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Hyesoo Kim, D.V.M., Ph.D.

Headshot of Hyesoo Kim
  • Assistant Professor of Neurology

Research Interests

Human pluripotent stem cells (hPSCs); Cell fate determination/plasticity; Disease modeling; Optogenetic application of hPSCs ...read more

Background

Dr. Hyesoo Kim is an Assistant Professor of the Institute for Cell Engineering and the Department of Neurology. Dr. Kim received undergraduate degrees from the Ewha Womans University (Biological Science) and the Kunkuk University (Veterinary Medicine) in Seoul, South Korea. She earned her Ph.D. in Veterinary Medicine from the Seoul National University and came to the USA to complete postdoctoral work in the Lorenz Studer Lab, in the Developmental Biology Program at the Sloan Kettering Institute, New York. Dr. Kim joined the Johns Hopkins as a faculty member in 2017.

For more than 15 years, Dr. Kim has been studying human pluripotent stem cells (hPSCs) and its application for disease modeling and drug discovery. In her postdoctoral training, Dr. Kim’s research focus was to study the status of pluripotency and reprogramming in terms of neural propensity in multiple human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs). With extensive experience in hPSCs, Dr. Kim joined as a Director of Stem Cell Core Facility (SCCF) at Johns Hopkins School of Medicine, where she supported stem cell research communities inside and outside of Johns Hopkins, by sharing expertise and techniques for over 5 years. Since 2017, Dr. Kim became an Assistant Professor in the Institute for Cell Engineering, and the Kim lab is focusing on enhancing the capacity of hPSCs-based approaches.

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Titles

  • Assistant Professor of Neurology

Departments / Divisions

Education

Degrees

  • B.S.; Konkuk University (Korea) (2000)
  • D.V.M.; Konkuk University (Korea) (2000)
  • Ph.D.; Seoul National University (Korea) (2004)

Research & Publications

Research Summary

The Kim lab is focusing on enhancing the capacity of human pluripotent stem cells (hPSCs)-based approaches. For more efficient usage of hPSCs, Kim lab is trying to make several points of improvement, such as a novel approach of hiPSCs generation, innovative technology for genetic modification in hPSCs, and broader application of hPSCs as a cellular platform to cope with various disease such as muscular dystrophies, amyotrophic lateral sclerosis, and Parkinson’s disease, etc. In addition, Kim lab studies developed a new optical activating system to controlling multiple signaling pathways and cellular fates of hPSCs with a precise temporal and spatial precision.

Selected Publications

Choi IY, Lim H, Huynh A, Schofield J, Cho HJ, Lee H, Andersen P, Shin JH, Heo WD, Hyun SH, Kim YJ, Oh Y, Kim H, Lee G. Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency. Biomaterials. 2021 Feb;269:120222. doi: 10.1016/j.biomaterials.2020.120222. Epub 2020 Jul 15. PubMed PMID: 32736809

Choi IY, Lim H, Cho HJ, Oh Y, Chou BK, Bai H, Cheng L, Kim YJ, Hyun S, Kim H, Shin JH, Lee G. Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors. Elife. 2020 Feb 3;9. doi: 10.7554/eLife.46981. PubMed PMID: 32011235; PubMed Central PMCID: PMC6996923.

Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wagner KR, Lee G. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Report 2016 15(10):2301-12. PMID: 27239027

Lee G, Ramirez CN, Kim H, Zeltner N, Liu B, Radu C, Bhinder B, Kim YJ, Choi IY, Mukherjee-Clavin B, Djaballah H, Studer L. Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression. Nat Biotechnol. 2012 Dec;30(12):1244-8. doi: 10.1038/nbt.2435. Epub 2012 Nov 25. PubMed PMID: 23159879; PubMed Central PMCID: PMC3711177

Kim H, Lee G, Ganat Y, Papapetrou EP, Lipchina I, Socci ND, Sadelain M, Studer L. miR-371-3 Expression predicts neural differentiation propensity in human pluripotent stem cells. Cell Stem Cell 2011 8:695-706. PMID 21624813

Videos & Media

Lectures and Presentations

  • miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells
    Presentation, 2013 Stem Cell Research Conference
    Korean Research Institute for Biology and Biotechnology (KRIBB)
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