Chloe Lynne Thio, M.D.

Headshot of Chloe Lynne Thio
  • Professor of Medicine

Specializes in: Adults (18+ years)



Hepatitis, HIV/AIDS, Infectious Disease

Research Interests

Hepatitis B, hepatitis C, HIV

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Main Phone

Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital

Appointment Phone: 443-997-1900
600 N. Wolfe Street
Carnegie 346
Baltimore, MD 21287
Phone: 410-955-1725
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Dr. Chloe Thio is a professor of medicine and an associate professor of molecular microbiology and immunology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include hepatitis, HIV/AIDS and infectious disease. 

Dr. Thio received her B.A. from the University of Pennsylvania. She earned her M.D. from the Yale University School of Medicine. She completed her residency at Hospital of the University of Pennsylvania and her fellowship in infectious diseases at Johns Hopkins. 

Her research interests include chronic hepatitis B and  C and coinfection of viral hepatitis with HIV/AIDS. She has developed a program centered around virology and immunology translational work towards an HBV cure.  

Dr. Thio is a member of the American College of Physicians, the American Association for the Study of Liver Disease, the American Society of Clinical Investigation, HIVMA and the Infectious Diseases Society of America. more


  • Professor of Medicine

Departments / Divisions

Centers & Institutes

  • Infectious Disease Center for Viral Hepatitis
  • Infectious Diseases Center for Viral Hepatitis Research



  • MD; Yale School of Medicine (1992)


  • Internal Medicine; Hospital of the University of Pennsylvania (1995)


  • Infectious Diseases; Johns Hopkins University School of Medicine (2000)

Board Certifications

  • American Board of Internal Medicine (Infectious Disease) (1998)

Research & Publications

Research Summary

Dr. Thio has several research interests. Her laboratory is focused on hepatitis B translational science that is working towards a hepatitis B cure including HBV virology in single hepatocytes, immune response to acute hepatitis B, and neutralizing antibodies to hepatitis B.

Her laboratory also investigates the human genetic determinants of HBV and HCV clearance, where she examines polymorphisms in human genes in persons that have either recovered from or have a persistent viral hepatitis infection.

Her laboratory also studies fatty liver in people with HIV and HIV-hepatitis co-infection.

Selected Publications

Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Wolinsky SM, Witt MD, Thio CL. Outcomes of acute hepatitis B virus (HBV) in HIV infection with and without HBV-active antiretroviral therapy. AIDS 2021 May; 35(6): 991-993

Irvin R, Gamble T, Malone J, Wang Z, Wilson E, Hughes JP, Farley J, Mayer KH, Del Rio C, Batey DS, Cummings V, Remien RH, Beyrer C, Thio CL. HTPN 078: High prevalence of HCV antibodies among urban US men who have sex with men (MSM) independent of HIV status. CID, 2021 Oct 73(7):e2205-2210

Balagopal A, Grudda T, Ribeiro RM, Saad YS, Hwang HS, Quinn J, Murphy M, Ward K, Sterling RK, Zhang Y, Perelson AS, Sulkowski MS, Osburn WO, Thio CL. Single hepatocytes show persistence and transcriptional inactivity of hepatitis B. JCI Insight 2020 Oct 5(19): 140584

Price JC, Wang R, Seaberg EC, Brown TT, Budoff MJ, Kingley LA, Palella, FJ, Witt MD, Post WS, Lake JE, Thio CL. Sex hormone binding globulin levels are inversely associated with nonalcoholic fatty liver disease in HIV-infected and –uninfected men. OFID 2019 December,:6(12):ofz468. PMC7047947

Stevens KE, Thio CL, Osburn WO. CCR5 deficiency enhances hepatic innate immune cell recruitment & inflammation in a murine model of acute hepatitis B infection. Immun Cell Biol 2019 Mar, 97(3):317-25

Contact for Research Inquiries

855 N Wolfe Street
Room 533
Baltimore, MD 21205 map
Phone: 410-614-6088

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Academic Affiliations & Courses

Graduate Program Affiliation

Molecular Microbiology and Immunology


Activities & Honors


  • American College of Physicians
  • American Society of Clinical Investigation
  • Infectious Diseases Society of America
  • American Association for the Study of Liver Disease

Professional Activities

  • Promotions Committee, Johns Hopkins Department of Medicine, 2015 - 2020
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