Skip Navigation

Nicholas John Maragakis, M.D.

Headshot of Nicholas John Maragakis
4.9out of 5
56 Ratings
  • Director, ALS Center for Cell Therapy and Regeneration Research
  • Professor of Neurology
Male

Expertise

Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's Disease, Neurology ...read more

Request an Appointment

Insurance Information

Main Phone

410-614-9874

Outside of Maryland

410-464-6641
Request Appointment

International Patients

+1-410-502-7683
Request Appointment

Locations

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-614-9874
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-614-9874
601 N. Caroline St.
Baltimore, MD 21287 map

Background

Dr. Maragakis treats patients with a variety of neuromuscular disorders. His clinical practice is particularly notable for its attention to patients with motor neuron diseases, such as Amyotrophic Lateral Sclerosis (ALS). This expertise is coordinated with the ALS clinic at Johns Hopkins, a multidisciplinary clinic with expertise in treating ALS patients and providing support to their caregivers. As an extension of Dr. Maragakis clinic, he is an investigator in clinical trials for ALS patients.

Dr. Maragakis has interests in both the basic science of understanding neurologic disease as well as clinical investigations for treating neurologic disorders. His laboratory studies the role of astrocytes (the supporting cells of the brain) in causing and propagating neurological diseases, such as ALS. His interests also include the use and transplantation of astrocyte stem cells into animal models of diseases to establish their potential to treat patients with neurologic disease. His clinical research interests have included the treatment of patients with ALS using new drug therapies. Studies are also planned to evaluate potentially new approaches in ALS therapy.

...read more

Titles

  • Director, ALS Center for Cell Therapy and Regeneration Research
  • Medical Director, ALS Clinical Trials Unit
  • Director, Center for ALS Specialtiy Care
  • Professor of Neurology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; The University of Utah (1994)

Residencies

  • Neurology; Johns Hopkins University School of Medicine (1998)

Fellowships

  • Clinical Neurophysiology; Johns Hopkins University School of Medicine (1999)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2000)

Research & Publications

Lab

The Maragakis lab's main focus is in understanding disease mechanisms and targeting cell therapeutics for Amyotrophic Lateral Sclerosis (ALS). In collaboration with Johns Hopkins neuroscientists, his laboratory helped create stem cell lines from ALS patients using induced pluripotent stem cell (iPSC) methodologies. These cells will allow for the development of human cell lines which can be used for both the basic understanding of ALS astrocyte and motor neuron biology, as well as eventually identifying ALS therapeutics. Researchers in the Maragakis lab also focus on the potential therapeutic role of astrocyte replacement in ALS using glial stem cells. By transplanting glial stem cells into ALS animal models, the researchers in the Maragakis lab found that the stem cells can engraft, migrate and differentiate into astrocytes, and subsequently provide neuroprotection to vulnerable motor neuron pools. The team uses stem cell transplantation biology to understand the influences of mutant SOD1 astrocytes on normal, healthy motor neurons. A significant laboratory effort is underway to translate these discoveries into therapies for patients with ALS.

Lab Website: ALS Center

Selected Publications

View all on PubMed

Taga A, Dastgheyb R, Habela C, Joseph J, Richard J-P, Gross SK, Lauria G, Lee G, Haughey N, Maragakis NJ.  Role of human induced pluripotent stem cell-derived spinal cord astrocytes in the functional maturation of motor neurons in a multielectrode array system.  Stem Cells Transl Med. 2019 Dec;8(12):1272-1285. doi: 10.1002/sctm.19-0147. Epub 2019 Oct 21 PMID:31631575 PMCID:PMC6877769

Almad AA, Doreswamy A, Gross SK, Richard JP, Huo Y, Haughey N, Maragakis NJ.  Glia. 2016 Apr 16. doi: 10.1002/glia.22989. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis.

Haidet-Phillips AM, Doreswamy A, Gross SK, Tang X, Campanelli JT, Maragakis NJ. Human glial progenitor engraftment and gene expression is independent of the ALS environment. Exp Neurol. 2015 Feb;264:188-99. PubMed PMID: 25523812. 

Haidet-Phillips AM, Roybon L, Gross SK, Tuteja A, Donnelly CJ, Richard JP, Ko M, Sherman A, Eggan K, Henderson CE, Maragakis NJ. Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem Cells Transl Med. 2014 May;3(5):575-85. PubMed PMID: 24604284; PubMed Central PMCID: PMC4006486. 

5.Haidet-Phillips AM, Gross SK, Williams T, Tuteja A, Sherman A, Ko M, Jeong YH, Wong PC, Maragakis NJ. Altered astrocytic expression of TDP-43 does not influence motor neuron survival. Exp Neurol. 2013 Dec;250:250-9. PubMed PMID: 24120466.

Contact for Research Inquiries

Email me

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

  • 5.0 Provider Explained Things Clearly
  • 5.0 Provider Listened Carefully
  • 4.8 Provider Gave Easy to Understand Instructions
  • 4.9 Provider Knew Medical History
  • 5.0 Provider Showed Respect
  • 4.9 Provider Spent Enough Time
  • 4.9 Overall Rating by Patient

Comments

4.9 out of 5 (56 Ratings, 28 Comments)
    Is this you? Edit Profile
    back to top button