The Wilmer bioinformatics lab develops and applies bioinformatics approaches to the study of gene regulation, with particular, but not exclusive, attention to the regulation of retinal gene expression. In particular, the lab is interested in understanding transcriptional networks and protein/DNA interactions.
We integrate large biological datasets and develop computational algorithms to predict regulatory mechanisms controlling coordinated gene expression in specific tissues and cell types in both development and disease.
Recently, we have been interested in analyzing gene expression, epigenetic regulation, and single-cell datasets to construct regulatory networks and cell-cell communication pathways.
Lab Website: Wilmer Bioinformatics
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Zhu H, Wang G, Qian J, “Transcription factors as readers and effectors of DNA methylation.” Nature Reviews Genetics, 2016, 17, 551-65.