non-coding RNAs; RNA-binding proteins; post -translational modifications; PARP inhibitors; RNA granules; diagnostics; proteomics ...read more
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McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. PNAS 2017; 114(7):1666-1671.
Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic acids research. 2017; 45(D1):D204-D209.
Daniels CM, Ong SE, Leung AK. Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells. Journal of proteome research. 2014; 13(8):3510-22.
Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 2011; 42(4):489-99.
Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AK (2019). ELTA: Enzymatic Labeling of Terminal ADP-ribose. Mol Cell 73:845-856.e5
Biochemistry and Molecular Biology (JHSPH)
Biochemistry, Cellular and Molecular Biology (JHSOM)
Human Genetics Program, Institute of Genetic Medicine (JHSOM)
Chemistry–Biology Interface (JHU)