Chiadi Onyike, M.B.B.S., M.D.

Chiadikaobi Uchendu Onyike, M.B.B.S., M.D.

Headshot of Chiadi Onyike
  • Director, Frontotemporal Dementias Program
  • Associate Professor of Psychiatry and Behavioral Sciences

Languages: English, Igbo


Adult Psychiatry, Alzheimer's Disease (AD), Behavioral Disorders in Dementia, Behavioral Medicine, Cognitive Disorders, Creutzfeldt-Jakob Disease, Dementia, Disorders of Executive Function, Disorders of Social Cognition, Frontotemporal Dementias, Geriatric Psychiatry, Neuropsychiatry, Primary Aphasias, Prion Diseases, Psychiatry, Psychiatry and Behavioral Sciences, Young-Onset Dementias more

Research Interests

Phenomenology; neuropsychiatry; neuropathology; epidemiology; measurement and management of neurodegenerative disorders (including frontotemporal dementias, young-onset Alzheimer disease, Lewy body disease and other parkinsonian dementias, cerebrovascular dementias, prion disease, leukodystrophies); treatment development and clinical trials for neurodegenerative disease more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-5147
600 N. Wolfe Street
Meyer Building, Suite 235
Baltimore, MD 21287
Phone: 410-955-5147 | Fax: 410-502-4133
The Johns Hopkins Hospital - Google Maps


Dr. Onyike is a specialist in neuropsychiatry. He focuses on the diagnosis and care of neurodegenerative diseases that develop in midlife or earlier. These include frontotemporal dementias, young-onset Alzheimer diseases, prion diseases, leukodystrophy and other atypical conditions that cause cognitive and behavioral impairments and dementia. He is also engaged in research focused on the epidemiology and treatment of frontotemporal dementias, Alzheimer disease, Lewy body disease, spinocerebellar ataxias, and other neurodegenerative disorders.

Dr. Onyike has advised national and international research agencies, and philanthropic organizations, including the NIH, FDA, MRC-UK, and others. He serves on the Medical Advisory Council of the Association for Frontotemporal Degeneration, and the Scientific Advisory Boards of the FTD Disorders Registry and the Tau Consortium. He serves on the Alzheimer’s Association Best Clinical Practices Guidelines Work Group, and has participated in NIA/NINDS Alzheimer’s Disease and Related Dementias workshop committees. He is a founding member of the International Society for Frontotemporal Dementias, and a member of the Executive Committee. more


  • Director, Frontotemporal Dementias Program
  • Director, Young-Onset Dementias Program
  • Associate Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Centers & Institutes



  • MD; College of Medicine (1991)


  • Psychiatry; Johns Hopkins University School of Medicine (2000)


  • Johns Hopkins University School of Medicine (2002)

Research & Publications

Clinical Trial Keywords

Alzheimer's; frontotemporal dementia; clinical trial

Selected Publications

View all on PubMed

Kamath V, Chaney GS, DeRight J, Onyike CU. A meta-analysis of neuropsychological, social cognitive, and olfactory functioning in the behavioral and language variants of frontotemporal dementia. Psychol Med. 2018 Dec 6;:1-12. doi: 10.1017/S0033291718003604. PubMed PMID: 30520407

Tsapkini K, Webster KT, Ficek BN, Desmond JE, Onyike CU, Rapp B, Frangakis CE, Hillis AE. Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial. Alzheimers Dement (N Y). 2018;4:461-472. doi: 10.1016/j.trci.2018.08.002. eCollection 2018. PubMed PMID: 30258975; PubMed Central PMCID: PMC6153381

Morrow CB, Leoutsakos J-MS, Onyike CU. Functional disabilities and psychiatric symptoms in primary progressive aphasia. Am J Geriatr Psychiatry 2022, 30(3):372-382.. PubMed PMID: 28059789; PubMed Central PMCID: PMC5652315

Kansal K, Yang Z, Fishman AM, Sair HI, Ying SH, Jedynak BM, Prince JL, Onyike CU. Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration. Brain. 2017 Mar 1;140(3):707-720. doi: 10.1093/brain/aww327. PubMed PMID: 28043955; PubMed Central PMCID: PMC5837314

Kansal K, Mareddy M, Sloane KL, Minc AA, Rabins PV, McGready JB, Onyike CU. Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis. Dement Geriatr Cogn Disord. 2016;41(1-2):109-22. doi: 10.1159/000443205. Epub 2016 Feb 9. Review. PubMed PMID: 26854827

Activities & Honors


  • Board of Directors, Alzheimers Association of Greater Maryland
  • Medical and Scientific Advisory Board, Alzheimers Association of Greater Maryland
  • World Federation of Neurology Research Group on Aphasia and Cognitive Disorders
  • Medical Advisory Committee, Association for Frontotemporal Degeneration
  • Finance Committee, International Society for Frontotemporal Dementias
  • Peripheral and Central Nervous Systems Drugs Advisory Committee, US Food and Drug Administration


  • American Association for Geriatric Psychiatry
  • American Neuropsychiatric Association
  • American Psychiatric Association
  • International Psychogeriatric Society
  • International Society for Frontotemporal Dementias
  • International Society to Advance Alzheimer Research and Treatment (ISTAART)
  • Maryland Psychiatric Society
  • Society for Behavioral and Cognitive Neurology
  • Association of Nigerian Physicians in the Americas
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