Carlo Colantuoni, Ph.D.
Dr. Colantuoni is an assistant professor in the departments of Neurology and Neuroscience. He earned his A.B. from Princeton University in 1996 and his Ph.D. from Johns Hopkins School of Medicine in 2002. Dr. Colantuoni and his colleagues elucidate fundamental mechanisms in human brain development that impact risk for complex brain disease using human brain tissue and human pluripotent cell resources.
To elucidate fundamental mechanisms in human brain development, I leverage diverse multi-omic data resources from postmortem human brain tissue, animal models, and human pluripotent stem cell systems.
Defining common transcriptional elements across these systems will enable us to develop meaningful, mechanistic connections between the in vivo observations and the in vitro experimental systems.
The eventual goal is to design experiments in the precisely controlled in vitro differentiation systems which will, in effect, allow us to probe the in vivo systems of human brain development and elucidate mechanisms of risk for complex brain disease.
Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory. Haberman RP, Colantuoni C, Koh MT, Gallagher M. PLoS One. 2013 Dec 13;8(12):e83674. doi: 10.1371/journal.pone.0083674. eCollection 2013. PMID: 24349543
Pattern identification in time-course gene expression data with the CoGAPS matrix factorization. Fertig EJ, Stein-O'Brien G, Jaffe A, Colantuoni C. Methods Mol Biol. 2014;1101:87-112. doi: 10.1007/978-1-62703-721-1_6. PMID: 24233779
DNA methylation signatures in development and aging of the human prefrontal cortex. Numata S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, Colantuoni C, Weinberger DR, Kleinman JE, Lipska BK. Am J Hum Genet. 2012 Feb 10;90(2):260-72. doi: 10.1016/j.ajhg.2011.12.020. Epub 2012 Feb 2. Erratum in: Am J Hum Genet. 2012 Oct 5;91(4):765. PMID: 22305529
Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Colantuoni C, Lipska BK, Ye T, Hyde TM, Tao R, Leek JT, Colantuoni EA, Elkahloun AG, Herman MM, Weinberger DR, Kleinman JE. Nature. 2011 Oct 26;478(7370):519-23. doi: 10.1038/nature10524. PubMed PMID: 22031444