Research Summary
- Major research interests are in the area of cognitive change with age
- Disease-related changes of cognition (with a particular focus on Alzheimer's Disease)
- The relationship of cognitive change to brain structure and function, as assessed through imaging (e.g., MRI, fMRI, SPECT) and genetics
- Recent studies have focused on how to predict who will develop Alzheimer's disease over time
- Additional research efforts have included epidemiological studies of predictors of the maintenance of cognitive function, as well as cognitive decline
Clinical Trials
Alzheimer’s Disease Neuroimaging Initiative
Selected Publications
View all on PubMed
Soldan A, Pettigrew C, Li S, Wang MC, Moghekar A, Selnes OA, Albert M, O'Brien R, BIOCARD Research Team. Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease. Neurobiol Aging. 2013; 34: 2827-2834.
Bakker A, Kraus G, Albert M, Speck C, Jones L, Stark C, Yassa M, Bassett S, Shelton A, Gallagher M. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 2012; 74: 467-474.
Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 270-279.
Dickerson B, Stoub T, Shah R, Sperling R, Killiany R, Albert M, Hyman B, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurol 2011; 76: 1395-1402.
Yassa M, Stark C, Bakker A, Albert M, Gallagher M, Stark C. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment. Neuroimage 2010; 51: 1242-1252.
Blacker D, Lee H, Muzikansky A, Martin E, Tanzi R, McArdle J, Moss M, Albert M. Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol, 2007; 64: 862-871.
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