Koko Ishizuka, M.D., Ph.D.

  • Assistant Professor of Psychiatry and Behavioral Sciences

Research Interests

Neuropsychiatric diseases; Brain development; Therapeutic intervention; Bipolar disorder; Schizophrenia ...read more


Ishizuka received an M.D. and a Ph.D. in neuropsychiatry from Kumamoto University and worked as a psychiatrist at Kumamoto University Hospital. Ishizuka had further training of basic/translational neuroscience as a fellow at Laboratory for Alzheimer''s Disease in RIKEN and in the Department of Psychiatry and Behavior Sciences at Johns Hopkins University.

...read more


  • Assistant Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Centers & Institutes

  • Molecular Psychiatry Program



  • Ph.D.; Kumamoto University Graduate School of Medical Sciences (Japan) (1997)
  • M.D.; Kumamoto University Medicine School - Kumamoto - (Japan) (1991)

Additional Training

  • RIKEN, Lab of Alzheimer''s disease, Japan, Japan, 2004; Johns Hopkins University, Baltimore, Maryland, 2009; University of Kumamoto, Kumamoto, Japan, 2003, Resident, Clinical Staff in Psychiatry

Research & Publications

Research Summary

I have conducted research at the interface of clinical psychiatry and basic neuroscience using a multi-faceted approach, including human neurons, brain imaging, and clinical assessments.

Selected Publications

View all on PubMed

Coughlin JM, Ishizuka K, Kano SI, Edwards JA, Seifuddin FT, Shimano MA, Daley EL, Zandi PP, Leweke FM, Cascella NG, Pomper MG, Yolken RH, Sawa A. Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Mol Psychiatry. 2013;18:10-11.

Ishizuka K, Kamiya A, Oh E.C, Kanki H, Seshadri S, Robinson J.F, Murdoch H, Dunlop A. J, Kubo K, Furukori K, Huang B, Zeledon M, Hayashi-Takagi A, Okano H, Nakajima K, Houslay M. D, Katsanis N, Sawa, A. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. 2011;473:92-96.

Ishizuka K, Tajinda K, Colantuoni C, Morita M, Winicki J, Le C, Lin S, Schretlen D, Sawa A, Cascella NG. Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test. Neurosci Res. 2010;66(1):106-110.

Tajinda K*, Ishizuka K*, Colantuoni C, Morita M, Winicki J, Le C, Lin S, Schretlen D, Sawa A, Cascella NG. Neuronal biomarkers from patients with mental illnesses: a novel method through nasal biopsy combined with laser-captured microdissection. Mol Psychiatry. 2010;15(3):231-232. *equal contribution.

Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci. 2010;13(3):327-332.

Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom TY, Rao S, Ishizuka K, Wong P, Korth C, Anton ES, Sawa A. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010;107(12):5622-5627.

Contact for Research Inquiries

Johns Hopkins University School of Medicine
Department of Psychiatry and Behavioral Sciences
Meyer Building
Baltimore, MD 21287 map
Phone: 410-614-1780
Fax: 410-614-1792

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