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Chloe Lynne Thio, M.D.

Headshot of Chloe Lynne Thio
  • Professor of Medicine

Specializes in: Adults (18+ years)



Hepatitis, HIV/AIDS, Infectious Disease

Research Interests

Hepatitis B, hepatitis C, HIV

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The Johns Hopkins Hospital

Appointment Phone: 443-997-1900
600 N. Wolfe Street
Carnegie 346
Baltimore, MD 21287 map
Phone: 410-955-1725


Dr. Chloe Thio is a professor of medicine and an associate professor of molecular microbiology and immunology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include hepatitis, HIV/AIDS and infectious disease. 

Dr. Thio received her B.A. from the University of Pennsylvania. She earned her M.D. from the Yale University School of Medicine. She completed her residency at Hospital of the University of Pennsylvania and performed a fellowship in infectious diseases at Johns Hopkins. 

Her research interests include hepatitis and HIV/AIDS. Her recent research revealed that certain HIV drugs provide added benefit of protecting against hepatitis B. 

Dr. Thio serves on the Promotions Committee for the Department of Medicine. She is a member of the American College of Physicians, the American Association for the Study of Liver Disease, the American Society of Clinical Investigation, HIVMA and the Infectious Diseases Society of America. more


  • Professor of Medicine

Departments / Divisions

Centers & Institutes

  • Infectious Disease Center for Viral Hepatitis
  • Infectious Diseases Center for Viral Hepatitis Research



  • MD; Yale School of Medicine (1992)


  • Internal Medicine; Hospital of the University of Pennsylvania (1995)


  • Infectious Diseases; Johns Hopkins University School of Medicine (2000)

Board Certifications

  • American Board of Internal Medicine (Infectious Disease) (1998)

Research & Publications

Research Summary

Dr. Thio has several research interests. Her laboratory is focused on hepatitis B translational science that is working towards a hepatitis B cure including HBV virology in single hepatocytes, immune response to acute hepatitis B, and neutralizing antibodies to hepatitis B.

Her laboratory also investigates the human genetic determinants of HBV and HCV clearance, where she examines polymorphisms in human genes in persons that have either recovered from or have a persistent viral hepatitis infection.

Her laboratory also studies fatty liver in people with HIV and HIV-hepatitis co-infection.

Selected Publications

Thio CL, Guo N, Xie C, Nelson KE, Ehrhardt S. “Global elimination of mother-to-child transmission of hepatitis B: Revisiting the current strategy.” The Lancet Infectious Diseases. 2015;15(8):981-985.

Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Phair P, Witt WD, Thio CL. Incident hepatitis B in HIV-infected and HIV-uninfected men who have sex with men from pre-HAART to HAART periods: a cohort study. Ann Int Med; 2015 Nov; 163(9):673-80. PMCID PMC4630157

Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P. Multi-ancestry genome-wide association study of spontaneous clearance of hepatitis C virus. Gastroenterology 2018 Dec, in press

Li Y, Xie J, Wang H, Han Y, Wang N, Li T*, Thio CL* (contributed equally). Elevated pre-treatment IL-18 level is associated with HBeAg seroconversion in HIV-HBV co-infection. Antiviral Therapy, 2017; 22(6):523-27

Price JC, Seaberg EC, Stosor V, Witt MD, Lellock CD, Thio CL.  AST-to-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis coinfected men. AIDS 2018 Nov 32(17):2636-38.

Contact for Research Inquiries

855 N Wolfe Street
Room 533
Baltimore, MD 21205 map
Phone: 410-614-6088

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Academic Affiliations & Courses

Graduate Program Affiliation

Molecular Microbiology and Immunology

Activities & Honors


  • American College of Physicians
  • American Society of Clinical Investigation
  • Infectious Diseases Society of America
  • American Association for the Study of Liver Disease

Professional Activities

  • Promotions Committee, Johns Hopkins Department of Medicine, 2015
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