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Larry William Chang, M.D., M.P.H.

Headshot of Larry William Chang
  • Director, Inter-Center for AIDS Research Sub-Saharan Africa Working Group
  • Associate Professor of Medicine

Languages: English, Chinese


HIV/AIDS, Infectious Disease, Infectious Diseases

Research Interests

HIV implementation science; HIV/AIDS Systematic Reviews and Guideline Development more

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Dr. Larry Chang is an Associate Professor of Medicine at the Johns Hopkins University School of Medicine. His area of clinical expertise is infectious diseases, with a special focus on HIV. He also holds joint appointments in epidemiology and international health in the Johns Hopkins Bloomberg School of Public Health.

Dr. Chang received his medical degree and a master’s in public health from Emory University. He completed his residency training in internal medicine at the University of California-San Francisco and completed his fellowship in infectious diseases at the Johns Hopkins University School of Medicine. He joined the Johns Hopkins faculty in 2009.

His primary research interest is HIV implementation science with a focus on how best to implement HIV/AIDS treatment and prevention interventions in resource-constrained settings. He is a PI of the Rakai Health Sciences Program in Uganda.

Dr. Chang is Director of the Inter-Center for AIDS Research Sub-Saharan Africa Working Group and Director of the the Johns Hopkins Center for AIDS Research Implementation Science Scientific Working Group. He is a founder and Associate Director of the Johns Hopkins Global mHealth Initiative.

Dr. Chang is a member of the International AIDS Society, and the Infectious Diseases Society of America. more


  • Director, Inter-Center for AIDS Research Sub-Saharan Africa Working Group
  • Associate Director, Johns Hopkins Global mHealth Initiative
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD MPH; Emory University School of Medicine (2002)


  • Internal Medicine; University of California San Francisco School of Medicine (2005)


  • Infectious Diseases; Johns Hopkins University School of Medicine (2009)

Research & Publications

Research Summary

Dr. Chang’s primary research focus is HIV implementation science, specifically how to best implement HIV/AIDS treatment and prevention interventions (e.g., antiretroviral therapy) in resource-constrained settings. He has conducted randomized, controlled trials, observational studies and systematic reviews in this field. 

A related research area is mHealth (mobile health technology) strategies for improving global health and clinical care. Dr. Chang’s research is multidisciplinary, using mixed methods (quantitative and qualitative), and integrating behavioral science and economic evaluations with patient-oriented outcomes research.

Selected Publications

Linas BS, Latkin C, Genz A, Westergaard RP, Chang LW, Bollinger RC, Kirk GD. “Utilizing mHealth methods to identify patterns of high risk illicit drug use.” Drug Alcohol Depend. 2015 Jun 1;151:250-7. doi: 10.1016/j.drugalcdep.2015.03.031. Epub 2015 Apr 5.

Ferrada MA, Chang L. “A man with skin lesions and ataxia: a case of disseminated varicella zoster.” Int J Infect Dis. 2015 Apr;33:55. doi: 10.1016/j.ijid.2014.10.021. Epub 2014 Nov 13/

Linas BS, Latkin C, Westergaard RP, Chang LW, Bollinger RC, Genz A, Kirk GD. “Capturing illicit drug use where and when it happens: an ecological momentary assessment of the social, physical and activity environment of using versus craving illicit drugs.” Addiction. 2015 Feb;110(2):315-25. doi: 10.1111/add.12768. Epub 2014 Nov 20.

Reynolds SJ, Sempa JB, Kiragga AN, Newell K, Nakigozi G, Galiwango R, Gray R, Quinn TC, Serwadda D, Chang L. “Is CD4 monitoring needed among ugandan clients achieving a virologic and immunologic response to treatment?” AIDS Patient Care STDS. 2014 Nov;28(11):575-8. doi: 10.1089/apc.2014.0086. Epub 2014 Oct 7.

Burkey MD, Weiser SD, Fehmie D, Alamo-Talisuna S, Sunday P, Nannyunja J, Reynolds SJ, Chang LW. “Socioeconomic determinants of mortality in HIV: evidence from a clinical cohort in Uganda.” J Acquir Immune Defic Syndr. 2014 May 1;66(1):41-7. doi: 10.1097/QAI.0000000000000094.

Activities & Honors


  • Johns Hopkins Department of Medicine Research Retreat Clinical Fellow Abstract Honorable Mention, 2009
  • Society of General Internal Medicine, Clinical Vignette Award Winner,, 2004
  • Centers for Disease Control and Prevention Hubert Fellow, 2001
  • The American Federation for Clinical Research Award, 1999


  • Member, Infectious Diseases Society of America (IDSA), 2006
  • Member, International AIDS Society (IAS), 2000

Videos & Media

Recent News Articles and Media Coverage

Exploring the Role of Mobile Technology as a Health Care Helper,” The New York Times, May 13, 2012

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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