Abdel-Rahim A. Hamad, Ph.D., M.V.Sc.

Headshot of Abdel-Rahim A. Hamad
  • Associate Professor of Pathology

Research Interests

Type 1 diabetes; NKT cells; DN T cells; Obesity


Dr. Abdel R Hamad, B.V.Sc, M.V.Sc, Ph.D, is an Associate Professor of Pathology and Medicine. Dr. Hamad earned his B.V.Sc and M.V.Sc in veterinary medicine from the University of Khartoum and his Ph.D in immunology from the University of Colorado Health Science Center. He completed his postdoctoral training here at Johns Hopkins University School of Medicine and joined the Faculty in 2002. Dr. Hamad’s research has been continuously funded by the NIH and by private funding societies.

Dr. Hamad's research is focused on understanding pathophysiological roles of non-conventional immune lymphocytes in the regulation of autoimmunity, particularly type 1 diabetes (T1D), obesity and type 2 diabetes. He is also actively studying the role of non-conventional T cells in the regulation of immune responses to ischemia reperfusion injury (IRI).

Currently, Dr. Hamad is working along with Dr. Thomas Donner, Director of Diabetes at Johns Hopkins Hospital to translate these findings into strategies to better identify and protect individuals at risk for developing T1D. Along the way, they identified a subset of B cells that expresses Fas ligand and appears to be significantly increased in T1D patients and to cause insulitis in animal models.

In addition, Dr. Hamad is collaborating with Dr. Hamid Rabb to understand the role of a unique population of T cells that we discovered and, based our data, appear to play critical roles in the prevention of ischemia reperfusion injury (IRI), a major cause of death of kidney transplant recipients.

Dr. Hamad and his colleagues have discovered that syndecan 1 (sdc1), a heparan sulfate proteoglycan, is a specific marker of a subset of natural killer T cells (NKT) that produces IL-17 and resides exclusively in visceral adipose tissues. Deletion of sdc1 significantly reduces body fat and improves glucose tolerance in mice. Currently, Dr. Hamad and his colleagues are investigating the underlying mechanisms and finding ways to translate these findings into therapeutic for obesity.

Dr. Hamad has coauthored over 40 peer-reviewed publications and a book chapter in the fields of autoimmune diabetes, immune homeostasis and regulation. Dr. Hamad is a member of the editorial board of World Journal of Diabetes and Topic editor for Frontier in Immunology. He is also active in federal government advisory committees. He is an appointed member of HAI study section and served as ad hoc reviewer for several NIH study sections and for the European Research Council. He is also a member of American Association of Immunologists and B cell working group of the JDRF Network of Pancreatic Organ donor (nPOD) and Appointed member of NIH HAI study section.

...read more


  • Associate Professor of Pathology

Departments / Divisions

  • Pathology - Immunopathology



  • Ph.D.; University of Colorado Health Science Center (Colorado) (1996)
  • M.V.Sc.; University of Khartoum - Fac of Medicine - Khartoum - (Sudan) (1987)

Research & Publications


Lab Website: Hamad Laboratory

Selected Publications

View all on PubMed

Song Y, Bell DR, Ahmed R, Chan KC, Lee S, Hamad ARA, Zhou R. A mutagenesis study of autoantigen optimization for potential T1D vaccine design. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2214430120. doi: 10.1073/pnas.2214430120. Epub 2023 Apr 11. PubMed PMID: 37040399; PubMed Central PMCID: PMC10120010

Ahmed R, Ananth K, Omidian Z, Majety N, Zhang H, Hamad ARA. Detection, sorting, and immortalization of dual expresser lymphocytes from human peripheral blood samples. STAR Protoc. 2021 Dec 17;2(4):100925. doi: 10.1016/j.xpro.2021.100925. eCollection 2021 Dec 17. PubMed PMID: 34755121; PubMed Central PMCID: PMC8564191

Ahmed R, Omidian Z, Giwa A, Donner T, Jie C, Hamad ARA. A reply to "TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes". Cell. 2021 Feb 4;184(3):840-843. doi: 10.1016/j.cell.2020.11.036. PubMed PMID: 33545037; PubMed Central PMCID: PMC7935028

Saxena A, Khosraviani S, Noel S, Mohan D, Donner T, Hamad AR. Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy. Cytokine 74(1):27-34. 2015. PMID: 25481648

AK Jaiswal, M Sadasivam, ARA Hamad. Syndecan-1-coating of interleukin-17-producing natural killer T cells provides a specific method for their visualization and analysis. World Journal of Diabetes 8 (4), 130. 2017. PMID: 28465789. PMCID: PMC5394732

Academic Affiliations & Courses

Graduate Program Affiliation

  • Immunology Training program
  • Pediatrics training program
  • Pathobiology graduate program

Courses and Syllabi

  • Pathology and Disease Mechanisms (PDM)
  • Immunology Core Course

Activities & Honors


  • American Association of Immunologists (AAI), 1997

    The American Association of Immunologists is an association of professionally trained scientists from all over the world dedicated to advancing the knowledge of immunology and its related disciplines, fostering the interchange of ideas and information among investigators, and addressing the potential integration of immunologic principles into clinical practice.

    The American Association of Immunologists serves its members by providing a center for the dissemination of information relevant to the field and its practices, such as educational and professional opportunities, scientific meetings, membership-derived issues and opinions, and important social and political issues.

  • JDRF/ Network of Pancreatic Organ Donor (nPOD), 2011
Is this you? Edit Profile
back to top button