Research Summary
Dr. Penet has a strong background in imaging mice with MR techniques. Her imaging expertise began during her Ph.D. when she performed brain imaging studies of mice infected with Plasmodium berghei ANKA, parasites that induce the murine form of cerebral malaria. As a post-doctoral fellow in Pr. Zaver Bhujwalla’s laboratory, she worked on imaging orthotopic prostate cancer models. She has also performed surgical orthotopic implantation of prostate tumor pieces in male SCID mice.
Selected Publications
Penet MF, Abou-Hamdan M, Coltel N, Cornille E, Grau GE, de Reggi M, Gharib B. “Protection against cerebral malaria by the low molecular-weight thiol panthetine” PNAS 105:1321-1326 (2008) (PMCID: PMC2234136).
Penet MF, Pathak AP, Raman V, Ballesteros P, Artemov D, Bhujwalla ZM. “Noninvasive Multi-parametric Imaging of Metastasis-Permissive Microenvironments in a Human Prostate Cancer Xenograft” Cancer Res 69:8822-9 (2009) (PMCID: PMC2783669).
Penet MF, Gadiya MM, Krishnamachary B, Nimmagadda S, Pomper MG, Artemov D, Bhujwalla ZM. Metabolic signatures imaged in cancer-induced cachexia. Cancer Res. 71: 6948-56, (2011). PMCID:PMC3217079
Chen Z*, Penet MF*, Nimmagadda S, Li C, Banerjee SR, Winnard PT Jr, Artemov D, Glunde K, Pomper MG, Bhujwalla ZM. PSMA-Targeted Theranostic Nanoplex for Prostate Cancer Therapy. ACS Nano. 6: 7752-62, (2012). PMCID:PMC4066818.
Penet MF, Shah T, Bharti S, Krishnamachary B, Artemov D, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM. Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism. Clin Cancer Res. 21: 386-95, (2015). PMCID:PMC4297549
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