Dr. Needham has over 350 publications, with his research focused on advancing medical care in the intensive care unit to improve patients’ long-term outcomes (LTO), including physical, psychological, and quality of life status after critical illness (details at: https://www.hopkinsmedicine.org/pulmonary/research/outcomes-after-critical-illness/). He is focused on innovative research aimed at improving methods of physical rehabilitation to reduce muscle weakness and functional impairment, as well as preventing and treating delirium in the intensive care unit (see https://www.johnshopkinssolutions.com/solution/amp/activity-mobility-promotion-amp-icu/). His research interests also include patient safety, quality of care, and “knowledge translation” of evidence-based therapies into clinical practice. He is a Principal Investigator on many federally-funded, peer-reviewed grants, including the NIH-funded ARDSNet Long-Term Outcomes Study (ALTOS), the Improving Care of Acute Lung Injury Patients (ICAP) study, and the ImproveLTO national infrastructure grant aimed at advancing clinical research methodology for improving acute respiratory failure patients’ outcomes after hospital discharge.
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Ruhl AP, Huang M, Colantuoni E, Karmarkar T, Dinglas VD, Hopkins RO, Needham DM; With the National Institutes of Health, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Healthcare utilization and costs in ARDS survivors: a 1-year longitudinal national US multicenter study. Intensive Care Med. 2017 May 26. doi: 10.1007/s00134-017-4827-8. [Epub ahead of print]
Turnbull AE, Hashem MD, Rabiee A, To A, Chessare CM, Needham DM. Evaluation of a strategy for enrolling the families of critically ill patients in research using limited human resources. PLoS One. 2017 May 25;12(5):e0177741. doi: 10.1371/journal.pone.0177741. eCollection 2017.
Needham DM, Sepulveda KA, Dinglas VD, Chessare CM, Aronson Friedman L, Bingham Iii CO, Turnbull AE. Core Outcome Measures for Clinical Research in Acute Respiratory Failure Survivors: An International Modified Delphi Consensus Study. Am J Respir Crit Care Med. 2017 May 24. doi: 10.1164/rccm.201702-0372OC. [Epub ahead of print]
Alugubelli NR, Al-Ani A, Needham DM, Parker AM. Understanding early goal-directed mobilization in the surgical intensive care unit. Ann Transl Med. 2017 Apr;5(7):176. doi: 10.21037/atm.2017.03.44.
Hopkins RO, Suchyta MR, Kamdar BB, Darowski E, Jackson JC, Needham DM. Instrumental Activities of Daily Living after Critical Illness: A Systematic Review. Ann Am Thorac Soc. 2017 May 2. doi: 10.1513/AnnalsATS.201701-059SR. [Epub ahead of print]