Hanghang Wang, M.D., Ph.D.

Headshot of Hanghang Wang
  • Assistant Professor of Surgery

Languages: English, Chinese


Aortic Aneurysms, Aortic Dissections, Aortic Surgery, Aortic Valve Repair, Aortic Valve Sparing Root Replacement, Atrial Fibrillation Surgery, Cardiothoracic Surgery, Coronary Artery Bypass Graft Surgery (CABG), Coronary Artery Disease, General Surgery, Mitral Valve Repair, Mitral Valve Replacement, Mitral Valve Surgery, Thoracic Aortic Aneurysms, Thoracoabdominal Aortic Aneurysm, Tricuspid Valve Repair, Tricuspid Valve Replacement, Tricuspid Valve Surgery ...read more

Research Interests

Precision Medicine; Computational Biology; Bioengineering; Omics; Machine Learning; Artificial Intelligence ...read more

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Main Phone

Outside of Maryland & Washington D.C.

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Suburban Hospital

Appointment Phone: 301-896-7610
8600 Old Georgetown Road
Bethesda, MD 20814 map


Hanghang Wang, M.D., Ph.D. is a Cardiac Surgeon at Suburban Hospital and an Assistant Professor of Surgery at the Johns Hopkins School of Medicine. Dr. Wang received her bachelor’s degree in Biology from Grinnell College, M.D. from Dartmouth Medical School and Ph.D. in Computational Biology & Bioinformatics from Duke University. She also holds a Certificate in College Teaching from Duke University. She completed her general surgery residency at Duke University Medical Center and cardiothoracic surgery fellowship at Johns Hopkins, where she received comprehensive training in mitral valve repair, CABG surgery (both on- and off-pump), and aortic surgery. Further specialized training includes complex mitral and aortic surgeries at the University of Toronto and aortic dissection at one of the world's leading centers for the condition.

Dr. Wang practices all aspects of cardiac surgery, with a special interest in the mitral valve repair surgery. She also has a keen interest in aortic surgery, including aortic dissections.

Dr. Wang leads a translational research lab that intersects cardiac surgery, computational biology, and bioengineering. She has made significant contributions to cardiovascular disease research, discovering novel biomarkers and standardizing metabolomic profiling protocols. She has also played a key role in establishing a comprehensive aortic disease registry and tissue biorepository. Dr. Wang has presented her work at many national and international conferences and has published her work in high-impact journals such as JAMA Cardiology and Circulation.

Her current research projects include:

  • Biomarker Discovery: Aiming to identify novel biomarkers for the rapid diagnosis of acute Type A aortic dissection.
  • Integrative Omics: Utilizing omics approaches for the personalized management of degenerative mitral regurgitation.
  • AI in Surgery: Working on the development of AI-assisted personalized surgical planning for mitral valve repair.
...read more


  • Assistant Professor of Surgery

Departments / Divisions



  • MD; Geisel School of Medicine at Dartmouth (2011)


  • Surgery; Duke University School of Medicine (2013)
  • Surgery; Duke University School of Medicine (2020)
  • Cardiothoracic Surgery; Johns Hopkins University School of Medicine (2023)

Research & Publications


The Cardiovascular Precision Medicine Laboratory led by Dr. Hanghang Wang operates at the intersection of cardiac surgery, computational biology, and bioengineering. With a focus on precision medicine, we are dedicated to creating personalized diagnostic and treatment modalities for cardiovascular diseases, integrating cutting-edge research into clinical practice. Our laboratory is also an integral component of the Broccoli Aortic Center for Aortic Diseases, further enhancing our research capabilities and clinical impact. 

Lab Website: Cardiac Surgery Research Lab

Selected Publications

View all on PubMed

Hahn VS, Petucci C, Kim MS, Bedi KC Jr, Wang H, Mishra S, Koleini N, Yoo EJ, Margulies KB, Arany Z, Kelly DP, Kass DA, Sharma K. Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation. 2023 Apr 11;147(15):1147-1161. doi: 10.1161/CIRCULATIONAHA.122.061846. Epub 2023 Mar 1. PubMed PMID: 36856044.

Wang H, Anstrom K, Ilkayeva O, Muehlbauer MJ, Bain JR, McNulty S, Newgard CB, Kraus WE, Hernandez A, Felker GM, Redfield M, Shah SH. Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial. JAMA Cardiol. 2017 Aug 1;2(8):896-901. doi: 10.1001/jamacardio.2017.1239. PubMed PMID: 28492915; PubMed Central PMCID: PMC5815079

Wang H, Muehlbauer MJ, O'Neal SK, Newgard CB, Hauser ER, Bain JR, Shah SH. Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma. Metabolites. 2017 Aug 25;7(3). doi: 10.3390/metabo7030045. PubMed PMID: 28841195; PubMed Central PMCID: PMC5618330

Wang H, Wagner M, Benrashid E, Keenan J, Wang A, Ranney D, Yerokun B, Gaca JG, McCann RL, Hughes GC. Outcomes of Reoperation After Acute Type A Aortic Dissection: Implications for Index Repair Strategy. J Am Heart Assoc. 2017 Oct 3;6(10). doi: 10.1161/JAHA.117.006376. PubMed PMID: 28974497; PubMed Central PMCID: PMC5721847

Wang H, Hanna JM, Ganapathi A, Keenan JE, Hurwitz LM, Vavalle JP, Kiefer TL, Wang A, Harrison JK, Hughes GC. Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement. Am J Cardiol. 2015 Jun 1;115(11):1568-73. doi: 10.1016/j.amjcard.2015.02.060. Epub 2015 Mar 12. PubMed PMID: 25846765

Activities & Honors


  • AATS Leadership Academy, 2023
  • AATS Foundation Honoring Our Cleveland Clinic Mentors Leadership Program, 2022
  • AATS Foundation Thoracic Surgical Robotics Fellowship, 2021 - 2022
  • AHA FGTB Young Investigator Abstract Travel Award, 2016
  • Thoracic Surgery Foundation for Research and Education Braunwald Fellowship, 2015 - 2017
  • NIH T32 National Research Service Award, NIH, 2015 - 2017
  • Women in Thoracic Surgery (WTS) Scholarship, 2010
  • Summer Fellowship, Memorial Sloan Kettering Cancer Center, 2009
  • AATS Summer Scholarship, 2009
  • Summer Scholar in Thoracic Surgery, Massachusetts General Hospital, 2008
  • Outstanding Commitment to Community Service, Grinnell College, 2007
  • Smith Family Award in Biology, Grinnell College, 2007
  • Joseph F. Wall Scholarship, Grinnell College, 2006
  • High Academic Achievement, Institute for the International Education of Students, 2006
  • Berlin Minority Scholarship, Institute for the International Education of Student, 2006


  • Southern Thoracic Surgical Association, Member, 2021
  • Physician Scientist Training Program Scholars at Johns Hopkins Hospital, 2020
  • Society of Thoracic Surgeons, 2020
  • The Robert J. Lefkowitz Society at Duke Medicine, 2017
  • American Heart Association, 2016
  • Women in Thoracic Surgery, 2011
  • Dartmouth-Mosenthal Surgical Society, 2011
  • Mortar Board National Honor Society, 2007
  • Phi Beta Kappa Honor Society, 2006

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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