Gregory Arthur Newby, Ph.D.

Headshot of Gregory Arthur Newby
  • Assistant Professor of Genetic Medicine

Background

Greg Newby is an Assistant Professor in the McKusick-Nathans Department of Genetic Medicine and jointly affiliated with the Department of Biomedical Engineering.

His research interests include the development of efficient genome editing tools to correct genetic disease mutations as well as studying the regulatory landscape of the genome to better understand and control gene expression.

Dr. Newby earned his bachelor's degree in Biological Sciences from Carnegie Mellon University and conducted research as a Fulbright Scholar in the laboratory of Andreas Plückthun at the University of Zürich. He studied at MIT with Susan Lindquist and Ahmed Khalil for his PhD. From 2017-2023, he was a postdoctoral fellow in the laboratory of David Liu at Harvard University and the Broad Institute. During his postdoctoral work, Dr. Newby developed editing tools and methods to treat disorders of the blood, heart, lung, central nervous system, retina, liver, and skin.

He began his laboratory at JHU in 2023 in order to advance new technology that combats the suffering caused by genetic disease.

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Titles

  • Assistant Professor of Genetic Medicine
  • Assistant Professor of Biomedical Engineering

Departments / Divisions

Education

Degrees

  • B.S.; Carnegie Mellon University (Pennsylvania) (2009)
  • Ph.D.; Massachusetts Institute of Technology (Massachusetts) (2017)

Research & Publications

Lab

Lab Website: Newby Lab

Selected Publications

Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, Sharma A, Henderson JM, Richter MF, Zhao KT, Miller SM, Wang T, Koblan LW, McCaffrey AP, Tisdale JF, Kalfa TA, Pruett-Miller SM, Tsai SQ, Weiss MJ, Liu DR. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature. 2021 Jul;595(7866):295-302. doi: 10.1038/s41586-021-03609-w. Epub 2021 Jun 2. PMID: 34079130; PMCID: PMC8266759

Reichart D*, Newby GA*, Wakimoto H*, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nat Med. 2023 Feb;29(2):412-421. doi: 10.1038/s41591-022-02190-7. Epub 2023 Feb 16. PMID: 36797483; PMCID: PMC9941048. *Co-first authors

Mayuranathan T*, Newby GA*, Feng R, Yao Y, Mayberry KD, Lazzarotto CR, Li Y, Levine RM, Nimmagadda N, Dempsey E, Kang G, Porter SN, Doerfler PA, Zhang J, Jang Y, Chen J, Bell HW, Crossley M, Bhoopalan SV, Sharma A, Tisdale JF, Pruett-Miller SM, Cheng Y, Tsai SQ, Liu DR, Weiss MJ, Yen JS. Potent and uniform fetal hemoglobin induction via base editing. Nat Genet. 2023 Jul;55(7):1210-1220. doi: 10.1038/s41588-023-01434-7. Epub 2023 Jul 3. PMID: 37400614; PMCID: PMC10722557. *Co-first authors

Newby GA, Liu DR. In vivo somatic cell base editing and prime editing. Mol Ther. 2021 Nov 3;29(11):3107-3124. doi: 10.1016/j.ymthe.2021.09.002. Epub 2021 Sep 10. PMID: 34509669; PMCID: PMC8571176

Contact for Research Inquiries

Office/Laboratory
733 N Broadway
Baltimore, MD 21205 map

Email me

Activities & Honors

Honors

  • Pioneer Award, Cystic Fibrosis Foundation, 2023
  • Excellence Award in Collaboration / Support of Science, Broad Institute of MIT and Harvard, 2022

Memberships

  • American Society of Gene and Cell Therapy
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