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Mohammad Obaidul Hoque, D.D.S., Ph.D.

Headshot of Mohammad Obaidul Hoque
  • Associate Professor of Oncology

Research Interests

Develop and validate genetic and epigenetic approach for early cancer diagnosis, cancer risk assessment and cancer prognosis; Molecular biologic basis of head and neck, lung and genitourinary cancer more


Dr. Hoque is an Associate Professor of Otolaryngology-Head & Neck Surgery, Urology and Oncology at Johns Hopkins University School of Medicine. Dr. Hoque completed dental and oral surgery training at the Dhaka Dental College, Dhaka University, Bangladesh. He then moved to Japan for the completion of Ph.D degree, where he also completed Advanced Clinical Training in Oral and Maxillofacial Surgery and Oncology. After training in Japan, he worked in the Head and Neck Cancer Research Division as a Postdoctoral Fellow under the mentorship of Dr. David Sidransky. He joined as a faculty member in 2006 in the Department of Otolaryngology-Head and Neck Surgery. His research interests includes: a) To understand molecular biologic basis of head and neck, lung and genitourinary cancer b) To develop and validate genetic and epigenetic approach for early cancer diagnosis, cancer risk assessment and cancer prognosis and c) To identify molecular alterations due to environmental exposures such as active smoking, passive smoking and arsenic. more


  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes



  • B.S.; Dhaka University (Bangladesh) (1988)
  • D.D.S.; Dhaka University (Bangladesh) (1995)
  • Ph.D.; University of Tokushima - Tokushima (Japan) (1998)

Research & Publications

Selected Publications

BraitM, MunariE, LeBron C, Noordhuis MG, Begum S, Michalidi C, Gonzalez-Roibon N,  Maldonado L,    Sen T,  Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D and Hoque MO. Genome-Wide Methylation Profiling and the PI3K-AKT Pathway Analysis Associated with Smoking in Urothelial Cell Carcinoma. Cell Cycle. 2013 Feb 22; 12 (7). PMID: 23435205

Zhong X, Isharwal S, Naples JM, Shiff C, Veltri RW, Shao C, Bosompem KM, Sidransky D and Hoque MO. Hypermethylation of genes detected in urine from Ghanaian adults with bladder     pathology associated with Schistosoma haematobium infection. PLoS One. 2013; 8 (3):e59089.PMID: 23527093

Ostrow KL, Michalidi C, Guerrero-Preston R, Hoque MO, Greenberg A, Rom W and Sidransky D. Cigarette smoke induces methylation of thetumor suppressor gene NISCH.   Epigenetics, 2013 Mar 15; 8 (4). PMID: 23503203

BraitM, Maldonado L, Noordhuis M, Begum S, Loyo M, Poeta ML,  BarbosaA, FazioVM, Angioli R, Rabitti C, Marchionni L, Graeff P,  Zee AGJ, Wisman GB,Sidransky D, Hoque MO. Association    of promoter methylation of VGF and PGP9.5 with ovarian cancer progression. PLoS One. 2013 Sep   27;8 (9):e70878. doi: 10.1371/journal.pone.0070878. PMID: 24086249

Enrico Munari, Luigi Marchionni, Apurva Chitre, Masamichi Hayashi, Guido Martignoni, Matteo Brunelli, Stefano Gobbo, Pedram Argani, Mohamad Allaf, Hoque MO, George J. Netto. Clear cell papillary renal cell carcinoma: microRNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell Carcinoma. Human Pathology 01/2014 Hum Pathol. 2014 Jun;45(6):1130-8. doi: 10.1016/j.humpath.2014.01.013. Epub 2014 Jan 31. (Corresponding author). PMID: 24703100

Maldonado L, Brait M, Loyo M, Sullenberger L, Wang K, Peskoe SB, Rosenbaum E, Howard R, Toubaji A, Albadine R, Netto GJ, Hoque MO, Platz EA, Sidransky D. GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer. J Urol. 2014 Apr 21. pii: S0022-5347(14)03413-2. doi: 10.1016/j.juro.2014.04.082. PMID: 24769028

Izumchenko EG, Chang X, Michailidi C, Kagohara LT, Ravi R, Paz K, Brait M, Hoque MO, Ling S, Bedi A, Sidransky D. The TGFβ-miR200-Mig6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. Cancer Res. 2014 May 15. PMID: 24830724

Hayashi M, Bernert H, Kagohara LT, Maldonado L, Brait M, Schoenberg M, Bivalacqua T, Netto GJ, Koch W, Sidransky D, Hoque MO. Epigenetic inactivation of VGF associated with Urothelial Cell Carcinoma and its potential as a non-invasive biomarker using urine. Oncotarget. 2014 May 7. PMID: 24830820

Maldonado L, Brait M, Michailidi C, Munari E, Driscoll T, Schultz L, Bivalacqua T, Schoenberg M, Sidransky D, Netto GJ and Hoque MO. An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine.  Oncotarget,   2014, Jun 23. PMID: 24980822

MunariM,  ChauxA, Maldonado L,  CompératE, BivalacquaTJ, Hoque MO, Netto GJ. Cyclin A1 Expression is Associated with Tumor Progression in pT1 Urothelial Carcinoma of Bladder: A Tissue Microarray Study of 149 Patients Treated by Transurethral Resection.  Histopathology, 2014 Jul 12. doi: 10.1111/his.12499. [Epub ahead of print] PMID: 25039670 (corresponding author).

Activities & Honors


  • Dhaka Board and Dhaka University Outstanding student Scholarship, 1983 - 1988
  • Monbusho (Ministry of Education) Scholarship, 1993 - 1998
  • Fuji Otsuka International fellowship, 1998 - 1999
  • JSPS (Japan Society for Promotion of Science) Fellowship, 1999 - 2000
  • AACR–Busch Travel Fund Scholar-in-Training Award at 94th Annual Meeting of American Association for Cancer Research, 2003
  • AACR-Astra Zenaca Scholar-in-Training Award at 95th Annual Meeting of American Association for Cancer Research, 2004
  • Young Clinical Scientist Award (FAMRI), 2006 - 2011
  • Young Investigator Award (IASLC), 2007 - 2009
  • Career Development Award (Cervical Spore), 2008 - 2010


  • American Association of Cancer Research (AACR), 1999
  • Bangladesh Dental Society, 1990
  • International Association for the Study of Lung Cancer (IASLC), 2007
  • Japanese Cancer Association, 1999 - 2000
  • Maryland Cancer Collaborative group (Subgroup: Early Detection and Treatment)., 2012

Videos & Media

Lectures and Presentations

  • High-throughput molecular analysis of urine sediment for the detection of bladder cancer by high-density single-nucleotide polymorphism array Venue: 94th Annual Meeting of American Associationfor Cancer Research
  • Detection of promoter hypermethylation of multiple genes in the tumor
    95th Annual Meeting of American Associationfor Cancer Research   (01/01/2003)
  • Genetic and Epigenetic Alterations in Bladder Cancer Progression and Diagnosis
  • Genetic and Epigenetic Alterations in Bladder Cancer: From Bench to Bedside. Department of  Urology
    The University of Texas M.D. Anderson Cancer Center (01/28/2005)
  • Integrated Genomic and Epigenomic Approach for Biomarker Development and Non-invasive Diagnosis of Cancer
  • Genetic and Epigenetic Alterations in Human Cancer: from Bench to Bedside
    Seattle (01/01/2005)
  • Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside
    Augusta (01/01/2006)
  • Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside
    Iowa City (01/18/2006)
  • Genetic and Epigenetic Alterations in Human Cancer
    JHUSOM (01/16/2006)
  • Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside
    New Orleans (01/16/2006)
  • Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside
  • Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside
    San Diego (01/21/2007)
  • The Cancer Epigenome and the Epigenetic Diagnostics of Cancer
    SKCC (01/27/2007)
  • Emerging Epigenetic Biomarkers for Cancer Diagnosis and Implication for Prevention and Treatment
  • Promoter Methylation of Prostate Cancer Specific Genes in low-income African American Adults
  • Harnessing Epigenetic Biomarkers: From Discovery to Clinical Implications
  • Molecular Alterations in Bladder Cancer: From the Laboratory to Clinical Applications
     University of New Mexico (01/31/2008)
  • Harnessing Molecular Biomarkers: From Bench to Bedside
    School of Medicine (01/18/2008)
  • Discovery and Implication of Genetic and Epigenetic Molecular Markers of Cancer
  • The Cancer Methylome: Epigenetic Biomarkers for Human Cancer
  • Epigenetic Silencing in Cancer: From Discovery to Clinical Implications
  • The Cancer Methylome: From Discovery to Clinical Implications
    Cancer Center and School of Public Health. (01/15/2008)
  • Molecular Alterations in Cancer and its Clinical Implications
    Viale Padre PIO 71013 , San Giovanni Rotondo (01/15/2008)
  • Methylation Markers for Early Detection of Prostate Cancer and Risk Prediction
    Lisbon (01/16/2008)
  • Action at a Distance: Epigenetic Silencing in Cancer
  • Cancer Methylome
    Anderson Cancer Institute, Mercer University (01/29/2009)
  • Genomic to the Epigenomic Era: Steps Towards Biomarker Discovery
    Barcelona (01/05/2009)
  • Human Biobank : Advancing the Vision of Personalized Medicine
     Bangabandhu Sheikh Mujib Medical University, Shahbagh (01/17/2009)
  • Genetic and Epigenetic Alterations in Cancer and its Clinical Implications
    Shahbagh (01/21/2009)
  • Genetic and Epigenetic  Alterations in Cancer and its Clinical Implications
    Bangladesh (01/22/2009)
  • Fundamentals of Cancer: Cause to Management
    Macon (01/22/2010)
  • Association Between Lifestyle Factors and CpG Island Methylation in a Cancer-free Population
    Cancer Prevention & Control Communication Network, Baltimore (01/25/2010)
    Johns Hopkins Bloomberg School of Public Health
  • Marching from the Genomic to the Epigenomic Era:Epigenetic Marks as Detectors
    Sultan Qaboos University, Oman (01/24/2011)
    College of Medicine & Health Sciences
  • Bladder Cancer Resulting from Exposure to Arsenic: Potential Screening Tool for Risk Assessment and Early Detection
    University of Arizona (01/22/2012)
  • Epigenetic Alterations related to Oral Diseases and Major Smoking Related Cancers: Scientific Evidence and Challenges Ahead. The 68th Japanese Stomatology Annual Meeting
    Tokyo (01/09/2014)
  • Molecular Heterogeneity and Personalized Cancer Medicine: Are We on The Right Track? Dokkyo Medical University School of Medicine
    Mibu-machi, Shimotsuga-gun, Tochigi (01/12/2014)
  • Environmental Influences on Tumor Heterogeneity and Personalized Management of Cancer Patients: Opportunities and Challenges. University of Oklahoma Health Sciences Center
    Oklahoma (01/11/2014)
  • Translational Cancer Research: Converting “OMICS” into Personalized Patient Management. Boston University School of Medicine
    Boston (01/31/2014)
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