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Jinchong Xu, Ph.D., M.Med.

Jinchong Xu, Ph.D., M.Med.

Headshot of Jinchong Xu
  • Director, Human iPS Cell Core for Neurodegenerative Disease Research, Johns Hopkins Alzheimer's Disease Research Center
  • Assistant Professor of Neurology

Research Interests

Neuroinflammation; Neurological Disorders; Stem Cells ...read more

Background

Dr. Xu earned his M.D. with honors degree from Xiangya School of Medicine and completed his medicine internship and residency for neuropathology at Xiangya Hospital, Xiangya School of Medicine, China. He then received a Ph.D. from the Medicine Faculty University of Hamburg, Germany. Dr. Xu arrived at Johns Hopkins in 2010 where he completed a fellowship in neurology. In 2018, he joined the faculty of Department of Neurology, Johns Hopkins School of Medicine.   

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Titles

  • Director, Human iPS Cell Core for Neurodegenerative Disease Research, Johns Hopkins Alzheimer's Disease Research Center
  • Assistant Professor of Neurology

Departments / Divisions

Education

Degrees

  • B.Med.; Central South University - Xiangya School of Medicine (China) (2000)
  • Ph.D.; Medicine Fak Der University Hamburg - Hamburg (Germany) (2009)
  • M. Med; Peking University (China) (2005)

Research & Publications

Research Summary

Dr. Xu conducts basic and translational research aimed at better understanding the roles of neural activity dependent surviving pathways in early pathogenesis of Alzheimer’s disease (AD) and inflammatory regulation in a variety of neurodegenerative disease, in which we utilize a large panel of isogenic human induced pluripotent stem cell (iPS)-derived neural cells, preclinical mouse models and state-of-the-art techniques to understand the underlying mechanisms with the goal of developing new medical interventions.

Lab

Lab Website: Jinchong Xu

Technology Expertise Keywords

Neurological Disorders, Human Pluripotent Stem Cell, Gene editing, Transcriptomics and Cellular Transplantation

Selected Publications

Yin, X*, Xu, J.-C.*, Cho, G-S., Kwon, C., Dawson, T.M., Dawson, V.L. “Neurons derived from human inducible pluripotent stem cells integrate into rat brain circuits and maintain both excitatory and inhibitory synaptic activities.” (2019) eNeuro. 6(4). PMCID: PMC6709226. (*equal contribution, article highlighted on eNeuro.org homepage).

Xu, J.-C., Fan, J., Wang, X., Eacker, S.M., Kam, T.-I., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., Chen, R., Dawson, T.M., Dawson, V.L. “Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.” (2016) Science Translational Medicine, 8 (333), art. no. ra48. PMCID: PMC5595216.

Xu, J.-C., Xiao, M.-F., Jakovcevski, I., Sivukhina, E., Hargus, G., Cui, Y.-F., Irintchev, A., Schachner, M., Bernreuther, C. “The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice.” (2014) Journal of Cell Science, 127 (3), pp. 641-652. PMID: 24338367. DOI: 10.1242/jcs.137612.

Xu, J.-C., Dawson, V.L., Dawson, T.M. “Usp16 Key controller of stem cells in down syndrome.” (2013) EMBO Journal, 32 (21), pp. 2788-2789. PMCID: PMC3817468

Xu, J.-C., Bernreuther, C., Cui, Y.-F., Jakovcevski, I., Hargus, G., Xiao, M.-F., Schachner, M. “Transplanted L1 expressing radial glia and astrocytes enhance recovery after spinal cord injury.” (2011) Journal of Neurotrauma, 28 (9), pp. 1921-1937.

Contact for Research Inquiries

733 N. Broadway
Miller Research Building, MRB 769
Baltimore, MD 21205-1832 map
Phone: 410-614-6124

Activities & Honors

Honors

  • Johns Hopkins Alzheimer's Disease Research Center Development Award, Johns Hopkins Alzheimer's Disease Research Center, 2021
  • CFAR Scholar Award for Faculty Development, Center for AIDS Research, 2020
  • Developmental Core Pilot Awards, NIMH Center for Novel Therapeutics, 2021
  • Stem Cell Research Fellowship Award, Maryland Stem Cell Research Fund, 2016

Memberships

  • Stroke Council, American Heart Association, 2019
  • Professional Member, American Heart Association, 2019
  • International Society for Stem Cell Research, 2013

Videos & Media

Recent News Articles and Media Coverage

Experts to Study Human Tissue Models' Responses to Space Radiation, And Develop Countermeasures, Johns Hopkins Institute For Nanobiotechnology (October 2, 2020)

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