Angioplasty, Cardiac Catheterization, Cardiology, Cardiovascular Disease, Cardiovascular Medicine, Coronary Artery Disease, Coronary Artery Stenting, Fractional Flow Reserve, Heart Attack, Heart Disease, Interventional Cardiology, Intravascular Ultrasound (IVUS), Myocardial Infarction, Stenting ...read more
Stem Cell Therapy for the Heart; Optimization of primary angioplasty for acute myocardial infarction ...read more
Dr. Johnston joined the Cardiology Faculty in 2008 and currently practices Interventional Cardiology at Johns Hopkins Hospital, Bayview Medical Center, and Johns Hopkins Howard County Medical Center. His primary research interest is in novel therapies for heart failure and he is involved in both clinical trials and pre-clinical studies currently underway at Johns Hopkins.
Cell therapy; Gene therapy; Interventional Cardiology
Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Steenbergen C, Gerstenblith G, Lange R, Marbán E. Engraftment, differentiation and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation. 2009;120(12):1075-83
Makkar R, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet. 2012;379(9819):895-904
Johnston PV, Duckers HJ, Raval AN, Cook TD, Pepine CJ. Not all stem cells are created equal: the case for prospective assessment of stem cell potency in the CardiAMP heart failure trial. Circ Res 2018;123:944-6
Johnston PV, Hwang CW, Bogdan V, Mills KJ, Eggan ER, Leszczynska A, Wu KC, Herzka DA, Brinker JA, Schulman SP, Banerjee M, Florea V, Natsumeda M, Tompkins B, Balkan W, Hare JM, Tomaselli GF, Weiss RG, Gerstenblith G. Intravascular stem cell bioreactor for prevention of adverse remodeling after myocardial infarction. J Am Heart Assoc, 2019;8:e012351
Hung G, Ashvetiya T, Leszczynska A, Yang W, Hwang CW, Gerstenblith G, Barth AS, Johnston PV. Paracrine-mediated rejuvenation of aged mesenchymal stem cells is associated with downregulation of the autophagy-lysosomal pathway. NPJ Aging 2022 Jul 18; 8(10)
Cell impregnated sleeve for paracrine and other factor production
Patent # U.S. Patent #10,561,830 | 02/18/2020
A Device and Method for Non-Invasive Left Ventricular End Diastolic Pressure (LVEDP) Measurement.
Patent # U.S. Patent #10,729,337 | 08/04/2020
Methods for Promoting Healing of Tissue
Patent # U.S. Patent #10,772,716 | 09/15/2020
Cell impregnated sleeve for paracrine and other factor production
Patent # Patent #10,987,501 | 04/27/2021
FACC
FAHA
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