Our research focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Our lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. We use mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and cognitive developmental defects, infertility, and cancer predisposition. We also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. Our current research encompasses the following:
- Gametogenesis (spermatogenesis and oogenesis)
- Pluripotent stem cell genome maintenance
Lab Website: Jordan Lab
Technology Expertise Keywords
Meiosis; Structural maintenance of chromosomes; SMC5; SMC6;Polo-like kinase; PLK; Aurora kinase; AURK; Chromosome segregation; recombination; DNA repair; cell cycle; gametogenesis; embryonic stem cells; neural stem cells; neurodevelopment
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Alisa Atkins, Michelle J. Xu, Maggie Li, Nathaniel P. Rogers, Marina V. Pryzhkova, Philip W. Jordan (2020) SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. eLife. e61171
Wellard S, Schindler K and Jordan PW (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male mice and humans. J. Cell Sci. 133: jcs248831
Pryzhkova MP, Xu M and Jordan PW. (2020) Adaptation of the AID system for stem cell and transgenic mouse research. Stem Cell Research. (49): 102078.
Hwang G, O’Brien M, Sun F, Eppig J, Handel MA, Jordan PW (2017) SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 144: 1648-1660
Hopkins J, Hwang G, Jacob J, Sapp N, Bedigian R, Oka K, Overbeek P, Murray S and Jordan P. (2014) Meiosis-specific cohesin component, Stag3 is essential for mediating recombination and synapsis between homologous chromosomes and maintaining sister chromatid cohesion. PLoS Genetics; 10 (7) e1004413