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David Lee Thomas, M.D., M.P.H.

Headshot of David Lee Thomas
  • Director, Division of Infectious Diseases
  • Professor of Medicine


Hepatitis B (HBV), Hepatitis C (HCV), Infectious Disease, Infectious Diseases more

Research Interests

Hepatitis C, Hepatitis B, and HIV


The John G. Bartlett Specialty Practice

1717 E. Monument Street
Baltimore, MD 21287 map
Phone: 443-997-1900 | Fax: 443-287-4173


Dr. David Lee Thomas is a professor of medicine at the Johns Hopkins University School of Medicine. He is trained in internal medicine and infectious diseases and cares for patients with chronic viral hepatitis. 

Dr. Thomas serves as the director of the Division of Infectious Diseases and is the Stanhope Bayne-Jones Professor of Medicine. He is also co-director of the Center for AIDS Research Clinical Core.

He earned his undergraduate degree in chemistry, in 1982, and his medical degree, in 1986, from West Virginia University. He then completed his medical training and residency at Wake Forest University in North Carolina, before coming to Johns Hopkins as a research fellow in infectious diseases. He went on to earn his Master of Public Health at the Johns Hopkins Bloomberg School of Public Health. He joined the faculty at both schools, the School of Medicine in 1993 and Public Health in 1994. 

From 2005 to 2006, he served as director of research at the Infectious Diseases Institute in Kampala, Uganda. The institute provides free medical and social services for HIV-1-infected Ugandans and training for physicians and nurses from across sub-Saharan Africa.

For his commitment to translating medical research into advances in the care of people living with both hepatitis C and HIV, the American Society of Clinical Investigation named Dr. Thomas to its honor list of physician-scientists in 2001. more


  • Director, Division of Infectious Diseases
  • Stanhope Bayne-Jones Professor of Medicine
  • Co-Director, Clinical Core, Johns Hopkins Center for AIDS Research
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; West Virginia University School of Medicine (1986)


  • Internal Medicine; Wake Forest University School of Medicine (1990)


  • Infectious Diseases; Johns Hopkins University School of Medicine (1993)

Board Certifications

  • American Board of Internal Medicine (Infectious Disease) (1992)
  • American Board of Internal Medicine (Internal Medicine) (1989)

Research & Publications

Research Summary

Dr. Thomas oversees clinical research projects whose aims are focused on understanding the natural history and pathogenesis of hepatitis C virus infection. Liver disease in HIV infected people is a special area of clinical and research focus. He is the principal investigator on numerous National Institutes of Health grants and holds a U.S. patent.

Selected Publications

View all on PubMed

Balagopal, Ashwin; David M. Asmuth; Wei-Teng Yang; Thomas B. Campbell; Nikhil Gupte; Laura Smeaton; Cecilia Kanyama; Beatriz Grinsztejn; Breno Santos; Khuanchai Supparatpinyo; et al. “Pre-cART elevation of CRP and CD4<sup>+</sup> t-cell immune activation associated with HIV clinical progression in a multinational case-cohort study.” Journal of Acquired Immune Deficiency Syndromes. 2015;70(2):163-171. 0

Bailey, Justin R.; Kimberly A. Dowd; Anna E. Snider; William O. Osburn; Shruti H. Mehta; Gregory D. Kirk; David L. Thomas; Stuart C. Ray. “CD4 <sup>+</sup> T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus.” Journal of Infectious Diseases. 2015;212(6):914-923. 1

Chung, Raymond T.; Gary L. Davis; Donald M. Jensen; Henry Masur; Michael S. Saag; David L. Thomas; Andrew I. Aronsohn; Michael R. Charlton; Jordan J. Feld; Robert J. Fontana; et al. “Hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus.” Hepatology. 2015;62(3):932-954.

Hiramine, Satoshi; Masaya Sugiyama; Norihiro Furusyo; Hirofumi Uto; Akio Ido; Hirohito Tsubouchi; Hisayoshi Watanabe; Yoshiyuki Ueno; Masaaki Korenaga; Kazumoto Murata; et al. “A thymine–adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus.” Journal of Gastroenterology. 2015.

El-Diwany, Ramy; Lisa N. Wasilewski; Kenneth W. Witwer; Justin R. Bailey; Kimberly Page; Stuart C. Ray; Andrea L. Cox; David L. Thomas; Ashwin Balagopal. “Acute hepatitis C virus infection induces consistent changes in circulating MicroRNAs that are associated with nonlytic hepatocyte release.” Journal of Virology. 2015;89(18):9454-9464.

Activities & Honors


  • MERIT (Method to Extend Research in Time) Award, National Institute on Drug Abuse, 2010
  • Honor List of Physician-Scientists, American Society of Clinical Investigation, 2001
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