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Lili Ayala Barouch, M.D.

Lili Ayala Barouch, M.D.

Headshot of Lili Ayala Barouch
  • Director, Columbia Heart Failure Clinic
  • Associate Professor of Medicine
Female

Expertise

Cardiac Sarcoidosis, Cardiomyopathy, Cardiovascular Disease, Cardiovascular Disease in Women, Chemotherapy-Induced Cardiomyopathy, Congestive Heart Failure (CHF), Heart Disease, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Ischemic Heart Disease, Mechanical Circulatory Support, Peripartum Cardiomyopathy, Sports Cardiology ...read more

Research Interests

Obesity and congestive heart failure; Leptin signaling and cardiac hypertrophy; Beta 3 adrenergic signaling and cardiac remodeling; Cardioprotective effect of beta-3 adrenergic receptor signaling ...read more

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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Locations

Johns Hopkins Cardiology - Columbia

Appointment Phone: 410-964-5303
5450 Knoll North Drive
Columbia, MD 21045 map
Phone: 410-964-5303 | Fax: 410-964-5329

Background

Dr. Barouch is Associate Professor of Medicine in the Division of Cardiology, Department of Medicine, and a member of the Advanced Heart Failure and Cardiac Transplantation group at Johns Hopkins Hospital. Dr. Barouch received her undergraduate degree from Harvard University in 1992 and her medical degree from Johns Hopkins in 1996. She continued at Johns Hopkins for residency training in Internal Medicine, completed in 1999, and fellowship in Cardiovascular Disease and Advanced Heart Failure/Transplant, completed in 2003.

She has expertise in the outpatient management of advanced heart failure and many types of cardiomyopathies. Dr. Barouch also has a longstanding interest in women’s cardiovascular health – particularly in how some cardiac conditions affect women differently or present with distinctive symptoms. She is the Medical Director of the Columbia Heart Failure Clinic, in partnership with Howard County General Hospital, and the Howard County Director of the Women’s Cardiovascular Health Center. She is also the Director of the Sports Cardiology Program, which offers expert cardiac care specifically geared towards athletes of all abilities.

Dr. Barouch believes that educating people about heart disease, medications and lifestyle changes, including healthy eating habits and regular exercise, is critically important in helping her patients understand how to achieve and maintain wellness and feel in control of their cardiovascular health. She is an avid runner and triathlete herself, competing in several triathlons and other races per year, as well as the occasional marathon.

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Titles

  • Director, Columbia Heart Failure Clinic
  • Director, Sports Cardiology Program
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Johns Hopkins University School of Medicine (1996)

Residencies

  • Internal Medicine; Johns Hopkins University School of Medicine (1999)

Fellowships

  • Cardiology; Johns Hopkins University School of Medicine (2003)

Board Certifications

  • American Board of Internal Medicine (Advanced Heart Failure and Transplant Cardiology) (2010)
  • American Board of Internal Medicine (Cardiovascular Disease) (2003)

Research & Publications

Research Summary

Dr. Barouch’s prior laboratory research was focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program has enhanced the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function. The lab also worked to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work enabled the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

Selected Publications

View all on PubMed

Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature. 2002; 416:337-339

Barouch LA, Gao D, Chen L, Miller KL, Xu W, Phan AC, Kittleson MK, Minhas KM, Berkowitz DE, Wei C, Hare JM. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation Research. 2006; 98(1):119-24

Watts VL, Sepulveda FM, Cingolani OH, Ho AS, Niu X, Kim R, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Rameau G, O'Rourke B, Kass DA, Barouch LA. Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation. J Mol Cell Cardiol. 2013; 62:8-17

Barouch LA. Progress for peripartum cardiomyopathy. Trends in Cardiovascular Medicine. 2015; 25(5):407-8

Jiang W, Siddiqui S, Barnes S, Barouch LA, Korley F, Martinez DA, Toerper M, Cabral S, Hamrock E, Levin S. Readmission risk trajectories for patients with heart failure using a dynamic prediction approach: retrospective study. JMIR Med Inform. 2019; 7(4):e14756

Activities & Honors

Honors

  • Trainee Abstract Award, American Heart Association Council on Basic Cardiovascular Sciences, 2001
  • 1st Place, Fellow Division, Mid-Atlantic Cardiovascular Research Competition, 2001
  • Bristol-Myers-Squibb Travel Award, American College of Cardiology Scientific Session, 2002
  • Finalist, Fellow Basic Science Poster Award, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2002
  • Trainee Best Poster Award, American Society for Clinical Investigation and American Academy of Physicians Joint Meeting, 2003
  • Fellow Basic Science Poster Award, and Facilitated Poster Session on Obesity/Metabolism, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2003
  • Finalist, Poster Competition in Basic Sciences, American Heart Association Scientific Sessions, 2004
  • Sponsored Young Investigator, GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease Symposium: New Frontiers in Genomics and Cardiovascular Disease, 2005
  • Junior Faculty Basic Science Poster Award, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2005
  • Finalist, Northwestern Cardiovascular Forum Young Investigators Award, Junior Faculty Division, 2008
  • Fellow of the American Heart Association, American Heart Association, 2009
  • Fellow of the American College of Cardiology, American College of Cardiology, 2010
  • Member, Miller Coulson Academy of Clinical Excellence, Miller Coulson Academy of Clinical Excellence, 2021

Memberships

  • American College of Cardiology, 1999
  • American College of Cardiology Women in Cardiology Section, 2004
  • American Heart Association, 1999
  • American Heart Association Council on Clinical Cardiology, 2018
  • Heart Failure Society of America, 2009
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