Lawrence John Appel, M.D., M.P.H.

Headshot of Lawrence John Appel
  • Director, Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University
  • Professor of Medicine


High Blood Pressure (Hypertension), Internal Medicine more

Research Interests

Hypertension; Cardiovascular and Kidney Disease Prevention; Lifestyle Modification more

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Johns Hopkins University

Appointment Phone: 410-955-3613
2024 East Monument Street
Baltimore, MD 21205
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I am currently Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a large interdisciplinary research unit that bridges the Schools of Medicine and Public Health at Hopkins.  The mission of the Welch Center is to conduct interdisciplinary research of the highest quality and to train the next generation of clinical, epidemiologic, and translational researchers.  As for my own research, I have conducted clinical research with a particular focus on preventing blood pressure-related cardiovascular and kidney diseases. I have three active lines of research: (1) controlled feeding studies, (2) behavioral intervention trials, that test novel strategies to accomplish lifestyle changes and (3) cohort studies and trials related to chronic kidney disease and its consequences. I have also been actively involved in evidence synthesis and policy-making related to lifestyle modification as a means to prevent and treat cardiovascular-renal diseases. Over the course of my career, I have continually mentored numerous students, fellows and junior faculty - I truly enjoy this aspect of my career.

Dr. Appel was the lead in research that concluded in the DASH diet (Dietary approaches to stop hypertension), which is a dietary pattern promoted by NIH. more


  • Director, Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University
  • The C. David Molina, M.D., M.P.H. Professor of Medicine, Epidemiology and International Health
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; New York University School of Medicine (1981)


  • Internal Medicine; Johns Hopkins University School of Medicine (1989)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (1984)

Research & Publications

Selected Publications

Fakhouri TH, Jahren AH, Appel LJ, Chen L, Alavi R, Anderson CA. Serum Carbon Isotope Values Change in Adults in Response to Changes in Sugar-Sweetened Beverage Intake. J Nutr. 2014 Jun;144(6):902-5. PMID: 24717368.


Hikmat F, Appel LJ. Effects of the DASH diet on blood pressure in patients with and without metabolic syndrome: results from the DASH trial. J Hum Hypertens. 2014 Mar;28(3):170-5. PMID: 24067348.

Chang AR, Lazo M, Appel LJ, Gutiérrez OM, Grams ME. High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III. Am J Clin Nutr. 2014 Feb;99(2):320-7. PMID: 24225358.

Miller ER 3rd, Juraschek SP, Anderson CA, Guallar E, Henoch-Ryugo K, Charleston J, Turban S, Bennett MR, Appel LJ. The Effects of n-3 Long-Chain Polyunsaturated Fatty Acid Supplementation on Biomarkers of Kidney Injury in Adults With Diabetes: Results of the GO-FISH trial. Diabetes Care 2013;36:1462-1469. PMCID: 3661851.

Daumit GL, Dickerson FB, Wang NY, Dalcin A, Jerome GJ, Anderson CA, Young DR, Frick KD, Yu A, Gennusa JV 3rd, Oefinger M, Crum RM, Charleston J, Casagrande SS, Guallar E, Goldberg RW, Campbell LM, Appel LJ. A behavioral weight-loss intervention in persons with serious mental illness. N Engl J Med. 2013 Apr 25;368(17):1594-602. PMID:23517118.

Appel LJ, Clark JM, Yeh HC, Wang NY, Coughlin JW, Daumit G, Miller ER 3rd, Dalcin A, Jerome GJ, Geller S, Noronha G, Pozefsky T, Charleston J, Reynolds JB, Durkin N, Rubin RR, Louis TA, Brancati FL.  Comparative effectiveness of weight-loss interventions in clinical practice. NEJM 2011;365:1959-68.  PMID: 22085317

Appel LJ, Wright JT, Greene T, Agodoa LY, Astor BC<Bakris GL, Cleveland WH, Charleston J, Contreras G, Faulkner ML, Gabbai FB, Gassman JJ, Hebert LA, Jamerson KA, Kopple JD, Kusek JW, Lash JP, Lea JP, Lewis JB, Lipkowitz MS, Massry SG, Miller ER, Norris K, Phillips RA, Pogue VA, Randall OS, Rostand SG, Smogorzewski MJ, Toto RD, Wang X.  Intensive blood-pressure control in hypertensive chronic kidney disease. NEJM 2010:363(10):918-929. PMCID: 3662974.

Lloyd-Jones D, Hong Y, Labarthe D, Mozaffarian, D, Appel L, Van Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, Arnett DK, Fonarow GC, Ho PM, Lauer MS, Masoudi FA, Robertson RM, Roger V, Schwamm LH, Sorlie P, Yancy CW, Rosamond WD.  Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction: The American Heart Association’s Strategic Impact Goal Through 2020 and Beyond. Circulation. 2010;121:586-613. PMID: 20089546           

Hollis JF, Gullion CM, Stevens VJ, Brantley PJ, Appel LJ, Ard JD, Champagne CM, Dalcin A, Erlinger TP, Funk K, Laferriere D, Lin PH, Loria CM, Samuel-Hodge C, Vollmer WM, Svetkey LP.  Weight Loss Maintenance Trial Research Group. Weight loss during the intensive intervention phase of the weight-loss maintenance trial. Am J Prev Med. 2008 Aug;35(2):118-26. PMCID: 2515566.

Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Bullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Gerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J,  Weight Loss Maintenance Collaborative Research Group. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA. 2008 Mar 12;299(10):1139-48. PMID: 18334689

Appel LJ, Brands MW , Daniels SR, Karanja N, Elmer PJ, Sacks FM. Dietary Approaches to Prevent and Treat Hypertension: A Scientific Statement from the Am Heart Assoc.  Hypertension 2006; 47:296-308 PMID: 16434724.

Appel LJ, Sacks FM, Carey V, Lbarzanek E, Swain JF, Miller ER 3rd, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J, McCarron P, Bishop LM. The Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids: Results of the OmniHeart Randomized Trial.  JAMA, 2005; 294:2455-64. PMID: 16287956

PREMIER Collaborative Research Group (L. Appel, chair, writing group).  Effects of Comprehensive Lifestyle Modification on Blood Pressure Control JAMA. 2003;289:2083-93. PMID: 12709466

Jones DW, Appel LJ, Sheps SG, Roccella EJ.  Measuring blood pressure accurately: New and persistent challenges.  JAMA 2003; 289:1027-1030. PMID: 12597757

Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. NEJM 1997;336:1117-24.PMID: 9099655D.        

Activities & Honors


  • National Award for Career Achievement and Contribution to Clinical and Translational Science, 2012

Professional Activities

  • Chair, AHA Nutrition Committee, 2006 - 2008
  • Chair, IOM Committee on Dietary Reference Intakes for Electrolytes and Water, 2002 - 2004
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