Web notes  

April 2018

Radiology Archives

1. Alizadeh M, Intintolo A, Middleton DM, Conklin CJ, Faro SH, Mulcahey MJ, Mohamed FB. Reduced field of view diffusion tensor imaging and fiber tractography of the pediatric cervical and thoracic spinal cord injury. Journal of Neurotrauma Feb. 1 2018 35:452-460 doi/10.1089/neu.2017.5174
Key words: Diffusion Tensor Imaging, MRI, Texture Analysis, Spine, Spinal cord
PMID: 27527237

2. Alizadeh M, Intintolo A, Middleton DM, Conklin CJ, Saksena S, Faro SH, Flanders A, Krisa L, Mulcahey MJ, Mohamed FB. Application of color transformation techniques in pediatric spinal cord MR images: typically developing and spinal cord injury population. J Digit Imaging. 2018 Jan 16. doi: 10.1007/s10278-017-0048-5. [Epub ahead of print]
Key words: Diffusion Tensor Imaging, MRI, Texture Analysis, Spine, Spinal cord
PMID: 29340396

3. Alizadeh M, Shah P, Middleton D, Conklin C, Saksena S, Faro SH, Mulcahey MJ, Finsterbusch J, Mohamed FB. Identification of ghost artifact using texture analysis in pediatric spinal cord diffusion tensor images. Magnetic Resonance Imaging. 2018 Apr;47:7-15.
Key words: Diffusion Tensor Imaging, MRI, Texture Analysis, Spine, Spinal cord
PMID: 29154897

4. Fatemi SH, Wong DF, Braši? JR, Kuwabara H, Mathur A, Folsom TD, Jacob S,. Realmuto GM, Pardo JV, Lee S. Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study. Cerebellum Ataxias. 2018;5:3.
Key words: cerebellum, postcentral gyrus, precuneus, [18F]-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile, rating scale
PMID: 29449954

5. O+sefsson A, Hobbs RF, Ranka S, Schwarz B, Plyku D, Willegaignon de Amorien de Carvalho J, Buchpiguel C, Sapienza M, Bolch W, Sgouros, G. Comparative Dosimetry for 68Ga-DOTATATE: Impact of using Updated ICRP phantoms, S values and Tissue Weighting Factors. J Nucl Med Feb 9, 2018; jnumed.117.203893.
Key words: PET/CT; Radiobiology/Dosimetry; Radiopharmaceuticals; Gallium-68-DOTATATE; PET/CT-imaging; dosimetry; effective dose; normal tissue
PMID: 29439017

6. Lai S, Heaphy CM, Rizzo AJ, Celentano DD, Gerstenblith G, Li J, Moore RD, Treisman G, Chen S, Foster P, Kickler T, Lai H. Cocaine use may induce telomere shortening in individuals with HIV infection. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;84(Pt A):11-17. doi: 10.1016/j.pnpbp.2018.01.015. [Epub ahead of print]
Key words: Cocaine use; HIV infection; HIV-associated comorbidities; Premature aging; Telomere length; Telomere shortening
PMID: 29410247

7. McDevitt MR, Sgouros G, Sofou S. Targeted and nontargeted ?-particle therapies. Annu Rev Biomed Eng. 2018 Jan 18. doi: 10.1146/annurev-bioeng-062117-120931. [Epub ahead of print]
Key words: ?-particle, actinium-225, radium-223, targeted therapy, radioimmunotherapy, nanoparticles
PMID: 29345977

1. Hwang BJ, Mohamed MA, Braši? JR. Molecular imaging of autism spectrum disorder. Int Rev Psychiatry. 2017 Dec;29(6):530-54.
Key words: dopamine; magnetic resonance spectroscopy; positron emission tomography; single photon emitted computed tomography; serotonin
PMID: 29231773

1. Gang GJ, Zbijewski W, Mahesh M, Thawait G, Packard N, Yorkston J, Demehri S,Siewerdsen JH. Image quality and dose for a multi-source cone-beam CT extremity scanner. Med Phys. 2017 Nov 9. doi: 10.1002/mp.12659. [Epub ahead of print]
Key words: Cone-beam CT, Extremity Scanner, Radiation Dose, Image Quality

2. Morin RL, Mahesh M. Radiation exposure and patient dose in cardiology. J Am Coll Radiol. 2017 Oct 20. pii: S1546-1440(17)31110-9. doi: 10.1016/j.jacr.2017.09.003. [Epub ahead of print] No abstract available.
Key words: Radiation dose, Catheterization procedures, flat panel detectors, Patient dose

1. Mahesh M. New conversion factors for estimating effective doses during cardiac CTA. JACC Cardiovasc Imaging. 2017 Aug 12. pii: S1936-878X(17)30699-X. doi: 10.1016/j.jcmg.2017.07.007. [Epub ahead of print] No abstract available.
Key words: Effective Dose, Conversion Factors, Cardiac CT

2. Marsh RM, Balter S, Mahesh M. Personal protective equipment in interventional fluoroscopy: distinguishing evidence from hype. J Am Coll Radiol. 2017 Sep 22. pii: S1546-1440(17)31009-8. doi: 10.1016/j.jacr.2017.08.017. [Epub ahead of print] No abstract available.
Key words: Fluoroscopy, Protective Equipment, Radiation Safety

3. Martin CJ, Vassileva J, Vano E, Mahesh M, Ebdon-Jackson S, Ng K, Frush DP, Loose R, Damilakis J. Unintended and accidental medical radiation exposures in radiology: guidelines on investigation and prevention. J Radiol Prot. 2017 Aug 24. doi: 10.1088/1361-6498/aa881e. [Epub ahead of print]
Key words: Radiation, Accidental Exposures, Prevention, Guidelines

4. Pacher P, Steffens S, Hasko G, Schindler TH, Kunos G. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad and the ugly. Nat Rev Cardiol. 2017 Sep 14. doi: 10.1038/nrcardio.2017.130. [Epub ahead of print] Review. (IF: 14.299)
Key words: endocannabinoids, cardiovascular, marijuana, cannabinoid receptors, central nervous system, obesity

1. Brasic JR. A 20-year-old man who stopped speaking. Medscape. Updated July 31, 2017.
Key words: autism spectrum disorders, movement disorder, catatonia, dopamine receptor blocking drugs, electroconvulsive treatments
No PMID available

2. Chareonthaitawee P, Beanlands RS, Chen W, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, DiCarli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. Joint SNMMI-ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring. Expert Consensus Document of the Cardiovascular Council of the Society of Nuclear Medicine and Molecular Imaging and the American Society of Nuclear Cardiology . J Nucl Cardiol. 2017 Aug 2. doi: 10.1007/s12350-017-0978-9. [Epub ahead of print]
Key words: FDG-PET, cardiac sarcoidosis, immunosuppression, position-paper

3. Chareonthaitawee P, Beanlands RS, Chen W, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, DiCarli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. The Role of PET/CT in Cardiac Sarcoid Detection and Monitoring Therapy. Expert Consensus Document of the Cardiovascular Council of the Society of Nuclear Medicine and Molecular Imaging and the American Society of Nuclear Cardiology. J Nucl Med. 2017 Aug;58(8):1341-1353. doi: 10.2967/jnumed.117.196287. (IF:6.6)
Key words: FDG-PET, cardiac sarcoidosis, immunosuppression, position-paper

4. Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine. Science. Aug 4;357(6350):503-507.
Key words: hM4Di, hM3Dq, neuromodulation, chemogenetics, designer receptors, designer drugs

5. Lesniak WG, Aboye T, Camarero JA, Chatterjee S, Camarero JA, Nimmagadda S. In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent. Chemistry. 2017 Aug 3. doi: 10.1002/chem.201702540. [Epub ahead of print]
Key words: CXCR4, cyclotide, molecular imaging, PET
PMID: 28771849

6. Leucker T, Valenta I, Schindler TH. PET-determined hyperemic flow, myocardial flow reserve and flow gradient - quo vadis? Front Cardiovasc Med 2017 Jul 17;4:46. doi: 10.3389/fcvm.2017.00046. eCollection 2017. Review.
Key words: CAD, FFR, myocardial blood flow, myocardial flow reserve, longitudinal flow gradient, PET

7. Nedrow JR, Josefsson A, Park S, Bäck T, Hobbs RF, Brayton C, Bruchertseifer F, Morgenstern A, Sgouros G. Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model. EJNMMI Res. 2017 Dec;7(1):57. doi: 10.1186/s13550-017-0303-2. Epub 2017 Jul 18.
Key words: Alpha-particle emitting radioimmunotherapy; Anti-PD-L1 antibodies; Dosimetry; Immune checkpoint inhibition; Pharmacokinetics

8. Nedrow JR, Josefsson A, Park S, Ranka S, Roy S, Sgouros G. Imaging of programmed death ligand-1 (PD-L1): impact of protein concentration on distribution of anti-PD-L1 SPECT agent in an immunocompetent melanoma murine model. J Nucl Med. 2017 May 18. pii: jnumed.117.193268. doi: 10.2967/jnumed.117.193268. [Epub ahead of print]
Key words: Animal Imaging; Molecular Imaging; SPECT; anti-PD-L1; immune checkpoint inhibitors; melanoma; targeted antibodies

1. Anderson BA, Kuwabara H, Wong DF, Roberts J, Rahmim A, Braši? JR, Courtney SM. Linking dopaminergic reward signals to the development of attentional bias: a positron emission tomographic study. NeuroImage. 2017 May 30;157:27-33. doi: 10.1016/j.neuroimage.2017.05.062.
Key words: Caudate nucleus; cerebral hemisphere; color-defined targets; dorsal striatum; neural mechanisms
PMID: 28572059

2. Schindler TH. Emergence of integrated cardiac magnetic resonance/positron emission tomography imaging as the preferred imaging modality in cardiac sarcoidosis. JACC Cardiovasc Imaging. 2017 Jun 9. pii: S1936-878X(17)30451-5. doi: 10.1016/j.jcmg.2017.02.022. [Epub ahead of print]
Key words: cardiac sarcoidosis, infiltrative disease, inflammation, perfusion, PET, CMR, MR-PET

1. Bennink LL, Smith DJ, Foss CA, Pomper MG, Li Y, Yu SM. High Serum Stability of Collagen Hybridizing Peptides and Their Fluorophore Conjugates. Mol Pharm. 2017 Jun 5;14(6):1906-1915. doi: 10.1021/acs.molpharmaceut.7b00009. Epub 2017 May 8.
Key words: collagen mimetic peptide; extracellular matrix; peptide degradation; proline peptidase pharmacokinetics; theranostics

2. Foss CA, Liu L, Mease RC, Wang H, Pasricha P, Pomper MG. Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with [125I]iodoDPA SPECT-CT. Mol Pharm. 2017 Jun 5;14(6):1906-1915. doi: 10.1021/acs.molpharmaceut.7b00009. Epub 2017 May 8.
Key words: FDG; Gastrointestinal; Molecular Imaging; SPECT/CT; TSPO; chronic pancreatitis; macrophages

3. Lai S, Gerstenblith G, Moore RD, Celentano DD, Bluemke DA, Treisman G, Liu CY, Li J, Chen S, Kickler T, Lai H. Cocaine use may modify HIV/ART-associated myocardial steatosis and hepatic steatosis. Drug Alcohol Depend. 2017 May 26;177:84-92. doi: 10.1016/j.drugalcdep.2017.03.029. [Epub ahead of print]
Key words: African Americans; Antiretroviral therapy; Cocaine use; HIV infection; Hepatic triglyceride content; Myocardial triglyceride content

4. Schindler TH. Another potential step to improve prosthetic heart valve endocarditis imaging with 18F-FDG PET/CT. Nucl Cardiol. 2017 Jun 5. doi: 10.1007/s12350-017-0935-7. [Epub ahead of print]
Key words: cardiac diseases, device infection, endocarditis, prosthetic valve, PET,.

1. Bar-Shir A, Alon L, Korrer MJ, Lim HS, Yadav NN, Kato Y, Pathak AP, Bulte JWM,
Gilad AA. Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy. Magn Reson Med. 2017 May 7. doi: 10.1002/mrm.26708. [Epub ahead of print]
Key words: MRI; Reporter gene; dendritic cells (DCs); drosophila melanogaster 2?-deoxynucleoside kinase (Dm-dNK); fluorescence-activated cell sorting (FACS); pyrrolo-2?-deoxycytidine (pyrrolo-dC)
PMID: 28480589

2. Brasic JR. Autism. Medscape Drugs & Diseases. Updated April 21, 2017.
Key words: checklist, communication, rating scales, screening, social interactions
No PMID available

3. Brasic JR. Tardive Dyskinesia. Medscape Reference. Updated April 24, 2017.
Key words: checklist, neuroleptics, rating scales, screening, movement disorders
No PMID available

4. Ganapathy-Kanniappan S. Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities. Biochim Biophys Acta. 2017 Apr 8; 1868(1):212-220.
Key words: cancer metabolism, immune evasion, immunotherapy


5. Ganapathy-Kanniappan S. Taming tumor glycolysis and potential implications for immunotherapy. Front Oncol. 2017 Mar 13;7:36.
Key words: Tumor glycolysis, tumor microenvironment, cancer immunotherapy, NK cell therapy

6. Mahesh M, Madsen M. Addressing technetium-99m shortage. J Am Coll Radiol. 2017 May;14(5):681-683. Epub 2017 Apr 2. No abstract available.
Key words: Technetium-99m, Nuclear Medicine Procedures, Supply-Demand of Tc-99m, Production of Tc-99m

7. Mahesh M, Morin RL. Physician leadership in radiation dose optimization. J Am Coll Radiol. 2017 May 2. pii: S1546-1440(17)30300-9.
Key words: Radiation Dose, Leadership Role, Dose Optimization

8. Rubin GD, Krishnaraj A, Mahesh M, Rajendran RR, Fishman EK. Enhancing public access to relevant and valued medical information: fresh directions for radiologyInfo.org. J Am Coll Radiol. 2017 May;14(5):697-702.e4. Epub 2017 Jan 28.
Key words: Radiologyinfo.org, Public access, Radiology Information, Radiation Dose, Patient Safety

1. Gregg L, Eckart Sorte D, Gailloud P. Intraforaminal location of thoracolumbar radicular arteries providing an anterior radiculomedullary artery using flat-panel catheter angiotomography. Am J Neuroradiol. 2017 Feb 16. doi: 10.3174/ajnr.A5104. [Epub ahead of print]
Key words: radicular artery, flat-panel catheter angiotomography, transforaminal epidural steroid injection

1. Jha AK, Frey E. No-gold-standard evaluation of image-acquisition methods using patient data. Proc. SPIE 10136, Medical Imaging 2017. March 2017; 101360L
Key words: Image quality, quantitative imaging
No PMID available

2. Jha AK, Mena E, Caffo B, Ashrafinia S, Rahmim A, Frey EC, Subramaniam R. Practical no-gold-standard framework to evaluate quantitative imaging methods: Application to lesion segmentation in PET. J. Med. Imag.(Special Section on PET imaging) 2017 Jan; 4(1); 011011.
Key words: PET imaging, tumor segmentation, cancer
PMID: 28331883

3. Jha AK, Zhu Y, Wong DF, Rahmim A. A radiative transfer equation-based image-reconstruction method incorporating boundary conditions for diffuse optical imaging. Proc. SPIE 10137, Medical Imaging 2017: 1013705; March 13, 2017.
Key words: Optical imaging, Photon transport
No PMID Available

4. Mena E, Sheikhbahaei S, Taghipour M, Jha AK, Xiao J, Vicente E, Subramaniam RM, 18F-FDG PET/CT Metabolic tumor volume and intra-tumoral heterogeneity: impact of dual-time-point and segmentation methods. Clin. Nuc. Med. Jan. 2017; 42(1)
Key words: Tumor heterogeneity, FDG-PET imaging, tumor segmentation, cancer

5. Mena E, Taghipour M, Sheikhbahaei S, Jha AK, Solnes L, Subramaniam RM, Value of intra-tumoral metabolic heterogeneity and quantitative 18F-FDG PET/CT parameters to predict prognosis, in patients with HPV-positive primary oropharyngeal squamous cell carcinoma. Clin. Nuc. Med. 2017 Feb 13.
Key words: Tumor heterogeneity, FDG-PET imaging, cancer

6. Zhu Y, Jha AK, Dreyer JK, Le H, Kang JU, Roland PE, Wong DF, Rahmim A. A three-step reconstruction method for fluorescence molecular tomography based on compressive sensing. Proc. SPIE 10059 17 Feb 2017; 1005911
Key words: Optical imaging, Transcranial imaging

1. Kruse MJ, Kovell L, Kasper EK, Pomper MG, Moller DR, Solnes L, Chen ES, Schindler TH. Myocardial blood flow and inflammatory cardiac sarcoidosis. JACC Cardiovasc Imaging. 2017 Feb;10(2):157-167. doi: 10.1016/j.jcmg.2016.09.023.
Key words: fibrosis, inflammation, myocardial blood flow, necrosis, PET, sarcoidosis

2. Schindler TH. Cardiovascular PET/MR:"Not the end but the beginning." J Nucl Cardiol. 2017 Jan 26. doi: 10.1007/s12350-017-0784-4. [Epub ahead of print].
Key words: cardiac diseases, infiltrative disease ,MRI, PET, sarcoidosis, viability

3. Sebastian R, Saxena S, Tsapkini K, Faria AV, Long C, Wright A, Davis C, Tippett DC, Mourdoukoutas AP, Bikson M, Celnik P, Hillis AE. Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke. Front Hum Neurosci. 2017 Jan 12;10:695.
Key words: aphasia, cerebellar tDCS, resting state fMRI, spelling therapy, stroke

1. Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S. Rapid PD-L1 detection in tumors with PET using a highly specific peptide. Biochem Biophys Res Commun. 2016 Dec 24; pii: S0006-291X(16)32216-1.
Key words: Immunotherapy; Immune checkpoint; Diagnostics; Peptides; PD-1.

2. Mahesh M, Barker PB. The MRI helium crisis: past and future. J Am Coll Radiol. 2016 Dec;13(12 Pt A):1536-1537. doi: 10.1016/j.jacr.2016.07.038. No abstract available.
Key words: Magnetic Resonance Imaging, Helium, MR Technology, MR scanners, Helium Reserves

3. Quercioli A, Carbone F, Bonaventura A, Liberale L, Pataky Z, Thomas A, Lenglet S, Lauer E, Golay A, Dallegri F, Di Marzo V, Schindler TH, Montecucco F. Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function. Int J Cardiol. 2016 Dec 13. pii: S0167-5273(16)32953-9. doi: 10.1016/j.ijcard.2016.12.023. [Epub ahead of print]
Key words: CAD, coronary circulation, endocannabinoids, myocardial blood flow, obesity, PET, vasomotor function

1. Coughlin JM, Wang Y, Minn I, Bienko N, Ambinder EB, Xu X, Peters ME, Dougherty JW, Vranesic M, Koo SM, Ahn H-H, Lee M, Cottrell C, Sair HI, Sawa A, Munro CA, Nowinski CJ, Dannals RF, Lyketsos CG, Kassiou M, Smith G, Caffo B, Mori S, Guilarte TR, Pomper MG. Imaging of glial cell activation and white matter integrity in the brains of active and recently retired National Football League players. JAMA Neurol. 2017 Jan 1;74(1):67-74.
Key words: NFL, TBI, TSPO, Neuro PET, DTI

2. Hapuarachchige S, Artemov D. Click chemistry in the development of contrast agents for magnetic resonance imaging. Top Magn Reson Imaging. 2016 October;25(5):205-213.
Key words: Magnetic resonance imaging; targeted imaging agents; click chemistry

3. Mahesh M, Morin RL. Radiation changes in the 21st century. J Am Coll Radiol. 2016 Nov;13(11):1404. doi: 10.1016/j.jacr.2016.07.002. No abstract available.
Key words: Computed Tomography, Radiation Dose, Medical Imaging

4. Yang H, Schaffer K, Liu L, Mahesh M, Yousem DM. Benchmarking lumbar puncture fluoroscopy time during fellowship training. AJNR Am J Neuroradiol. 2016 Dec 1. [Epub ahead of print]
Key words: Fluoroscopy, Radiation Exposure, Training

1. Liu P, Welch BG, Li Y, Gu H, King D, Yang Y, Pinho M, Lu, H. Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI. NeuroImage: 2016 Sep 28. Pii: S1053-8119(16)30541-9. doi: 10.1016/j.neuroimage.2016.09.063.
Key words: Cerebrovascular reactivity, Venous cerebral blood volume, Resting-state functional connectivity, Bolus arrival time

2. Ngen EJ, Bar-Shir A, Jablonska A, Liu G, Song X, Ansari R, Bulte JW, Janowski M, Pearl M, Walczak P, Gilad AA. Imaging the DNA alkylator melphalan by CEST MRI: an advanced approach to theranostics. Mol Pharm. 2016 Sep 6;13(9):3043-53. doi: 10.1021/acs.molpharmaceut.6b00130.
Key words: CEST, MRI, drug imaging, melphalan, theranostics, therapeutic response assessment
PMID: 27398883

1. Schindler TH, Marashdeh W, Solnes L. Clinical application of myocardial blood flow quantification in CAD patients. Ann Nucl Cardiol. 2016; 2(1):85-93. (review)
Key words: CAD, microcirculation, myocardial blood flow, myocardial flow reserve, PET
No URL available

2. Valenta I, Mirpour S, Marashdeh W, Schindler TH. Potential role of cardiovascular imaging in improving cardiovascular outcome in coronary artery disease. Curr Pharm Des. 2016 Aug 13 [Epub ahead of print] (IF: 3.05)
Key words: CAD, coronary artery calcifications, cardiac CT, CT coronary angiography, myocardial blood flow, myocardial flow reserve, PET, prevention, risk stratification

3. Xie M, Vesuna F, Tantravedi S, Bol GM, Heerma van Voss MR, Nugent K, Malek R, Gabrielson KL, Van Diest PJ, Tran PT, Raman V. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.Cancer Res. 2016 Sep 12; doi: 10.1158/0008-5472.CAN-16-0440 [Epub ahead of print]
Key words: prostate cancer, DDX3, RK-33, radiosensitizer

4. Yalcin H, Valenta I, Yalcin F, Corona-Villalobos, Vasquez N, Ra J, Kucukler N, Tahari A, Pozios I, Zhou Y, Pomper MG, Abraham TP, Schindler TH, Abraham RM. Effect of diffuse subendocardial hypoperfusion on left ventricular cavity size by 13N-ammonia perfusion PET in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2016; Sep 15. pii: S0002-9149(16)31501-6. doi: 10.1016/j.amjcard.2016.08.085. [Epub ahead of print]
Key words: hypertrophic obstructive Cardiomyopathy, microcirculation, myocardial blood flow, myocardial flow reserve, PET

1. Zhu W, Harvey S, Macura KJ, Euhus DM, Artemov D. Invasive breast cancer preferably and predominantly occurs at the interface between fibroglandular and adipose tissue. Clin Breast Cancer. 2016 Jul 28. pii: S1526-8209(16):30202-6.
Key words: Breast cancer, MRI, adipose tissue, tissue interface
PMID: 27568102

1. Liu H, Jablonska A, Li Y, Cao S, Liu D, Chen H, Van Zijl PC, Bulte JW, Janowski M, Walczak P, Liu G. Label-free CEST MRI detection of citicoline-liposome drug delivery in ischemic stroke. Theranostics. 2016 June 18, 6(10):1588-1600.
Key words: Ischemia, stroke, citicoline, liposome, theranostic, CEST MRI

1. Hapuarachchige S, Kato Y, Ngen EJ, Smith B, Delannoy M, Artemov D. Non-temperature induced effects of magnetized iron oxide nanoparticles in alternating magnetic field in cancer cells.
PLoS One. 2016 May 31;11(5):e0156294. doi: 10.1371/journal.pone.0156294. eCollection 2016.
Key words: magnetic iron oxide nanoparticles, MRI, oscillating gradient, cancer therapy, apoptosis

2. Valenta I, Antoniou A, Marashdeh W, Leucker T, Kasper E, Jones SR, Dannals RF, Solnes L, Pomper MG, Schindler TH. PET-measured longitudinal flow gradient correlates with invasive fractional flow reserve in CAD patients. Eur Heart J Cardiovasc Imaging. 2016 Jun 19. pii: jew116. [Epub ahead of print]
Key words: CAD, flow gradient, fractional flow reserve, myocardial blood flow, myocardial flow reserve, PET

1. Brasic JR. A 9-year-old boy exhibiting violent behavior. Medscape. Case Challenge. Updated May 31, 2016.
Key words: Conductive hearing loss, Continuum of causality, Hallucinations, Psychosis, Suicide
No PMID available

2. Koniusz S, Andrzejewska A, Muraca M, Srivastava AK, Janowski M, Lukomska B. Extracellular vesicles in physiology, pathology, and therapy of the immune and central nervous system, with focus on extracellular vesicles derived from mesenchymal stem cells as therapeutic tools. Front Cell Neurosci. 2016 May 2;10:109
Key words: Extracellular vesicles, Exosomes, Mesenchymal stem cells, Immune system, Central Nervous System

3. Mahesh M, Morin RL. CT scans and cancer risks-a practical middle path. J Am Coll Radiol. 2016 May 28. pii: S1546-1440(16)30188-0. doi: 10.1016/j.jacr.2016.04.008.
Key words: CT scans, Radiation Risks, Radiation Dose

4. Nowakowski A, Walczak P, Lukomska B, Janowski M. Genetic engineering of mesenchymal stem cells to induce their migration and survival. Stem Cells Int. 2016;2016:4956063. Epub 2016 May 3
Key words: Genetic engineering, Mesenchymal Stem Cells, Migration, Survival

1. Khamwan K, Plyku D, O'Reilly SE, Goodkind A, Cao X, Fahey FH, Treves ST, Bolch WE, Sgouros G. Pharmacokinetic modeling of [(18)F]fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds. EJNMMI Res. 2016 Dec;6(1):28. doi: 10.1186/s13550-016-0179-6.
Key words: Compartmental modeling, FDG, Pediatric imaging, Pharmacokinetics

2. Lai H, Moore R, Celentano DD, Gerstenblith G, Treisman G, Keruly JC, Kickler T, Li J, Chen S, Lai S, Fishman EK. HIV infection itself may not be associated with subclinical coronary artery disease among African Americans without cardiovascular symptoms. J Am Heart Assoc. 2016 Mar 24;5(3). pii: e002529. doi: 10.1161/JAHA.115.002529.
Key words: coronary CT angiography, HIV infection, subclinical coronary atherosclerosis
PMID: 27013538

3. O'Reilly SE, Plyku D, Sgouros G, Fahey FH, Ted Treves S, Frey EC, Bolch WE. A risk index for pediatric patients undergoing diagnostic imaging with (99m)Tc-dimercaptosuccinic acid that accounts for body habitus. Phys Med Biol. 2016 Mar 21;61(6):2319-32. doi: 10.1088/0031-9155/61/6/2319. Epub 2016 Mar 1.
Key words: dose reduction, dosimetry, DMSA, pediatric imaging, renal

4. Yoshida T, Jin K, Song H, Park S, Huso DL, Zhang Z, Liangfeng H, Zhu C, Bruchertseifer F, Morgenstern A, Sgouros G, Sukumar S. Effective treatment of ductal carcinoma in situ with a HER-2- targeted alpha-particle emitting radionuclide in a preclinical model of human breast cancer. Oncotarget. 2016 Apr 23. doi: 10.18632/oncotarget.8949. [Epub ahead of print]
Key words: breast cancer, ductal carcinoma in situ, intraductal, radioimmunotherapy, trastuzumab

1. Gispen FE, Magid D. Assessing medical student knowledge of imaging modality selection before and after a general radiology elective: a comparison of MS-IIs, MS-IIIs, and MS-IVs. Academic Radiology. In press. Available online 2016 March 15.
Key words: radiology, education, curriculum, ACR-AC, imaging selection

2. Hapuarachchige S, Kato Y, Artemov D. Bioorthogonal two-component drug delivery in HER2(+) breast cancer mouse models. Scientific Reports. 2016 Apr 12;6:24298.
Key words: HER2+ breast cancer, Pretargeting therapy, Bioorthogonal chemistry
PMID: 27068794

3. Ngen EJ, Wang L, Gandhi N, Kato Y, Armour M, Zhu W, Wong J, Gabrielson KL, Artemov D. A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies. J Neurooncol. 2016 Mar 28. [Epub ahead of print]
Key words: Radiation brain damage, Stem cell therapy, Brain MRI
PMID: 27021492

1. Akazawa K, Chang L, Yamakawa R, Hayama S, Buchthal S, Alicata D, Andres T, Castillo D, Oishi K, Skranes J, Ernst T, Oishi, K. Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: Application to evaluate longitudinal developmental trajectories in term-born and preterm-born infants. NeuroImage. 2016 Mar;128:167-79.
Key words : Diffusion tensor imaging, Functional pathway, Neonate, Preterm birth, Probabilistic map, Tractography

2. Behnam Azad B, Chatterjee S, Lisok A, Lesniak W, Pullambhatla M, Pomper MG, Nimmagadda S. A full human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts. Oncotarget. 2016 Feb 1. doi: 10.18632/oncotarget.7111. [Epub ahead of print]
Key words: Zirconium-89, cancer therapy, chemokine receptor, molecular imaging, precision medicine

3. Behnam Azad B, Chatterjee S, Poierier JT, Lisok A, Lesniak W, Pullambhatla M, Luker G, Pomper MG, Nimmagadda S. Targeted imaging of the atypical chemokine receptor 3 (ACKR3/CXCR7) in human cancer xenografts. J Nucl Med. 2016 Feb 23. pii: jnumed.115.167932. [Epub ahead of print]
Key words: Breast Cancer, Lung Cancer, Molecular Imaging, Radioimmunoimaging, Tumor Microenvironment

4. Boone JM, Mahesh M, Gingold EL, Seibert JA. A call for the structured physicist report. J Am Coll Radiol. 2016 Mar; 13(3):307-9. doi: 10.1016/j.jacr.2015.12.016. No abstract available.
Key words: Physics Report, Quality Control, Radiation Dose, Radiation Dose Descriptors

5. Chang L, Akazawa K, Yamakawa R, Hayama S, Buchthal S, Alicata D, Andres T, Castillo D, Oishi K, Skranes J, Ernst T, Oishi K. Delayed early developmental trajectories of white matter tracts of functional pathways in preterm-born infants: Longitudinal diffusion tensor imaging data. Data Brief. 2016 Feb; 6:1007-15.
Key words: Atlas, Diffusion tensor imaging, Infant, Preterm, Term

6. Chatterjee S, Lesniak W, Gabrielson M, Lisok A, Wharram B, Sysa-Shah P, Behnam Azad B, Poper MG, Nimmagadda S. A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors. Oncotarget. 2016 Feb 2. doi: 10.18632/oncotarget.7143. [Epub ahead of print]
Key words: MPDL3280A; immune escape; immunotherapy; molecular imaging; personalized medicine

7. Elshahaby FEA, Ghaly M, Jha AK, Frey EC. Factors affecting the normality of anthropomorphic channel outputs: an investigation using realistic myocardial perfusion SPECT images. 2016 Jan;3(1):015503.
Key words: SPECT, observer studies, image-quality evaluation

8. Jha AK, Caffo B, Frey EC. A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods. Phys Med Biol. 2016 Apr 7;61(7):2780-800.
Key words: Quantitative imaging, no-gold-standard evaluation, SPECT, reconstruction methods

9. Jha AK, Rodriguez JJ, Stopeck AT. A maximum-likelihood method to estimate a single ADC value of lesions using diffusion MRI. Mag Res Med. 2016 Jan 7. doi: 10.1002/mrm.26072.
Key words: Diffusion MRI, ADC estimation, quantitative imaging biomarkers

10. Lesniak W, Oskolkov N, Yang X, Pomper MG, Nimmagadda S, McMahon MT. Salicylic acid conjugated dendrimers are a tunable, high performance CEST MRI nanoplatform. Nano Lett. 2016 Mar 1. [Epub ahead of print]
Key words: CED; chemical exchange saturation transfer (CEST); dendrimers; glioblastoma; salicylic acid

1. Kesner AL, Daou D, Schindler TH, Koo PJ. Carpe Datum: a consideration of the barriers and potential of data-driven PET innovation. J Am Coll Radiol. 2016 Jan;13(1):106-8. doi: 10.1016/j.jacr.2015.07.009. [Epub 2015 Oct 21].
Key words: Data management, diagnosis, PET

2. Mahesh M. What is the CT dose check standard, and why do CT scanners need to be in compliance? J Am Coll Radiol. 2015 Dec 1. pii: S1546-1440(15)01064-9. doi: 10.1016/j.jacr.2015.10.002. [Epub ahead of print]
Key words: CT, Radiation, CT Dose Check, Regulatory Compliance

3. Salazar-Austin N, Ordonez AA, Hsu AJ, Benson JE, Mahesh M, Menachery E, Razeq JH, Salfinger
M, Starke JR, Milstone AM, Parrish N, Nuermberger EL, Jain SK. Extensively drug-resistant tuberculosis in a young child after travel to India. Lancet Infect Dis. 2015 Dec; 15(12):1485-91. doi: 10.1016/S1473-3099(15)00356-4. Epub 2015 Nov 16. Review.
Key words: Tuberculosis, CT scan, Treatment Evaluation, Drug-resistant Tuberculosis

4. Schindler TH. Myocardial blood flow: Putting it into clinical perspective. J Nucl Cardiol. 2015 Dec 28. [Epub ahead of print] (impact factor 2.6)
Key words: CAD, myocardial blood flow, myocardial flow reserve, PET

1. Josefsson A, Nedrow JR, Park S, Ray Banerjee S, Rittenbach A, Jammes F, Tsui B, Sgouros G. Imaging, biodistribution, and dosimetry of radionuclide-labeled PD-L1 antibody in an immunocompetent mouse model of breast cancer. Cancer Res. 2015 Nov 10. pii: canres.2141.2015. [Epub ahead of print]
Key words: Anti-PD-L1, antibodies, radiopharmaceutical therapy, immune checkpoint inhibitors, combination therapy

2. Plyku D, Loeb DM, Prideaux AR, Baechler S, Wahl RL, Sgouros G, Hobbs RF. Strengths and weaknesses of a planar whole-body method of (153)Sm Dosimetry for patients with metastatic osteosarcoma and comparison with three-dimensional dosimetry. Cancer Biother Radiopharm. 2015 Nov;30(9):369-79. doi: 10.1089/cbr.2014.1803
Key words: dosimetry, imaging,osteosarcoma, radionuclide therapy, radiopharmaceuticals

3. Woliner-van der Weg W, Schoffelen R, Hobbs RF, Gotthardt M, Goldenberg DM, Sharkey RM, Slump CH, van der Graaf WT, Oyen WJ, Boerman OC, Sgouros G, Visser EP. Tumor and red bone marrow dosimetry: comparison of methods for prospective treatment planning in pretargeted radioimmunotherapy. EJNMMI Phys. 2015 Dec;2(1):5. doi: 10.1186/s40658-014-0104-x.
Key words: patient-specific dosimetry, radiopharmaceutical therapy, 3-D radiobiological dosimetry

4. Zhu W, Huang P, Macura KJ, Artemov D. Association between breast cancer, breast density, and body adiposity evaluated by MRI. Eur Radiol. 2015 Oct 21. [Epub ahead of print].
Key words: Adiposity, Age, Breast cancer, Breast density, Magnetic resonance imaging

1. Chang KJ, Heisler MA, Mahesh M, Baird GL, Mayo-Smith WW. CT colonography at low tube potential: using iterative reconstruction to decrease noise. Clin Radiol. 2015 Sep;70(9):981-8. doi: 10.1016/j.crad.2015.05.005.
Key words: CT, Virtual Colonography, Tube voltage, Radiation Dose, Iterative reconstruction

2. Johnson PT, Mahesh M, Fishman EK. Image wisely and choosing wisely: importance of adult body CT protocol design for patient safety, exam quality, and diagnostic efficacy. J Am Coll Radiol. 2015 Nov;12(11):1185-90. doi: 10.1016/j.jacr.2015.02.021.
Key words: Body CT, CT protocol design, Image Wisely, Choosing Wisely

3. Kesner AL, Daou D, Schindler TH, Koo PJ. Carpe datum: a consideration of the barriers and potential of data-driven PET innovation. J Am Coll Radiol. 2015 Oct 20. pii: S1546-1440(15)00682-1. doi: 10.1016/j.jacr.2015.07.009. [Epub ahead of print] No abstract available.
Key words: PET, data, quantification

4. Mahesh M. Update on radiation safety and dose reduction in pediatric neuroradiology. Pediatr Radiol. 2015 Sep;45 Suppl 3:370-4. doi: 10.1007/s00247-015-3379-8. Epub 2015 Sep 7.
Key words: Radiation Safety, Radiation Dose, CT, Image Quality

5. Montecucco F, Carbone F, Schindler TH. Pathophysiology of ST-segment elevation myocardial infarction: novel mechanisms and treatments. Eur Heart J. 2015 Nov 4. pii: ehv592. [Epub ahead of print] Review.
Key words: CAD, cardiovascular risk factors, myocardial infarction, STEMI, stem cells, reperfusion injury, pre- and post-conditioning

6. Rao AD, Sugar EA, Barrett N, Mahesh M, Arceci RJ. The utility of computed tomography in the management of fever and neutropenia in pediatric oncology. Pediatr Blood Cancer. 2015 Oct;62(10):1761-7. doi: 10.1002/pbc.25561.
Key words: CT Imaging, Oncology patients, CT utility

1. Madar I, Naor E, Holt D, Ravert H, Dannals R, Wahl R. Unraveling the physiology of brown adipose tissue thermogenesis in vivo using dynamic voltage-dependent imaging. World Biomedical Frontiers -Obesity. Oct. 2015
Key words: 18F-FBnTP; PET imaging; Mitochondria; Brown adipose tissue; Obesity
no PMID available

1. Ngen EJ, Wang L, Kato Y, Krishnamachary B, Zhu W, Gandhi N, Smith B, Armour M, Wong J, Gabrielson K, Artemov D. Imaging transplanted stem cells in real time using an MRI dual-contrast method. Sci Rep. 2015 Sep 2;5:13628.
Key words: stem cell tracking, MR imaging, dual contrast, brain lesion, radiation necrosis

1. Madar I, Naor E, Holt D, Ravert H, Dannals R, Wahl R. Brown adipose tissue response dynamics: in vivo insights with the voltage sensor 18f-fluorobenzyl triphenyl phosphonium. PLoS One. 2015 Jun 8;10(6):e0129627.
Key words: positron emission tomography; brown adipose tissue; thermogenesis; mitochondria; 18F-fluorobenzyl triphenyl phosphonium; FBnTP; BAT response kinetics; Rats; UCP1; proton gradient

1. Kato Y, Zhu W, Backer MV, Neoh CC, Hapuarachchige S, Sarkar SK, Backer JM, Artemov D. Noninvasive imaging of liposomal delivery of superparamagnetic iron oxide nanoparticles to orthotopic human breast tumor in mice. Pharm Res. 2015 Jun 16. [Epub ahead of print].
Key words: liposomes; magnetic resonance imaging (MRI); passive targeting; single-chain vascular endothelial growth factor (scVEGF); superparamagnetic iron oxide nanoparticles (SPIONs)
PMID: 26078000

2. Lai H, Stitzer, M, Treisman G, Moore R, Brinker J, Gerstenblith G, Kickler T, Chen S, Fishman E, Lai S. Cocaine abstinence and reduced use associated with lowered marker of endothelial dysfunction in Africa Americans: a preliminary study. J Addict Med. 2015 July 7. [Epub ahead of print]
Key words: African Americans, cocaine use, coronary plaque progression, endothelin-1, incidence

PMID: 26164164

3. Schindler TH. Cardiac PET/CT applications and cardiovascular outcome. PET Clinics. 2015 Jul 10(3):441-59 [Epub ahead of print]) (IF: not available)
Key words: coronary artery disease, myocardial blood flow, myocardial flow reserve, outcome, PET

1. Acampa W, Gaemperli O, Gimelli A, Knappen P, Schindler TH, Verberne HJ, Zellweger MJ. Role of risk stratification by SPECT, PET and Hybrid Imaging in guided management of stable patients with suspected and known coronary artery disease: Expert panel of the EANM Cardiovascular Committee and ESC. Eur Heart J Cardiovascular Imaging 2015; Apr 22. pii: jev093. [Epub ahead of print] (IF: 3.68)
Key words: CAD, cardiovascular risk, diabetes, elderly, ischemic heart disease, myocardial perfusion, PET, SPECT, PET

1. Schindler TH. CZT-Camera: Moving beyond classical CAD detection? Eur J Nucl Med Mol Imaging. 2015 Mar 24. [Epub ahead of print]
Key words: Coronary artery disease, ischemia, CZT-camera, cardiac risk stratification

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April 2018 articles:
Training Sessions: Relying on an External IRB (JHM IRB)
Fee Schedule Adjustment for Hospital Services Charged to Clinical Trial Budgets
Change in Federalwide Assurance [FWA] Numbers
Changes to NIH-funded Human Subjects Research
Free Resources for Longitudinal Clinical Research Studies
NIH requirement for Single IRB (sIRB)
JHM IRB Reliance Requests
Sharing Partnership for Innovative Research in Translation
Johns Hopkins Institute for Clinical and Translational Research
Johns Hopkins Research Network
Visit Animal Care and Use Committee Website
Current Classes
"Interinstitutional Assurance" Agreement
Health, Safety, and Environment (HSE) presents: Safety in Research Updates
Takeda Pharmaceutical Company Innovators in Science Award
Arnold and Mabel Beckman Foundation Scholars Program
Michael J. Fox Foundation (MJFF) Challenge
Why Project Outcomes Matter in your Interim and Final Research Performance Progress Report (RPPR)
NIH Matchmaker, A Tool For Finding Similar NIH Projects
NIH Video Tutorials on How to Apply for Grants
NIH Policy: Foreign Components Added to a Grant to a Domestic or Foreign Organization

This Month's Departmental Listings

Upcoming Deadlines for April, May and June

April Events at the Genetic Resources Core Facility


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