Lawrence Richard Kleinberg, M.D.

Headshot of Lawrence Richard Kleinberg
  • Vice Chair of Clinical Research
  • Associate Professor of Radiation Oncology and Molecular Radiation Sciences


Brain Metastases, Brain Tumors, Cancer, Esophageal Cancer, Glioblastoma, Gliomas, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Neurology, Neurosurgery, Radiation Oncology, Spinal Metastases, Stereotactic Radiosurgery more

Research Interests

Improving therapy for brain metastases; Improved imaging of brain tumors; Drug and radiation therapy for esophageal cancer; Radiation and drug therapy for primary brain tumors more

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-502-8000
401 N. Broadway
Baltimore, MD 21231
Phone: 410-614-2597 | Fax: 410-502-1419
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center - Google Maps


Dr. Kleinberg specializes in the radiation treatments, including stereotactic radiosurgery, of brain and spinal tumors. Areas of research include both tumors arising in the central nervous system and tumors metastasizing from other locations. He also specializes in the treatment of esophageal tumors and has led national clinical trials in both therapy of brain tumors as well as esophageal cancer.

Dr. Kleinberg has been recently named in the US News and World Report list of top 1% of doctors in his specialty. He is the co-chair of the Eastern Cooperative Oncology Group Brain Tumor Working Group, Vice-Chair of the NCI Cooperative Group Steering Committee for Esophageal and Gastric Tumors, and is a member of the NCI Cooperative Group Steering Committee for Gastrointestinal Tumors. He is also on the American College of Radiation Oncology Neurologic Cancer Practice Accreditation Team.

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  • Vice Chair of Clinical Research
  • Associate Professor of Radiation Oncology and Molecular Radiation Sciences
  • Associate Professor of Neurosurgery
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes



  • MD; Yale School of Medicine (1989)


  • Radiation Oncology; Memorial Sloan-Kettering Cancer Center (1993)

Board Certifications

  • American Board of Radiology (Radiation Oncology) (1994)

Research & Publications

Selected Publications

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Heath, E.I.; Burtness, B.A.; Kleinberg, L.; Salem, R.R.; Yang, S.C.; Heitmiller, R.F.; Canto, M.I.; Knisely, J.P.; Topazian, M.; Montgomery, E.; Tsottles, N.; Pithavala, Y.; Rohmiller, B.; Collier, M.; Forastiere, A.A. Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. Invest New Drugs. 2006 Mar;24(2):135-140.

Kleinberg, L.; Gibson, M.; Yang, S.; Forastiere, A.A.; Putnam, J.B. Primary Combined Modality Therapy for Esophageal Cancer. Oncology. 2006;20(5):505-511.

Donawho, C.K.; Luo, Y.; Luo, Y.; Penning, T.D.; Bauch, J.L.; Bouska, J.J.; Bontcheva-Diaz, V.D.; Cox, B.F.; DeWeese, T.L.; Dillehay, L.E.; Ferguson, D.C.; Ghoreishi-Haack, N.S.; Grimm, D.R.; Guan, R.; Han, E.K.; Holley-Shanks, R.R.; Hristov, B.; Idler, K.B.; Jarvis, K.; Johnson, E.F.; Kleinberg, L.R.; Klinghofer, V.; Lasko, L.M.; Liu, X.; Marsh, K.C.; McGonigal, T.P.; Meulbroek, J.A.; Olson, A.M.; Palma, J.P.; Rodriguez, L.E.; Shi, Y.; Stavropoulos, J.A.; Tsurutani, A.C.; Zhu, G.D.; Rosenberg, S.H.; Giranda, V.L.; Frost, D.J. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 May 1;13(9):2728-2737.

Gerber, D.E.; Grossman, S.A.; Zeltzman, M.; Parisi, M.A.; Kleinberg, L. The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro-oncology. 2007 Jan;9(1):47-52.

Kleinberg, L.; Forastiere, A.A. Chemoradiation in the management of esophageal cancer. J Clin Oncol. 2007 Sep 10;25(26):4110-4117.

Kleinberg, L.; Gibson, M.K.; Forastiere, A.A. Chemoradiotherapy for localized esophageal cancer: regimen selection and molecular mechanisms of radiosensitization. Nature clinical practice. 2007 May;4(5):282-294.

Kretschmar, C.; Kleinberg, L.; Greenberg, M.; Burger, P.; Holmes, E.; Wharam, M. Pre-radiation chemotherapy with response-based radiation therapy in children with central nervous system germ cell tumors: a report from the Children''s Oncology Group. Pediatric blood & cancer. 2007 Mar;48(3):285-291.

Lawson, H.C.; Sampath, P.; Bohan, E.; Park, M.C.; Hussain, N.; Olivi, A.; Weingart, J.; Kleinberg, L.; Brem, H. Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience. Journal of neuro-oncology. 2007 May;83(1):61-70.

Ford, E.; Purger, D.; Tryggestad, E.; McNutt, T.; Christodouleas, J.; Rigamonti, D.; Shokek, O.; Won, S.; Zhou, J.; Lim, M.; Wong, J.; Kleinberg, L. A virtual frame system for stereotactic radiosurgery planning. International journal of radiation oncology, biology, physics. 2008 Nov 15;72(4):1244-1249.

Kleinberg, L.R.; Brock, M.V.; Jagannath, S.B.; Forastiere, A.A. Cancer of the Esophagus. In: Abeloff, M.e.a., editor. 4th Edition ed, Clinical Oncology. New York, NY: Churchill-Livingstone; 2008.

Lin, S.H.; Kleinberg, L.R. Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert review of anticancer therapy. 2008 Mar;8(3):343-359.

Guss, Z.D.; Batra, S.; Li, G.; Chang, S.D.; Parsa, A.T.; Rigamonti, D.; Kleinberg, L.; Lim, M. Radiosurgery for glomus jugulare: history and recent progress. Neurosurg Focus. 2009 Dec;27(6):E5.

McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.

Meguid, R.A.; Hooker, C.M.; Taylor, J.T.; Kleinberg, L.R.; Cattaneo, S.M., 2nd; Sussman, M.S.; Yang, S.C.; Heitmiller, R.F.; Forastiere, A.A.; Brock, M.V. Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response? J Thorac Cardiovasc Surg. 2009 Dec;138(6):1309-1317.

Frazier, J.L.; Batra, S.; Kapor, S.; Vellimana, A.; Gandhi, R.; Carson, K.A.; Shokek, O.; Lim, M.; Kleinberg, L.; Rigamonti, D. Stereotactic radiosurgery in the management of brain metastases: an institutional retrospective analysis of survival. International journal of radiation oncology, biology, physics. 2010;76(5):1486-1492.

Li, S.; Kleinberg, L.R.; Rigamonti, D.; Wharam, M.D., Jr.; Rashid, A.; Jackson, J.; Djajaputra, D.; He, S.; Creasey, T.; DeWeese, T.L. Clinical results of a pilot study on stereovision-guided stereotactic radiotherapy and intensity modulated radiotherapy. Technol Cancer Res Treat. 2010 Dec;9(6):603-617.

Tryggestad, E.; Christian, M.; Ford, E.; Kut, C.; Le, Y.; Sanguineti, G.; Song, D.Y.; Kleinberg, L. Inter- and Intrafraction Patient Positioning Uncertainties for Intracranial Radiotherapy: A Study of Four Frameless, Thermoplastic Mask-Based Immobilization Strategies Using Daily Cone-Beam CT. Int J Radiat Oncol Biol Phys. 2010 Oct 15.
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