Research Summary
Dr. Zhu's research goals are to discover and characterize the activities of large collections of proteins to build signaling networks for better understanding the mechanisms of biological processes, and to identify biomarkers for important human diseases. More specifically, Dr. Zhu and his team are interested in analyzing protein posttranslational modifications, identifying important components involved in various signaling networks and studying host-pathogen interactions on the proteomics level.
Selected Publications
Hu S, Wan J, Su Y, Song Q, Zeng Y, Nguyen HN, Shin J, Cox E, Rho HS, Woodard C, Xia S, Liu S, Lyu H, Ming GL, Wade H, Song H, Qian J, Zhu H. "DNA methylation presents distinct binding sites for human transcription factors." Elife. 2013 Sep 3;2:e00726. doi: 10.7554/eLife.00726.
Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. "Construction of human activity-based phosphorylation networks." Mol Syst Biol. 2013;9:655. doi: 10.1038/msb.2013.12.
Jeong JS, Jiang L, Albino E, Marrero J, Rho HS, Hu J, Hu S, Vera C, Bayron-Poueymiroy D, Rivera-Pacheco ZA, Ramos L, Torres-Castro C, Qian J, Bonaventura J, Boeke JD, Yap WY, Pino I, Eichinger DJ, Zhu H, Blackshaw S. "Rapid identification of monospecific monoclonal antibodies using a human proteome microarray." Mol Cell Proteomics. 2012 Jun;11(6):O111.016253. doi: 10.1074/mcp.O111.016253. Epub 2012 Feb 3.
Lu JY, Lin YY, Sheu JC, Wu JT, Lee FJ, Chen Y, Lin MI, Chiang FT, Tai TY, Berger SL, Zhao Y, Tsai KS, Zhu H, Chuang LM, Boeke JD. "Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction." Cell. 2011 Sep 16;146(6):969-79. doi: 10.1016/j.cell.2011.07.044. Epub 2011 Sep 9.
Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, Rho HS, Woodard C, Wang H, Jeong JS, Long S, He X, Wade H, Blackshaw S, Qian J, Zhu H. "Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling." Cell. 2009 Oct 30;139(3):610-22. doi: 10.1016/j.cell.2009.08.037.
