Howard Mark Lederman, M.D., Ph.D.

Headshot of Howard Mark Lederman
  • Director, Immunodeficiency Clinic
  • Professor of Pediatrics


Allergy and Immunology, Antibody Deficiency, Ataxia-Telangiectasia, Chronic Granulomatous Disease, Common Variable Immunodeficiency, Complement Deficiency, DiGeorge Syndrome, Gamma Globulin Therapy, Hyper-IgE Syndrome, Hyper-IgM Syndrome, Hypogammaglobulinemia, IgA Deficiency, IgM Deficiency, Leukocyte Adhesion Deficiency, Primary Immunodeficiency Diseases, Severe Combined Immunodeficiency (SCID), Wiskott-Aldrich Syndrome, X-linked Agammaglobulinemia more

Research Interests

Primary Immunodeficiency Diseases; Ataxia-Telangiectasia; IgA deficiency; Common variable immunodeficiency; Chronic granulomatous disease and other disorders of phagocytes; Severe combined immunodeficiency; Hypogammaglobulinemia; Immunoglobulin therapy; IVIG; DiGeorge syndrome; Wiskott-Aldrich syndrome; Hyper-IgM syndrome; Hyper-IgE syndrome; Complement deficiency; X-linked agammaglobulinemia; Antibody deficiency; IgM deficiency more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-5883
600 N. Wolfe Street
Sheikh Zayed Tower Suite 1102
Baltimore, MD 21287
Phone: 410-955-5883 | Fax: 410-955-0229
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Dr. Howard Lederman is a professor of pediatrics at the Johns Hopkins University School of Medicine. He is the director of the Immunodeficiency Clinic, the Pediatric Immunology Laboratory, and the Ataxia-Telangiectasia (A-T) Clinical Center.  

Dr. Lederman specializes in the evaluation, diagnostic testing and long-term management of patients of all ages who have known or suspected primary immunodeficiency diseases. He is an expert on the use of gamma globulin therapy for a wide variety of disorders. 

After receiving his M.D. and Ph.D. from the University of Michigan, Dr. Lederman came to Johns Hopkins Children’s Center for a residency in pediatrics, followed by a fellowship in immunology at the Hospital for Sick Children in Toronto. 

Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.

He is a member of numerous professional societies, including American Association of Immunologists, the American Society for Microbiology and the Clinical Immunology Society. more


  • Director, Immunodeficiency Clinic
  • Director, Ataxia-Telangiectasia Clinical Center
  • Director, Pediatric Immunology Laboratory
  • Professor of Pediatrics
  • Joint Appointment in Medicine

Departments / Divisions

Centers & Institutes



  • MD; University of Michigan Medical School (1977)


  • Pediatrics; Johns Hopkins University School of Medicine (1981)


  • Immunology; The Hospital for Sick Children (1983)

Board Certifications

  • American Board of Pediatrics (Pediatrics) (1984)

Research & Publications

Research Summary

Dr. Lederman’s current research laboratory and clinical research focuses on better understanding and treating patients with ataxia-telangiectasia, a devastating neurological disorder for which there is no cure.

Clinical Trial Keywords

Immunoglobulin; Gamma globulin; Ataxia- Telangiectasia

Clinical Trials

Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia

Selected Publications

McGrath-Morrow S, Lefton-Greif M, Rosquist K, Crawford T, Kelly A, Zeitlin P, Carson K , Lederman HM. “Pulmonary function in adolescents with ataxia-telangiectasia.” Pediatr Pulmonol. 2008 Jan;43(1):59-66.

Daniels JA, Maitra A, Lederman HM, and Montgomery E. “Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): A clinicopathologic study and review.” Am J Surg Pathol.  2007 Dec;31(12):1800-12. 

Alterman N, Fattal-Valevski A, Moyal L, Crawford TO, Lederman HM, Ziv Y, and Shiloh Y. “Ataxia-Telangiectasia: Mild neurological presentation despite null ATM mutation and severe cellular phenotype.” Am J Med Genet A.  2007 Aug 15;143A(16):1827-34.

Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA and Gern JE. “Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study.” BMC Immunol. 2006 Dec 12;7:29.

Lin, DDM, Crawford TO, Lederman HM, Barker PB. “Proton MR Spectroscopic Imaging in Ataxia-Telangiectasia.” Neuropediatrics.  2006 Aug;37(4):241-6.

Activities & Honors


  • American Association of Immunologists 
  • American Society for Microbiology 
  • Clinical Immunology Society 
  • Infectious Diseases Society of America
  • Society for Pediatric Research 
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