Research Summary
My research interests focus on the development of novel MRI and MRS techniques to study cardiovascular disease in patients. These include the development of MRI methods to non-invasively quantify coronary endothelial function that previously could only be measured by invasive cardiac catheterization. Endothelial dysfunction is a marker for sub-clinical disease, an independent predictor of adverse cardiac events, and a potential target for medical interventions when disease progression is still reversible; and the development of MRI/MRS methods to non-invasively quantify energy metabolism in the human heart and exercising leg to better understand disease mechanisms in people suffering from heart failure, fatigue, and HIV.
Technology Expertise Keywords
Magnetic Resonance Imaging and Spectroscopy
Selected Publications
View all on PubMed
Schär M, Kozerke S, Fischer SE, Boesiger P. Cardiac SSFP Imaging at 3 Tesla. Magn Reson Med. 2004;51:799-806
Schär M, Vonken E-J, Stuber M; Simultaneous B0- and B1+-map Acquisition for Fast Localized Shim, Frequency and RF Power Determination in the Heart at 3T. Magn Reson Med. 2010;63(2):419-26
Schär M, El-Sharkawy AM, Weiss RG, Bottomley PA. Triple Repetition Time Saturation Transfer (TRiST) 31P Spectroscopy for Measuring Human Creatine Kinase Reaction Kinetics. Magn Reson Med. 2010;63(6):1493-1501
Bonanno G, Hays AG, Weiss RG, Schär M. Self-Gated Golden Angle Spiral Cine MRI for Coronary Endothelial Function Assessment. Magn Reson Med. 2018;80(2):560-70
Zhu D, Bonanno G, Hays AG, Weiss RG, Schär M; Phase contrast coronary blood velocity mapping with both high temporal and spatial resolution using triggered Golden Angle rotated Spiral k-t Sparse Parallel imaging (GASSP) with shifted binning. Magn Reson Med. 86:1929–43, 2021
