Anthony K.L. Leung, Ph.D.

Headshot of Anthony K.L. Leung
  • Joint Appointment in Molecular Biology and Genetics

Research Interests

non-coding RNAs; RNA-binding proteins; post-translational modifications; PARP inhibitors; RNA granules; diagnostics; proteomics more



  • Joint Appointment in Molecular Biology and Genetics
  • Joint Appointment in Oncology

Departments / Divisions

Centers & Institutes



  • Ph.D.; University of Dundee (United Kingdom) (2003)

Research & Publications

Selected Publications

View all on PubMed

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. PNAS 2017; 114(7):1666-1671.

Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic acids research. 2017; 45(D1):D204-D209.

Daniels CM, Ong SE, Leung AK. Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells. Journal of proteome research. 2014; 13(8):3510-22.

Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 2011; 42(4):489-99.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AK (2019). ELTA: Enzymatic Labeling of Terminal ADP-ribose. Mol Cell 73:845-856.e5

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry and Molecular Biology (JHSPH)

Biochemistry, Cellular and Molecular Biology (JHSOM)

Human Genetics Program, Institute of Genetic Medicine (JHSOM)

Chemistry–Biology Interface (JHU)

Activities & Honors


  • Idea Award, Department of Defense Breast Cancer Research Program
  • Faculty Innovation Award, Johns Hopkins Bloomberg School of Public Health
  • Johns Hopkins Catalyst Award
  • American Cancer Society Research Scholar Award
  • Johns Hopkins Discovery Award
  • W. W. Smith Charitable Trust Medical Research Award
  • Teaching Excellence Award, Johns Hopkins Bloomberg School of Public Health
  • Shikani/El-Hibri Prize for Discovery & Innovation, Johns Hopkins Bloomberg School of Public Health

Patient Ratings & Comments

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