Jun Hua, Ph.D.

Headshot of Jun Hua
  • Associate Professor of Radiology and Radiological Science

Research Interests

Imaging technology development, Applications in brain diseases ...read more


Dr. Hua received his master's (2005) and doctoral (2009) degrees in biomedical engineering and electrical engineering at the Johns Hopkins University. His doctoral training centered on the development of novel MRI technologies for in vivo physiological imaging in the brain, such as protein content and cerebral blood volume.

After completing a post-doctoral fellowship in the Department of Radiology at the Johns Hopkins University from 2009 to 2010, Dr. Hua became a faculty member in the Department of Radiology at Johns Hopkins University School of Medicine and Kennedy Krieger Institute.

...read more


  • Associate Professor of Radiology and Radiological Science

Departments / Divisions

Centers & Institutes



  • Ph.D.; Johns Hopkins University (Maryland) (2009)
  • B.S.; Shanghai University of Technology (China) (2000)

Research & Publications

Research Summary

Dr. Hua’s research has centered on the development of novel MRI technologies for in vivo functional and physiological imaging in the brain, and the application of such methods for studies in healthy and diseased brains. These include the development of human and animal MRI methods to measure functional brain activities, cerebral perfusion and oxygen metabolism at high (3 Tesla) and ultra-high (7 Tesla and above) magnetic fields. He is particularly interested in novel MRI approaches to image small blood and lymphatic vessels in the brain. Collaborating with clinical investigators, these techniques have been applied 1) to detect functional, vascular and metabolic abnormalities in the brain in neurodegenerative diseases such as Huntingdon’s disease (HD), Parkinson’s disease (PD), Alzheimer’s disease (AD) and mental disorders such as schizophrenia; and 2) to map brain functions and cerebrovascular reactivity for presurgical planning in patients with vascular malformations, brain tumors and epilepsy. 

Selected Publications

Selected Peer-reviewed Journal Articles:

1)     Hua J, Jones CK, Blakeley J, Van Zijl PCM, Zhou J. Quantitative Description of the Asymmetry in Magnetization Transfer Effects in the Human Brain. Magnetic Resonance in Medicine 58:786-793, 2007. PMC3707117.

2)     Zhou J, Blakeley J, Hua J, Kim M, Laterra J, Pomper MG, Van Zijl PCM. A Practical Data Acquisition Method for Human Brain Amide Proton Transfer (APT) Imaging with B0 Inhomogeneity Correction at 3T. Magnetic Resonance in Medicine 60:842-849, 2008. PMC2579754.

3)     Hua J, Donahue MJ, Zhao JM, Grgac K, Huang AJ, Zhou J, Van Zijl PCM. Magnetization Transfer (MT) Enhanced Vascular Space Occupancy (VASO) fMRI. Magnetic Resonance in Medicine 61:944-951, 2009. PMC2728078.

4)     Ng MC, Hua J, Hu Y, Luk KD, Lam EY. Magnetization Transfer (MT) Asymmetry Around the Water Resonance in Human Cervical Spinal Cord. Journal of Magnetic Resonance Imaging 29:523-528, 2009. PMID:19243033.

5)     Donahue MJ, Hua J, Pekar JJ, Van Zijl PCM. The Effect of Blood Inflow on Vascular-space-occupancy (VASO) Contrast. Magnetic Resonance in Medicine 61:473-480, 2009. PMC2632724.

6)     Hua J, Qin Q, Donahue MJ, Zhou J, Pekar JJ, Van Zijl PCM. Inflow-based Vascular Space Occupancy (VASO) MRI. Magnetic Resonance in Medicine 66:40-56, 2011. PMC3121008.

7)     Hua J, Qin Q, Pekar JJ, Van Zijl PCM. Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent. NMR in Biomedicine 24(10):1313-25, 2011. PMC3192228.

8)     Hua J, Stevens R, Huang AJ, Pekar JJ, Van Zijl PCM. Physiological origin for the BOLD poststimulus undershoot in human brain: vascular compliance versus oxygen metabolism. Journal of Cerebral Blood Flow and Metabolism 31:1599-611, 2011. PMC3137471.

9)     Landman BA, Huang AJ, Gifford A, Vikram DS, Lim IAL, Farrell JAD, Bogovic JA, Hua J, Chen M, Jarso M, Smith SA, Joel S, Mori S, Pekar JJ, Barker PB, Prince JL, Van Zijl PCM. Multi-parametric Neuroimaging Reproducibility: a 3T Resource Study. Neuroimage 54:2854-66, 2011. PMC3020263.

10)  Zaca D, Hua J, Pillai JJ. Cerebrovascular reactivity mapping for brain tumor presurgical planning. World J Clin Oncol. 2:289-98, 2011. PMC3139032.

11)  Jones CK, Polders D, Hua J, Zhu H, Hoogduin HJ, Zhou J, Luijten P, Van Zijl PCM. In Vivo 3D Whole-Brain Pulsed Steady State Chemical Exchange Saturation Transfer at 7T. Magnetic Resonance in Medicine 67(6):1579-89, 2012. PMC3291747.

12)  Van Zijl PCM, Hua J, Lu H. The BOLD post-stimulus undershoot, one of the most debated issues in fMRI. Neuroimage 62:1092-1102, 2012. PMC3356682.

13)  Yadav NN, Jones CK, Hua J, Xu J, Van Zijl PCM. Imaging of Endogenous Exchangeable Proton Signals in the Human Brain Using Frequency Labeled Exchange Transfer Imaging. Magnetic Resonance in Medicine 69(4):966-973, 2013. PMC3606647.

14)  Hua J, Jones CK, Qin Q, Van Zijl PCM. Implementation of Vascular-space-occupancy (VASO) MRI at 7 Tesla. Magnetic Resonance in Medicine 69(4):1003-13, 2013. PMC4121129.

15)  Yau JM, Hua J, Liao DA, Desmond JE. Efficient and robust identification of cortical targets in concurrent TMS-fMRI experiments. Neuroimage 76:134-44, 2013. PMC3982315.

16)  Jones CK, Huang AJ, Xu J, Edden RAE, Schar M, Hua J, Oskolkov N, Zaca D, Zhou J, McMahon MT, Pillai JJ, Van Zijl PCM. Nuclear Overhauser Enhancement (NOE) Imaging in the Human Brain at 7T. Neuroimage 77:114-24, 2013. PMC3848060.

17)  Lu H, Hua J, Van Zijl PCM. Non-invasive functional imaging of Cerebral Blood Volume with Vascular-Space-Occupancy (VASO) MRI. NMR in Biomedicine 26(8):932-48, 2013. PMC3659207.

18)  Unschuld PG, Liu X, Shanahan M, Margolis RL, Bassett SS, Brandt J, Schretlen DJ, Redgrave GW, Hua J, Hock C, Reading SA, Van Zijl PCM, Pekar JJ, Ross CA. Altered prefrontal network connectivity during a motor planning task in prodromal Huntington's disease. Cortex 49(10):2661-73, 2013. PMID23906595.

19)  Qin Q, Huang AJ, Hua J, Desmond JE, Stevens RD, Van Zijl PCM. 3D Whole-Brain Perfusion Quantification using Pseudo-Continuous Arterial Spin Labeling MRI at Multiple Post-Labeling Delays: Accounting for Both Arterial Arrival Time and Impulse Residue Function. NMR in Biomedicine 27(2):116-28 2014. PMC3947417.

20)  Hua J, Unschuld PG, Margolis RL, Van Zijl PCM, Ross CA. Elevated Arteriolar Cerebral Blood Volume in Prodromal Huntington’s Disease Patients. Movement Disorders 29(3):396-401 2014. PMC3834086.

21)  Hua J, Qin Q, Van Zijl PCM, Pekar JJ, Jones CK. Whole-brain three-dimensional T2-weighted BOLD functional magnetic resonance imaging at 7 Tesla. Magnetic Resonance in Medicine 2014 Dec;72(6):1530-40. PMC4055555.

22)  Cheng Y, Van Zijl PCM, Pekar JJ, Hua J*. Three-dimensional Acquisition of Cerebral Blood Volume and Flow Responses during Functional Stimulation in a Single Scan. Neuroimage 2014 Dec;103:533-41. PMC4252776.

23)  Cheng Y, Van Zijl PCM, Hua J*. Measurement of Parenchymal Extravascular R2* and Tissue Oxygen Extraction Fraction Using Multi-echo VASO MRI at 7 Tesla. NMR in Biomedicine 2015 Feb;28(2):264-71. PMC4297270.

24)  Xu J, Qin Q, Wu D, Hua J, Song X, McMahon MT, Northington FJ, Zhang J, Van Zijl PCM, Pekar JJ. Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging. Magnetic Resonance in Medicine 2015 doi: 10.1002/mrm.25641. PMID25732958.

Contact for Research Inquiries

F.M. Kirby Research Center for Functional Brain Imaging
707 North Broadway
Baltimore, MD 21205 map
Phone: 443-923-0000

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