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Neurology and Neurosurgery

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Our Team


Jeffrey D. Rothstein, M.D., Ph.D., Investigator

photo of Dr. Jeffrey Rothstein in a lab coat

Dr. Rothstein is Professor of Neurology and Neuroscience and a faculty member of the Graduate Program in Cellular and Molecular Medicine at Johns Hopkins. He is the Founder and Director of the Robert Packard Center for ALS Research at Johns Hopkins. This is a multi-institutional, multi-national collaborative academic organization devoted toward understanding the cause of ALS and translating the information into new therapies. He is also the Director of the Brain Science Institute and directs the Brian Science Institute Neurotranslation program. He is also the Co-Director of the ALS Clinic.

His basic science laboratory interests include:

  • Regulation of astroglial glutamate and lactate transporter by protein-protein interactions, epigenetic, microRNA and genomic processing
  • Role of glutamate and lactate transporter regulation in abnormal synaptic transmission and neurodegeneration
  • The biology of astroglial in neurodegenerative disease
  • Various molecular mechanisms of selective neurodegeneration in motor neuron disease
  • Identification drugs and non-chemical means to modulate glutamate transporters and lactate transporters as therapeutics
  • The cloning and characterization of novel proteins which may be responsible for the cellular regulation of all glutamate transporter subtypes
  • The role of astrocytes and membrane transporters in normal and abnormal synaptic transmission.

Dr. Rothstein's Recent Research

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

Loss of Cerebellar Glutamate Transporters EAAT4 and GLAST Differentially Affects the Spontaneous Firing Pattern and Survival of Purkinje Cells

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To learn more about the ALS Center for Stem Cell and Regeneration Research at Johns Hopkins, please call 443-287-4341.
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