Dr. Thio has several research interests. Her laboratory is focused on hepatitis B translational science that is working towards a hepatitis B cure including HBV virology in single hepatocytes, immune response to acute hepatitis B, and neutralizing antibodies to hepatitis B.
Her laboratory also investigates the human genetic determinants of HBV and HCV clearance, where she examines polymorphisms in human genes in persons that have either recovered from or have a persistent viral hepatitis infection.
Her laboratory also studies fatty liver in people with HIV and HIV-hepatitis co-infection.
Learn more about clinical trials at Johns Hopkins Medicine.
Thio CL, Guo N, Xie C, Nelson KE, Ehrhardt S. “Global elimination of mother-to-child transmission of hepatitis B: Revisiting the current strategy.” The Lancet Infectious Diseases. 2015;15(8):981-985.
Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Phair P, Witt WD, Thio CL. Incident hepatitis B in HIV-infected and HIV-uninfected men who have sex with men from pre-HAART to HAART periods: a cohort study. Ann Int Med; 2015 Nov; 163(9):673-80. PMCID PMC4630157
Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P. Multi-ancestry genome-wide association study of spontaneous clearance of hepatitis C virus. Gastroenterology 2018 Dec, in press
Li Y, Xie J, Wang H, Han Y, Wang N, Li T*, Thio CL* (contributed equally). Elevated pre-treatment IL-18 level is associated with HBeAg seroconversion in HIV-HBV co-infection. Antiviral Therapy, 2017; 22(6):523-27
Price JC, Seaberg EC, Stosor V, Witt MD, Lellock CD, Thio CL. AST-to-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis coinfected men. AIDS 2018 Nov 32(17):2636-38.