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Javier Bolanos Meade, M.D.

Associate Professor of Oncology

Male

Languages: English, Spanish

Expertise

Bone Marrow Transplant, Graft-versus-Host Disease, Hematologic Malignancies, Medical Oncology ...read more

Research Interests

stem cell transplantation; GVHD

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Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map

Phone: 410-614-6398 | Fax: 410-955-1969

Background

As a member of the Johns Hopkins Kimmel Cancer Center, my group's research is focused on finding novel therapies for the treatment of both acute and chronic graft versus host disease (GVHD). To that end, we are developing new strategies for prophylaxis as well as therapies for this problem. We are exploring the use of drugs such as pentostatin in steroid refractory GVHD. This drug inhibits an enzyme, called ADA, that induces apoptosis (cell death) of lymphocytes, the effector cells in GVHD. Our results using this approach have been quite encouraging. Also, we are exploring other novel approaches such as extracorporeal photopheresis or high-dose cyclophosphamide. We are participating in the NIH Bone Marrow Transplant Clinical Trials Network consortium to find useful therapies for GVHD. We are also members of the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials on Chronic GVHD, and there we are trying to establish rational guidelines for supportive care, trial design, etc. We run an internationally unique GVHD multidisciplinary clinic with many GVHD experts including a nurse practitioner, research nurse and others from fields such as physical medicine and rehabilitation, gastroenterology, ophthalmology, dermatology, pulmonology and more.

Titles

Associate Professor of Oncology

Departments / Divisions

Oncology - Hematologic Malignancies

Centers & Institutes

Sidney Kimmel Comprehensive Cancer Center

Education

Degrees

MD; Escuela de Medicina - Ignacio A Santos (1995)

Residencies

Internal Medicine; Texas Tech University Health Sciences Center School of Medicine (1999)

Fellowships

Johns Hopkins University School of Medicine (2003)
Hematology and Oncology; University of Maryland Medical Center (2002)

Research & Publications

Clinical Trial Keywords

GVHD

Selected Publications

Bolanos-Meade, J. Update on the management of acute graft-versus-host disease. Curr Opin Oncol. 2006 Mar;18(2):120-125.

Bolanos-Meade, J.; Hartley, E.; Jones, R.J. Long-term follow-up of allogeneic marrow transplantation for acute myelogenous leukemia after treatment with busulfan and cyclophosphamide. Biol Blood Marrow Transplant. 2006 Mar;12(3):366-367.

Bolanos-Meade, J.; Vogelsang, G.B. Mesenchymal stem cells and organ transplantation: current status and promising future. Transplantation. 2006 May 27;81(10):1388-1389.

Couriel, D.; Carpenter, P.A.; Cutler, C.; Bolanos-Meade, J.; Treister, N.S.; Gea-Banacloche, J.; Shaughnessy, P.; Hymes, S.; Kim, S.; Wayne, A.S.; Chien, J.W.; Neumann, J.; Mitchell, S.; Syrjala, K.; Moravec, C.K.; Abramovitz, L.; Liebermann, J.; Berger, A.; Gerber, L.; Schubert, M.; Filipovich, A.H.; Weisdorf, D.; Schubert, M.M.; Shulman, H.; Schultz, K.; Mittelman, B.; Pavletic, S.; Vogelsang, G.B.; Martin, P.J.; Lee, S.J.; Flowers, M.E. Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol Blood Marrow Transplant. 2006 Apr;12(4):375-396.

Bolanos-Meade, J.; Anders, V.; Wisell, J.; Farmer, E.R.; Vogelsang, G.B. Grover's Disease after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2007 Sep;13(9):1116-1117.

Bolanos-Meade, J.; Garrett-Mayer, E.; Luznik, L.; Anders, V.; Webb, J.; Fuchs, E.J.; Huff, C.A.; Matsui, W.; Borrello, I.M.; Brodsky, R.; Kasamon, Y.L.; Swinnen, L.J.; Flinn, I.W.; Ambinder, R.F.; Jones, R.J.; Hess, A.D.; Vogelsang, G.B. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant. 2007 Oct;13(10):1185-1191.

Bolanos-Meade, J.; Vogelsang, G.B. Montelukast in chronic graft-versus-host disease: a breath of fresh air Transplantation. 2007 Mar 15;83(5):527-528.

Jacobsohn, D.A.; Chen, A.R.; Zahurak, M.; Piantadosi, S.; Anders, V.; Bolanos-Meade, J.; Higman, M.; Margolis, J.; Kaup, M.; Vogelsang, G.B. Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. J Clin Oncol. 2007 Sep 20;25(27):4255-4261.

Loyo, M.; Quintanilla-Dieck Mde, L.; Stein, B.; Bolanos-Meade, J. Bilateral subdural hematoma after hematopoietic stem cell transplantation: a diagnosis often overlooked. Leuk Lymphoma. 2007 Apr;48(4):835-836.

Bolanos-Meade, J.; Vogelsang, G.B. Chronic graft-versus-host disease. Curr Pharm Des. 2008;14(20):1974-1986.

Brodsky, R.A.; Luznik, L.; Bolanos-Meade, J.; Leffell, M.S.; Jones, R.J.; Fuchs, E.J. Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant. 2008 Oct;42(8):523-527.

Luznik, L.; O'Donnell, P.V.; Symons, H.J.; Chen, A.R.; Leffell, M.S.; Zahurak, M.; Gooley, T.A.; Piantadosi, S.; Kaup, M.; Ambinder, R.F.; Huff, C.A.; Matsui, W.; Bolanos-Meade, J.; Borrello, I.; Powell, J.D.; Harrington, E.; Warnock, S.; Flowers, M.; Brodsky, R.A.; Sandmaier, B.M.; Storb, R.F.; Jones, R.J.; Fuchs, E.J. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008 Jun;14(6):641-650.

Alousi, A.M.; Weisdorf, D.J.; Logan, B.R.; Bolanos-Meade, J.; Carter, S.; Difronzo, N.; Pasquini, M.; Goldstein, S.C.; Ho, V.T.; Hayes-Lattin, B.; Wingard, J.R.; Horowitz, M.M.; Levine, J.E. Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network. Blood. 2009 Jul 16;114(3):511-517.

Bolanos-Meade, J.; Brodsky, R.A. Blood and marrow transplantation for sickle cell disease: overcoming barriers to success. Curr Opin Oncol. 2009 Mar;21(2):158-161.

Bolanos-Meade, J.; Luznik, L.; Muth, M.; Matsui, W.H.; Huff, C.A.; Smith, B.D.; Levy, M.Y.; Kasamon, Y.L.; Swinnen, L.J.; Powell, J.D.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant. 2009 Mar;43(6):477-480.

Fuchs, E.J.; Luznik, L.; Bolanos-Meade, J.; Miller, C.B.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J. Successful pregnancy and childbirth after reduced-intensity conditioning and partially HLA-mismatched BMT. Bone Marrow Transplant. 2009 Jun;43(12):969-970.

Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O'Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-Haploidentical BMT with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome. Biol Blood Marrow Transplant. 2009 Nov 16.

Kasamon, Y.L.; Wahl, R.L.; Ziessman, H.A.; Blackford, A.L.; Goodman, S.N.; Fidyk, C.A.; Rogers, K.M.; Bolanos-Meade, J.; Borowitz, M.J.; Ambinder, R.F.; Jones, R.J.; Swinnen, L.J. Phase II study of risk-adapted therapy of newly diagnosed, aggressive non-Hodgkin lymphoma based on midtreatment FDG-PET scanning. Biol Blood Marrow Transplant. 2009 Feb;15(2):242-248.

Bolanos-Meade, J.; Smith, B.D.; Gore, S.D.; McDevitt, M.A.; Luznik, L.; Fuchs, E.J.; Jones, R.J. 5-Azacytidine as Salvage Treatment in Relapsed Myeloid Tumors after Allogeneic Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2010 Oct 15;In Press.

Karp, J.E.; Blackford, A.; Smith, B.D.; Alino, K.; Seung, A.H.; Bolanos-Meade, J.; Greer, J.M.; Carraway, H.E.; Gore, S.D.; Jones, R.J.; Levis, M.J.; McDevitt, M.A.; Doyle, L.A.; Wright, J.J. Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. Leuk Res. 2010 Jul;34(7):877-882.

Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O'Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-489.

Luznik, L.; Bolanos-Meade, J.; Zahurak, M.; Chen, A.R.; Smith, B.D.; Brodsky, R.; Huff, C.A.; Borrello, I.; Matsui, W.; Powell, J.D.; Kasamon, Y.; Goodman, S.N.; Hess, A.; Levitsky, H.I.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-3230.

Bolanos-Meade, J., and Vogelsang, G.B. (2008). Chronic graft-versus-host disease. Curr Pharm Des 14, 1974-1986.

Brodsky, R.A., Luznik, L., Bolanos-Meade, J., Leffell, M.S., Jones, R.J., and Fuchs, E.J. (2008). Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant 42, 523-527.

Luznik, L., O''Donnell, P.V., Symons, H.J., Chen, A.R., Leffell, M.S., Zahurak, M., Gooley, T.A., Piantadosi, S., Kaup, M., Ambinder, R.F., Huff, C.A., Matsui, W., Bolanos-Meade, J., Borrello, I., Powell, J.D., Harrington, E., Warnock, S., Flowers, M., Brodsky, R.A., Sandmaier, B.M., Storb, R.F., Jones, R.J., and Fuchs, E.J. (2008). HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 14, 641-650.

Bolanos-Meade, J., and G. B. Vogelsang. 2007. Montelukast in chronic graft-versus-host disease: a breath of fresh air? Transplantation 83:527-8.

Bolanos-Meade, J., E. Garrett-Mayer, L. Luznik, V. Anders, J. Webb, E. J. Fuchs, C. A. Huff, W. Matsui, I. M. Borrello, R. Brodsky, Y. L. Kasamon, L. J. Swinnen, I. W. Flinn, R. F. Ambinder, R. J. Jones, A. D. Hess, and G. B. Vogelsang. 2007. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant 13:1185-91.

Bolanos-Meade, J., V. Anders, J. Wisell, E. R. Farmer, and G. B. Vogelsang. 2007. Grover''s Disease after Bone Marrow Transplantation. Biol Blood Marrow Transplant 13:1116-7.

Jacobsohn, D. A., A. R. Chen, M. Zahurak, S. Piantadosi, V. Anders, J. Bolanos-Meade, M. Higman, J. Margolis, M. Kaup, and G. B. Vogelsang. 2007. Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. J Clin Oncol 25:4255-61.

Loyo, M., L. Quintanilla-Dieck Mde, B. Stein, and J. Bolanos-Meade. 2007. Bilateral subdural hematoma after hematopoietic stem cell transplantation: a diagnosis often overlooked. Leuk Lymphoma 48:835-6.

Bolanos-Meade, J. & Vogelsang, G. B. (2006). Mesenchymal stem cells and organ transplantation: current status and promising future. Transplantation 81, 1388-9.

Bolanos-Meade, J. (2006). Update on the management of acute graft-versus-host disease. Curr Opin Oncol 18, 120-5.

Bolanos-Meade, J., Hartley, E. & Jones, R. J. (2006). Long-term follow-up of allogeneic marrow transplantation for acute myelogenous leukemia after treatment with busulfan and cyclophosphamide. Biol Blood Marrow Transplant 12, 366-7.

Couriel, D., Carpenter, P. A., Cutler, C., Bolanos-Meade, J., Treister, N. S., Gea-Banacloche, J., Shaughnessy, P., Hymes, S., Kim, S., Wayne, A. S., Chien, J. W., Neumann, J., Mitchell, S., Syrjala, K., Moravec, C. K., Abramovitz, L., Liebermann, J., Berger, A., Gerber, L., Schubert, M., Filipovich, A. H., Weisdorf, D., Schubert, M. M., Shulman, H., Schultz, K., Mittelman, B., Pavletic, S., Vogelsang, G. B., Martin, P. J., Lee, S. J. & Flowers, M. E. (2006).

Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol Blood Marrow Transplant 12, 375-96.

Bolaos-Meade, J., Zhou, L., Hoke, A., Corse, A., Vogelsang, G.,Wagner, K. R. In press. Hydroxychloroquine causes a severe vacuolar myopathy in a patient with chronic graft-versus-host disease. Am J Hematol.

Bolaos-Meade, J., Ioffe, O., Hey, J., Vogelsang, G. B., Akpek, G. In press. Lymphocytic pneumonitis as the manifestation of acute graft-versus-host disease of the lung. Am J Hematol.

Bolaos-Meade, J., Jacobsohn, D. A., Margolis, J., Ogden, A., Wientjes, M. G., Byrd, J. C., Lucas, D. M., Anders, V., Phelps, M., Grever, M. R., Vogelsang, G. B. In press. Pentostatin in steroid refractory acute graft-versus-host disease. J Clin Oncol.

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