Dr. Xu conducts basic and translational research aimed at better understanding the roles of neural activity dependent surviving pathways in early pathogenesis of Alzheimer’s disease (AD) and inflammatory regulation in a variety of neurodegenerative disease, in which we utilize a large panel of isogenic human induced pluripotent stem cell (iPS)-derived neural cells, preclinical mouse models and state-of-the-art techniques to understand the underlying mechanisms with the goal of developing new medical interventions.
Lab Website: Jinchong Xu
Technology Expertise Keywords
Neurological Disorders, Human Pluripotent Stem Cell, Gene editing, Transcriptomics and Cellular Transplantation
Yin, X*, Xu, J.-C.*, Cho, G-S., Kwon, C., Dawson, T.M., Dawson, V.L. “Neurons derived from human inducible pluripotent stem cells integrate into rat brain circuits and maintain both excitatory and inhibitory synaptic activities.” (2019) eNeuro. 6(4). PMCID: PMC6709226. (*equal contribution, article highlighted on eNeuro.org homepage).
Xu, J.-C., Fan, J., Wang, X., Eacker, S.M., Kam, T.-I., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., Chen, R., Dawson, T.M., Dawson, V.L. “Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.” (2016) Science Translational Medicine, 8 (333), art. no. ra48. PMCID: PMC5595216.
Xu, J.-C., Xiao, M.-F., Jakovcevski, I., Sivukhina, E., Hargus, G., Cui, Y.-F., Irintchev, A., Schachner, M., Bernreuther, C. “The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.” (2014) Journal of Cell Science, 127 (3), pp. 641-652. PMID: 24338367. DOI: 10.1242/jcs.137612.
Xu, J.-C., Dawson, V.L., Dawson, T.M. “Usp16 Key controller of stem cells in down syndrome.” (2013) EMBO Journal, 32 (21), pp. 2788-2789. PMCID: PMC3817468
Xu, J.-C., Bernreuther, C., Cui, Y.-F., Jakovcevski, I., Hargus, G., Xiao, M.-F., Schachner, M. “Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury.” (2011) Journal of Neurotrauma, 28 (9), pp. 1921-1937.