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Anthony K.L. Leung, Ph.D.

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  • Joint Appointment in Molecular Biology and Genetics

Research Interests

non-coding RNAs; RNA-binding proteins; post -translational modifications; PARP inhibitors; RNA granules; diagnostics; proteomics more



  • Joint Appointment in Molecular Biology and Genetics
  • Joint Appointment in Oncology

Departments / Divisions

Centers & Institutes



  • Ph.D.; University of Dundee (United Kingdom) (2003)

Research & Publications

Clinical Trials

Learn more about clinical trials at Johns Hopkins Medicine.

Selected Publications

View all on PubMed

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. PNAS 2017; 114(7):1666-1671.

Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic acids research. 2017; 45(D1):D204-D209.

Daniels CM, Ong SE, Leung AK. Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells. Journal of proteome research. 2014; 13(8):3510-22.

Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 2011; 42(4):489-99.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AK (2019). ELTA: Enzymatic Labeling of Terminal ADP-ribose. Mol Cell 73:845-856.e5

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry and Molecular Biology (JHSPH)

Biochemistry, Cellular and Molecular Biology (JHSOM)

Human Genetics Program, Institute of Genetic Medicine (JHSOM)

Chemistry–Biology Interface (JHU)

Activities & Honors


  • Idea Award, Department of Defense Breast Cancer Research Program
  • Faculty Innovation Award, Johns Hopkins Bloomberg School of Public Health
  • Johns Hopkins Catalyst Award
  • American Cancer Society Research Scholar Award
  • Johns Hopkins Discovery Award
  • W. W. Smith Charitable Trust Medical Research Award
  • Teaching Excellence Award, Johns Hopkins Bloomberg School of Public Health
  • Shikani/El-Hibri Prize for Discovery & Innovation, Johns Hopkins Bloomberg School of Public Health
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