell Postdoctoral Fellowship, 1993
  • Member, National Academy of Medicine, 2017
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