Dr. Parrish’s research is related to tuberculosis, with a particular interest in emerging multi-drug resistant and extensively drug resistant tuberculosis strains. Her research focuses on uncovering novel compounds with potent antimycobacterial activity and developing rapid diagnostics for the detection of drug resistance. She and her team use a variety of methods, including proteomics, protein and lipid biochemistry as well as current molecular techniques.
Parrish, N.M., F.P. Kuhajda, H.S. Heine, W.R. Bishai, and J.D. Dick. 1999. Antimycobacterial activity of cerulenin and its effects on lipid biosynthesis. Journal of Antimicrobial Chemotherapy. 43: 219-226.
Jones, P.B., N.M. Parrish, T.A. Houston, A. Stapon, N.P. Bansal, J.D. Dick, and C.A.Townsend. 2000. A new class of antituberculosis agents. J. Med. Chem. 43(17): 3304-14.
Parrish, N.M, C. Townsend, P. Jones, T. Houston, and J. Dick. 2001. In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrob. Agents Chemother. 45:1143-1150.
Parrish, N.M., C.A. Townsend, C.G. Ko, and J.D. Dick. 2004. Effect of n-Octanesulfonylacetamide (OSA) on ATP and protein expression in Mycobacterium bovis BCG. J. Antimicrob. Chemother. 54(4): 722-9.
Parrish, N.M., C.A. Townsend, C.G. Ko, and J.D. Dick. 2004. Congo red agar colony morphotypes and antibiotic susceptibility testing of M. avium subspecies paratuberculosis. 2004. Clinical Medicine and Research. 2: 107-114.
Hendry C, Dionne K, Hedgepeth A, Carroll K, and Parrish N. “Evaluation of a Rapid, Fluorescent Stain for the Detection of Mycobacteria in Clinical Specimens”. J. Clin. Microbiol. April 2009; 47(4): 1206-1208.
Parrish N, Dionne K, Sweeney A, Hedgepeth A, and Carroll K. “Differences in Time to Detection and Recovery of Mycobacterium species between the MGIT 960 and the BacT/ALERT MB Automated Culture Systems.” Diagn. Microbiol. Infect. Dis. 2009; 63(3): 342-345.
Parrish NM, Radcliff RP, Brey BJ, Anderson JL, Clark DL Jr, Koziczkowski JJ, Ko CG, Goldberg ND, Brinker DA, Carlson RA, Dick JD, Ellingson JL. “Absence of Mycobacterium avium subsp. paratuberculosis in Crohn's patients.” Inflamm Bowel Dis. 2009 Apr;15(4):558-65.
Parrish N and Carroll K. “Importance of improved TB diagnostics in addressing the extensively drug-resistant TB crisis.” Future Microbiol. 2008 Aug;3: 405-413.
Parrish N, Osterhout G, Dionne K, Sweeney A, Kwiatkowski N, Carroll K, Jost KC, Jr, and Dick J. “A Rapid, Standardized, Susceptibility Method for Mycobacterium tuberculosis using Mycolic Acid Analysis.” J Clin. Micro. Dec 2007; 45: 3915-3920
Parrish, N.M., J. D. Dick and W.R. Bishai. 1998. Mechanisms of latency in Mycobacterium tuberculosis. Trends in Microbiology. 6: 107-112.