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Fredrick M Wigley, M.D.

Director, The Johns Hopkins Scleroderma Center
Professor of Medicine

Male

Expertise

Rheumatology, Scleroderma

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Maryland Phone

443-997-1552

Outside of Maryland

410-464-6641

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+1-410-502-7683

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Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 443-997-1552

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map

Phone: 410-550-7715

Background

Dr. Wigley received his M.D. degree from the University of Florida College of Medicine. He completed an internship and residency at Johns Hopkins where he also trained in a postdoctoral fellowship program. Dr. Wigley is a physician-scientist whose specialty is Raynaud’s phenomenon and scleroderma. He founded The Johns Hopkins Scleroderma Center with Robert A. Wise, M.D., of the Johns Hopkins Division of Pulmonary Medicine. Dr. Wigley has been honored with two American College of Rheumatology awards over the past couple years. He received the ACR Distinguished Clinician Scholar Award in 2009 and the ACR Masters Award in 2011.

Titles

Director, The Johns Hopkins Scleroderma Center
Martha McCrory Professor of Medicine
Professor of Medicine

Departments / Divisions

Centers & Institutes

Scleroderma Center

Education

Degrees

MD; Medicine; University of Florida College of Medicine (1972)

Residencies

Medicine; Johns Hopkins University School of Medicine (1975)

Fellowships

Rheumatology; Johns Hopkins University School of Medicine (1979)

Board Certifications

American Board of Internal Medicine (Internal Medicine) (1975)
American Board of Internal Medicine (Rheumatology) (1980)

Research & Publications

Research Summary

Dr. Wigley’s research focuses on the events that cause scleroderma and on the signs and symptoms of scleroderma. He is testing new treatments for Raynaud’s phenomenon and scleroderma.

Clinical Trial Keywords

Raynaud's phenomenon; Scleroderma

Selected Publications

View all on PubMed

Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, Boin F, Fava A, Thoburn C, Kinde I, Jiao Y, Papadopoulos N, Kinzler KW, Vogelstein B, Rosen A. Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer. Science. 2013 Dec 5. [Epub ahead of print] PMID: 24310608
McMahan ZH, Wigley FM. Novel investigational agents for the treatment of scleroderma. Expert Opin Investig Drugs. 2013 Nov 22. [Epub ahead of print] PMID: 24261610
Gerber EE, Gallo EM, Fontana SC, Davis EC, Wigley FM, Huso DL, Dietz HC. Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. Nature. 2013 Nov 7;503(7474):126-30. doi: 10.1038/nature12614. Epub 2013 Oct 9. PMID: 24107997
Tedford RJ, Mudd JO, Girgis RE, Mathai SC, Zaiman AL, Housten-Harris T, Boyce D, Kelemen BW, Bacher AC, Shah AA, Hummers LK, Wigley FM, Russell SD, Saggar R, Saggar R, Maughan WL, Hassoun PM, Kass DA. Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension. Circ Heart Fail. 2013 Sep 1;6(5):953-63. PMID: 23797369
Gelber AC, Manno RL, Shah AA, Woods A, Le EN, Boin F, Hummers LK, Wigley FM. Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature. Medicine (Baltimore). 2013 Jul;92(4):191-205. doi: 10.1097/MD.0b013e31829be125. Review. PMID: 23793108
Matucci-Cerinic M, Kahaleh B, Wigley FM. Review: evidence that systemic sclerosis is a vascular disease. Arthritis Rheum. 2013 Aug;65(8):1953-62. doi: 10.1002/art.37988. Review. No abstract available. PMID: 23666787
Cottrell TR, Wise RA, Wigley FM, Boin F. The degree of skin involvement identifies distinct lung disease outcomes and survival in systemic sclerosis. Ann Rheum Dis. 2013 Apr 20. [Epub ahead of print] PMID: 23606705
Shah AA, Wigley FM. My approach to the treatment of scleroderma. Mayo Clin Proc. 2013 Apr;88(4):377-93. doi: 10.1016/j.mayocp.2013.01.018. Review. PMID: 23541012
Hummers LK, Dugowson CE, Dechow FJ, Wise RA, Gregory J, Michalek J, Yenokyan G, McGready J, Wigley FM. A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon. Ann Rheum Dis. 2013 Dec 1;72(12):1962-7. doi: 10.1136/annrheumdis-2012-201536. Epub 2012 Dec 25. PMID: 23268365
Shah AA, Chung SE, Wigley FM, Wise RA, Hummers LK. Changes in estimated right ventricular systolic pressure predict mortality and pulmonary hypertension in a cohort of scleroderma patients. Ann Rheum Dis. 2013 Jul;72(7):1136-40. doi: 10.1136/annrheumdis-2012-201861. Epub 2012 Aug 11. PMID: 22887850

PubMed

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