Argye Hillis, M.D.

Argye Elizabeth Hillis, M.D.

Headshot of Argye Hillis
  • Director, Center of Excellence in Stroke Detection and Diagnosis, Sheikh Khalifa Stroke Institute
  • Professor of Neurology


Aphasia, Apraxia, Cortical Visual and Perceptual Impairments, Corticobasal Degeneration, Dementia, Neurology, Speech and Language Impairments, Stroke more

Research Interests

Stroke Cognitive Outcome and Recovery (SCORE); Language Recovery After Stroke; Cognitive Deficits and Recovery after Right Hemisphere Stroke more

Request an Appointment

Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

Request Appointment

International Patients

Request Appointment


The Johns Hopkins Hospital

Appointment Phone: 410-955-2228
600 N. Wolfe Street
Phipps Suite 446
Baltimore, MD 21287 map
Fax: 410-614-9807

Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 410-955-2228
601 N. Caroline St.
Baltimore, MD 21287 map
Fax: 410-614-9807

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-955-2228
10753 Falls Road
Neurosciences Consultation and Infusion Center, Pavilion II, Suite 115
Lutherville, MD 21093 map
Fax: 410-614-9807


Dr. Argye Hillis is a professor of Neurology, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science. She is also the Sheikh Khalifa Stroke Institute Professor of Acute Stroke Diagnoses and Management.

Prior to medical training and neurology residency, Dr. Hillis worked as a speech-language pathologist, and conducted clinical research focusing on understanding and treating aphasia and hemispatial neglect. She has brought these areas of experience to impact on her clinical research in neurology, which involves cognitive and neuroimaging studies of aphasia and hemispatial neglect due to acute stroke and focal dementias. She has published extensively on these topics in journals and textbooks.

Dr. Hillis is Associate Editor of Stroke and has served as Associate editor of Brain, Annals of Neurology, Aphasiology, American Journal of Speech-Language Pathology, Neurocase, Cognitive Neuropsychology, and Language and Cognitive Processes and served as co-Editor and Chief of Behavioral Neurology.

Dr. Hillis serves as the Executive Vice Chair of the Department of Neurology and the Director of the Cerebrovascular Division of Neurology at Johns Hopkins. more


  • Director, Center of Excellence in Stroke Detection and Diagnosis, Sheikh Khalifa Stroke Institute
  • Sheikh Khalifa Stroke Institute Professor of Acute Stroke Diagnoses and Management
  • Director, Cerebrovascular Division of Neurology
  • Executive Vice Chair, Department of Neurology
  • Professor of Neurology
  • Professor of Physical Medicine and Rehabilitation

Departments / Divisions

Centers & Institutes



  • MD; Medicine; Johns Hopkins University School of Medicine (1995)


  • Neurology; Johns Hopkins University School of Medicine (1999)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2001)

Research & Publications

Research Summary

Following a stroke, an individual may experience speech, language, cognitive, or emotional problems. Dr. Hillis’ current research aims to improve the understanding of how language and other cognitive functions are represented and carried out in the brain, how they recover after injury, and how understanding these processes can contribute to evaluation and treatment of stroke and dementia. Specifically, current research studies include the following:

  • Stroke Cognitive Outcome and Recovery (SCORE)
  • Language Recovery After Stroke
  • Cognitive Deficits and Recovery after Right Hemisphere Stroke

Dr. Hillis' current research combines longitudinal task-related and task-free functional imaging and structural imaging from the acute stage of stroke through the first year of recovery, with detailed cognitive and language assessments to improve our understanding how language and other cognitive functions recover after stroke. Her other avenue of research involves novel treatment studies and longitudinal imaging and language studies of Primary Progressive Aphasia. She has published extensively on these topics in journals and textbooks.

Selected Publications

View all on PubMed


Hillis, A.E. (1989). Efficacy and generalization of treatment for aphasic naming errors. Archives of Physical Medicine and Rehabilitation, 70, 632-636.

Caramazza, A. & Hillis, A.E. (1991). Lexical organization of nouns and verbs in the brain. Nature, 349,788-90.

Hillis, A.E. & Caramazza, A. (1991). Category-specific naming and comprehension impairment: A double dissociation. Brain, 114, 2081-2094.

Hillis, A.E. & Caramazza, A. (1995). Cognitive and neural mechanisms underlying visual and semantic processing. Journal of Cognitive Neuroscience, 7, 457-478.

Hillis, A.E. & Caramazza, A. (1995). The representation of grammatical categories of words in the brain. Journal of Cognitive Neuroscience, 7, 396-407.

Hillis, A.E., Boatman, D., Hart, J. & Gordon, B. (1999). Making sense out of jargon: a neurolinguistic and computational account of jargon aphasia. Neurology, 53, 1813-1824.

Hillis, A.E., Wityk, R.J., Tuffiash, E., Beauchamp, N.J., Jacobs, M.A., Barker, P.B., Selnes, O.A. (2001). Hypoperfusion of Wernickes area predicts severity of semantic deficit in acute stroke. Annals of Neurology, 50, 561-566.

Hillis, A.E., Wityk, R.J., Barker, P.B., Beauchamp, N.J., Gailloud, P., Murphy, K., Cooper, O., Metter, E.J. (2002). Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion, Brain,125, 1094-1104.

Hillis, A.E., Tuffiash, E. & Caramazza, A. (2002). Modality specific deterioration in oral naming of verbs. Journal of Cognitive Neuroscience, 14, 1099-1108.

Hillis, A.E., Wityk, R., Barker, P.B., Caramazza, A. (2003). Neural regions essential for writing verbs. Nature Neuroscience, 6, 19-20.

Hillis, A.E., Oh, S., Ken, L. (2004). Deterioration of naming nouns versus verbs in primary progressive aphasia. Annals of Neurology, 55, 268-275.

Hillis, A.E., Work, M., Breese, E.L., Barker, P.B., Jacobs, M.A. & Maurer, K. (2004). Re-examining the brain regions crucial for orchestrating speech articulation. Brain, 127, 1479-1487.

Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Herskovits, E., and Degaonkar, M. (2005). The roles of the visual word form area in reading. NeuroImage, 24, 548-559.

Reineck, L., Agarwal, S. & Hillis, A.E. (2005). The diffusion-clinical mismatch predicts early language recovery in acute stroke. Neurology, 64, 828-833.

Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Degaonkar, M. (2005). Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. Journal of Neuroscience, 25, 3161-7.

Charles, R. & Hillis, A.E. (2005). Posterior Cortical Atrophy: clinical presentation and cognitive deficits compared to Alzheimers Disease. Behavioural Neurology, 16, 15-23.

Hillis, A.E., Heidler-Gary, J., Newhart, M., Chang, S., Ken, L. & Bak, T. (2006). Naming and comprehension in primary progressive aphasia: the influence of grammatical word class. Aphasiology, 20, 246-256.

Newhart, M., Ken, L., Kleinman, J.T., Heidler-Gary, J., & Hillis, A.E. (2007). Neural networks essential for naming and word comprehension. Cognitive and Behavioral Neurology, 20, 25-30.

DeLeon, J., Gottesman, R.F., Kleinman, J.T., Newhart, M., Davis, C., Lee, A., Hillis, A.E. (2007) Neural regions essential for distinct cognitive processes underlying picture naming. Brain, 130, 1408-22.

Heidler-Gary, J. & Hillis, A.E. (2007). Distinctions between the dementia in Amyotrophic Lateral Sclerosis with Frontotemporal Dementia and the dementia of Alzheimer''s Disease. Amyotrophic Lateral Sclerosis.

Philipose, L.E., Gottesman, R.F., Newhart, M.; Kleinman, J.T.; Herskovits, E.H.; Pawlak, M.A., Marsh, E.B.; Davis, C.; Heidler-Gary, J.; Hillis, A.E. (2008). Neural regions essential for reading and spelling of words and pseudowords. Annals of Neurology. 481-492.

Cloutman, L., Gottesman, R., Chaudhry, P., Davis, C., Kleinman, J.T., Pawlak, M., Herskovits, E.H., Kannan, V., Lee, A., Newhart, M., Heidler-Gary, J., Hillis, A.E. (2008)Where (in the brain) do semantic errors come from? Cortex. [Epub ahead of print]

Medina, J., Kannan, V., Pawlak, M., Kleinman, J.T., Newhart, M., Davis, C., Heidler-Gary J.E., Herskovits,
E.H., Hillis, A.E. (2008) Neural substrates of visuospatial processing in distinct reference frames: evidence from unilateral spatial neglect. Journal of Cognitive Neuroscience. [Epub ahead of print].

Cloutman, L., Gingis, L., Newhart, M., Davis, C., Heidler-Gary, J., Crinion, J., Hillis, A.E. (in press). A neural
network critical for spelling. Annals of Neurology.

Activities & Honors


  • Alpha Omega Alpha
  • Phi Beta Kappa
  • Research Fellow, National Stroke Association
  • Fellow, American Heart Association
  • Fellow, American Stroke Association
  • Derek Denny-Brown Neurological Scholar Award, American Neurological Association
  • Norman Geschwind Award in Behavioral Neurology, American Academy of Neurology
  • Best Doctors in America, 2014
  • Baltimore Top Docs 2015, Baltimore Magazine, 2015


  • Academy of Aphasia
  • American Academy of Neurology
    Section on Behavioral Neurology
  • American Heart Association Stroke Council
    Fellow;Abstract Reviewer for the International Stroke Conference (2003-2007); Scientific Session Chair, 2005, 2006
  • American Neurological Association
    Scientific Program Committee (2004-2006)
  • Clinical Aphasiology Conference
    Program committee 1985, 1992; Program Chair 2003; Conference Chair 2004; Steering Committee (2003-present)
  • Faculty 1000 Medicine
    Evaluation Board
  • Society for Neuroscience
  • World Federation of Neurology- Research Group on Aphasia and Cognitive Disorders
    Chair, 2004-2008
  • American Speech Language Association, 2015

    Advances in Diagnosis, Treatment, and Prognosis of Primary Progressive Aphasia

Videos & Media

Play Video:

The Johns Hopkins Hospital Comprehensive Stroke Center

Recent News Articles and Media Coverage

Argye Hillis Among Stoke Researchers Awarded $11 Million NIH Grant Press Release (4/20/16)

Dealing with the emotional aspects of stroke rehab, Philadelphia Inquirer (04/13/2014)

Why You Get the Joke: Brain's Sarcasm Center Found, Live Science

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

Is this you? Edit Profile
back to top button