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Amir Hossein Kashani, M.D., Ph.D.

Headshot of Amir Hossein Kashani
  • Associate Professor (PAR) of Ophthalmology


Diabetic Retinopathy, High Blood Pressure (Hypertension), Macular Degeneration, Macular Puckers, Ophthalmology, Retinal Artery Occlusion, Retinal Detachment, Retinal Vein Occlusion more

Research Interests

Diabetic Retinopathy; Retinal Vascular Disease; Stem Cell Therapy of Retinal Disease; OCT Angiography; Vascular Cognitive Impairment and Dementia more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-3518
600 N. Wolfe Street
Wilmer Eye Institute
Baltimore, MD 21287 map

Johns Hopkins Wilmer Eye Institute - Columbia

Appointment Phone: 410-910-2330
10710 Charter Drive
Medical Pavilion at Howard County, Suite 310
Columbia, MD 21044 map


Amir H. Kashani, M.D., Ph.D., is a retina specialist and surgeon treating patients at Wilmer Eye Institute’s East Baltimore and Columbia locations. Dr. Kashani specializes in the diagnosis and treatment of medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration, epiretinal membranes and retinal detachments as well as other common retinal diseases. 

Dr. Kashani is an NIH-funded clinician-scientist studying the pathophysiology of retinal vascular diseases, such as diabetic retinopathy, vascular cognitive impairment and dementia in human patients using cutting-edge, noninvasive imaging methods such as optical coherence tomography angiography. He has co-authored more than 50 peer-reviewed articles in the scientific literature, several subject reviews, and an ophthalmology handbook titled Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies. more


  • Associate Professor (PAR) of Ophthalmology

Departments / Divisions



  • MD PhD; Johns Hopkins University School of Medicine (2006)


  • Ophthalmology; LAC + USC Medical Center (2010)


  • Retina; Beaumont Hospital Royal Oak (2013)

Board Certifications

  • American Board of Ophthalmology (Ophthalmology) (2012)

Research & Publications

Research Summary

Retinal vascular diseases are among the leading cause of vision loss in the working age and older population. Over decades of life, diseases such as diabetic retinopathy and age-related macular degeneration can lead to dysfunction and abnormal growth of blood vessels. The earliest pathologic changes in these diseases occur at the level capillaries within and around the retina, but they are undetectable to the naked eye or to the doctor in the clinic until significant damage has been done.

Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases using advanced imaging methods that can detect the earliest changes in retinal capillaries before they are noticeable to the patient or doctor. For example, his research has demonstrated that impairment in retinal capillary blood flow is diffusely present and detectable in patients with the earliest stages of diabetic retinopathy. These changes are not only present in diabetes, but also in many systemic vascular diseases that impair blood vessel function such as hypertension, heart disease and cerebrovascular disease. Accurately detecting and quantifying these early capillary level changes would provide novel diagnostic tools for understanding the disease process, detecting disease progression and enabling development of targeted treatments. 

Dr. Kashani’s research has been recognized nationally and internationally. He is the lead investigator of the Optical Coherence Tomography Angiography initiative in the MarkVCID multicenter study funded by the National Institutes of Health and the Brightfocus Foundation. This five-year study aims to develop a clinically useful biomarker of retinal capillary changes to monitor the development of a prevalent form of cerebrovascular disease called vascular cognitive impairment and dementia. This is one of the leading causes of cognitive impairment, on par with Alzheimer’s disease. The preliminary results of this study have been published in the internationally recognized peer-reviewed journal Alzheimer’s and Dementia: Diagnosis, Assessment and Monitoring. 

Dr. Kashani is also the principal investigator for a first-in-man phase 1/2a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. For this study Dr. Kashani and the research team pioneered a novel surgical procedure to insert a sheet of cells underneath the damaged retina of 15 patients with geographic atrophy. The surgical methods and preliminary results of this study have been published in internationally recognized peer-reviewed journals including Opthalmology Retina and Science Translational Medicine.

Dr. Kashani’s work has been recognized nationally and internationally by his peers. In 2016, he was named one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017, he was named one of the top 50 “rising stars” worldwide in the field of ophthalmology by The Ophthalmologist. Dr. Kashani’s clinical work has been recognized by multiple organizations and publications including Pasadena Magazine’s Top Doctors, America’s Top Ophthalmologist, Best Doctors in America and Marquis Who’s Who in the World.

Clinical Trials

Learn more about clinical trials at Johns Hopkins Medicine.

Activities & Honors


  • ARVO Foundation for Research/Retina Research Foundation grant, ARVO, 2006
  • Medical Scientist Training Program fellowship, 1999
  • Research Travel Grant, ARVO, 2007
  • Resident Research Award, Department of Ophthalmology, University of Southern California, 2008
  • Henry and Lilian Nesburn Award, 2009
  • Heed Resident Research Symposium (Rank #4)
  • Ron G. Michel’s fellowship, 2012
  • Heed Ophthalmic Foundation fellow (Society of Heed Scholars), 2012
  • Nominated to 150 leading innovators in medical and surgical retina, Ocular Surgery News, 2016
  • Nominated to The Ophthalmologist’s Rising Stars Power List of ophthalmologists in the world, 2017


  • American Academy of Ophthalmology
  • Association for Research in Vision and Ophthalmology
  • American Society of Retina Specialists
  • American Academy for the Advancement of Science
  • Society of Heed Scholars
  • American Board of Ophthalmology


Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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