Neuroinflammation; Neurological Disorders; Stem Cells ...read more
Dr. Xu earned his M.D. with honors degree from Xiangya School of Medicine and completed his medicine internship and residency for neuropathology at Xiangya Hospital, Xiangya School of Medicine, China. He then received a Ph.D. from the Medicine Faculty University of Hamburg, Germany. Dr. Xu arrived at Johns Hopkins in 2010 where he completed a fellowship in neurology. In 2018, he joined the faculty of Department of Neurology, Johns Hopkins School of Medicine.
Dr. Xu conducts basic and translational research aimed at better understanding the roles of neural activity dependent surviving pathways in early pathogenesis of Alzheimer’s disease (AD) and inflammatory regulation in a variety of neurodegenerative disease, in which we utilize a large panel of isogenic human induced pluripotent stem cell (iPS)-derived neural cells, preclinical mouse models and state-of-the-art techniques to understand the underlying mechanisms with the goal of developing new medical interventions.
Lab Website: Jinchong Xu
Neurological Disorders, Human Pluripotent Stem Cell, Gene editing, Transcriptomics and Cellular Transplantation
Yin, X*, Xu, J.-C.*, Cho, G-S., Kwon, C., Dawson, T.M., Dawson, V.L. “Neurons derived from human inducible pluripotent stem cells integrate into rat brain circuits and maintain both excitatory and inhibitory synaptic activities.” (2019) eNeuro. 6(4). PMCID: PMC6709226. (*equal contribution, article highlighted on eNeuro.org homepage).
Xu, J.-C., Fan, J., Wang, X., Eacker, S.M., Kam, T.-I., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., Chen, R., Dawson, T.M., Dawson, V.L. “Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.” (2016) Science Translational Medicine, 8 (333), art. no. ra48. PMCID: PMC5595216.
Xu, J.-C., Xiao, M.-F., Jakovcevski, I., Sivukhina, E., Hargus, G., Cui, Y.-F., Irintchev, A., Schachner, M., Bernreuther, C. “The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.” (2014) Journal of Cell Science, 127 (3), pp. 641-652. PMID: 24338367. DOI: 10.1242/jcs.137612.
Xu, J.-C., Dawson, V.L., Dawson, T.M. “Usp16 Key controller of stem cells in down syndrome.” (2013) EMBO Journal, 32 (21), pp. 2788-2789. PMCID: PMC3817468
Xu, J.-C., Bernreuther, C., Cui, Y.-F., Jakovcevski, I., Hargus, G., Xiao, M.-F., Schachner, M. “Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury.” (2011) Journal of Neurotrauma, 28 (9), pp. 1921-1937.
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Phone: 410-614-6124
Experts to Study Human Tissue Models' Responses to Space Radiation, And Develop Countermeasures, Johns Hopkins Institute For Nanobiotechnology (October 2, 2020)
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