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Jiang Qian, Ph.D., M.S.

Headshot of Jiang Qian
  • Professor of Ophthalmology

Research Interests

Retinal gene regulation

Background

Jiang Qian, Ph.D., is the Karl H. Hagen professor of ophthalmology at the Wilmer Eye Institute. His research focuses on retinal gene regulation and the application of bioinformatics to the study of gene expression and regulation.

Dr. Qian received an M.S. in computational biology from Shanghai Biochemistry Institute in Shanghai, China, and a Ph.D. in physical chemistry from the Max Planck Institute for Polymer Research in Mainz, Germany. He then completed a postdoctoral fellowship in bioinformatics at Yale University.

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Titles

  • Professor of Ophthalmology
  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; Max Planck Institute (Germany) (1999)
  • M.S.; Shanghai Institute of Biochemistry - Shanghai (China) (1994)
  • B.S.; Shanghai Jiao Tong University (China) (1991)

Additional Training

  • Yale University, New Haven, Connecticut, 2001, Bioinformatics

Research & Publications

Research Summary

The Wilmer bioinformatics lab develops and applies bioinformatics approaches to the study of gene regulation, with particular, but not exclusive, attention to the regulation of retinal gene expression. In particular, the lab is interested in understanding transcriptional networks and protein/DNA interactions.

We integrate large biological datasets and develop computational algorithms to predict regulatory mechanisms controlling coordinated gene expression in specific tissues and cell types in both development and disease.

Recently, we have been interested in analyzing gene expression, epigenetic regulation, and single-cell datasets to construct regulatory networks and cell-cell communication pathways.

Lab

Lab Website: Wilmer Bioinformatics

Selected Publications

View all on PubMed

Hoang T, Wang J, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Parayil T, Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR, Qian J, Blackshaw S. “Gene regulatory networks controlling vertebrate retinal regeneration”, Science, 2020, 370: eabb8598.

Gao T, Qian J. “EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue/cell types across nine species.”, Nucleic Acids Res. 2020 Jan 8;48(D1):D58-D64.

Hu MW, Kim DW, Liu S, Zack DJ, Blackshaw S, Qian J. “PanoView: An iterative clustering method for single-cell RNA sequencing data”, PLoS Comput Biol. 2019 Aug 30;15(8):e1007040.

Wang J, Zibetti C, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs S, Zack DJ, Handa JT, Sinha D, Blackshaw S, Qian J. “ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration”, Nat Communications, 2018, 9(1):1364.

Zhu H, Wang G, Qian J, “Transcription factors as readers and effectors of DNA methylation.” Nature Reviews Genetics, 2016, 17, 551-65.

Contact for Research Inquiries

Smith Building
400 N. Broadway
Baltimore, MD 21287 map
Phone: 443-287-3882

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