Isa Sayyeed Karim Mohammed, M.D.

Headshot of Isa Sayyeed Karim Mohammed
  • Assistant Professor of Ophthalmology



Research Interests

Refractive surgery, cataract surgery, corneal transplantation, international ophthalmology. more


The Johns Hopkins Hospital

600 N. Wolfe Street
Baltimore, MD 21287
Phone: 410-955-5490 | Fax: 410-583-2716
The Johns Hopkins Hospital - Google Maps

Johns Hopkins Wilmer Eye Institute - Frederick

161 Thomas Johnson Drive
Suite 275
Frederick, MD 21702
Johns Hopkins Wilmer Eye Institute - Frederick - Google Maps

Johns Hopkins Medicine - Green Spring Station

10753 Falls Road
Johns Hopkins Wilmer Eye Institute, Pavilion II, Suite 455
Lutherville, MD 21093
Johns Hopkins Medicine - Green Spring Station - Google Maps


Isa Sayyeed Karim Mohammed specializes in cornea, cataract and refractive surgery at the Wilmer Eye Institute, Johns Hopkins Medicine. He performs complex cataract surgery, corneal transplantation (penetrating keratoplasty, deep anterior lamellar keratoplasty, and descemet stripping automated endothelial keratoplasty and descemet membrane endothelial keratoplasty) and the entire range of refractive surgery, including laser-assisted in situ keratomileusis, photorefractive keratectomy and implantable collamer lenses surgery.

Dr. Mohammed earned an undergraduate degree in biomedical engineering at The Johns Hopkins University and then received his medical doctorate from the University of Maryland School of Medicine. He completed an ophthalmology residency at the University of Maryland Medical Center, where he received both the Outstanding Resident Award and the Malouf Resident Research Award for excellence in research. He then completed more subspecialty training in cornea and refractive surgery at the renowned Cole Eye Institute at the Cleveland Clinic. more


  • Assistant Professor of Ophthalmology

Departments / Divisions



  • MD; University of Maryland School of Medicine (2017)


  • Ophthalmology; University of Maryland Medical Center (2021)


  • Cornea/External Disease and Refractive Surgery; Cleveland Clinic Foundation (2022)

Board Certifications

  • American Board of Ophthalmology (Ophthalmology) (2022)

Research & Publications

Research Summary

Dr. Mohammed's research focuses on clinical refractive surgery in order to improve refractive outcomes for patients having cataract, corneal or refractive surgery. His research is also on the use of anterior segment optical coherence tomography to detect eyes at risk for developing corneal ectasias in order to reduce long term complications following refractive surgery. Additionally, he studies global barriers to refractive surgery and cataract surgery with hopes to reduce the worldwide burden of blindness.

Selected Publications

Lin A, Mohammed ISK, Munir WM, Munir S, Alexander J. Inter-rater Reliability of Manual Anterior Segment-OCT Image Grading in Keratoconus. Eye & Contact Lens, 2021; 47(9): 494-499.

Mohammed ISK, Tran S, Toledo-Espiett L, Munir WM. The Detection of Keratoconus Using Novel Metrics Derived by Anterior Segment Optical Coherence Tomography. International Ophthalmology, 2022 Jan; 1–10.


Lin AN, Mohammed ISK, Munir WM, Munir SZ, Maripudi S, Wei L, Alexander JL. Repeatability and Reliability of Semi-automated Anterior Segment-Optical Coherence Tomography Imaging Compared to Manual Analysis in Normal and Keratoconus Eyes. International Ophthalmology, 2023 Oct; 1–7.



Wei L, Mohammed ISK, Francomacaro S, Munir WM. Evaluating Text-based Generative Artificial Intelligence Models for Patient Information Regarding Cataract Surgery. Journal of Cataract & Refractive Surgery, Jan 2024; 50 (1).


Mohammed ISK, Jeng BH. Atypical Mycobacterial Infections. Infections of the Conjunctiva and Cornea: Das S, Jhanji V (eds). Springer Nature (in press).

Activities & Honors


  • Honors in Biomedical Engineering, The Johns Hopkins University
  • Maryland Delegate and Senatorial Scholarship, Maryland Legislature
  • Malouf Resident Research Award
  • Outstanding Resident in Ophthalmology Award


  • American Academy of Opthalmology
  • American Society of Cataract and Refractive Surgery
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