Research Summary
Dr. Xu conducts basic and translational research aimed at better understanding the roles of neural activity dependent surviving pathways in early pathogenesis of Alzheimer’s disease (AD) and inflammatory regulation in a variety of neurodegenerative disease, in which we utilize a large panel of isogenic human induced pluripotent stem cell (iPS)-derived neural cells, preclinical mouse models and state-of-the-art techniques to understand the underlying mechanisms with the goal of developing new medical interventions.
Lab
Lab Website: Jinchong Xu
Technology Expertise Keywords
Neurological Disorders, Human Pluripotent Stem Cell, Gene editing, Transcriptomics and Cellular Transplantation
Selected Publications
Yin, X*, Xu, J.-C.*, Cho, G-S., Kwon, C., Dawson, T.M., Dawson, V.L. “Neurons derived from human inducible pluripotent stem cells integrate into rat brain circuits and maintain both excitatory and inhibitory synaptic activities.” (2019) eNeuro. 6(4). PMCID: PMC6709226. (*equal contribution, article highlighted on eNeuro.org homepage).
Xu, J.-C., Fan, J., Wang, X., Eacker, S.M., Kam, T.-I., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., Chen, R., Dawson, T.M., Dawson, V.L. “Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.” (2016) Science Translational Medicine, 8 (333), art. no. ra48. PMCID: PMC5595216.
Xu, J.-C., Xiao, M.-F., Jakovcevski, I., Sivukhina, E., Hargus, G., Cui, Y.-F., Irintchev, A., Schachner, M., Bernreuther, C. “The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.” (2014) Journal of Cell Science, 127 (3), pp. 641-652. PMID: 24338367. DOI: 10.1242/jcs.137612.
Xu, J.-C., Dawson, V.L., Dawson, T.M. “Usp16 Key controller of stem cells in down syndrome.” (2013) EMBO Journal, 32 (21), pp. 2788-2789. PMCID: PMC3817468
Xu, J.-C., Bernreuther, C., Cui, Y.-F., Jakovcevski, I., Hargus, G., Xiao, M.-F., Schachner, M. “Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury.” (2011) Journal of Neurotrauma, 28 (9), pp. 1921-1937.
Patient Ratings & Comments
The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.