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protein acetylation. Meth Enz 2004;376:188-199. Key words: malaria, plasmodium, trioxane, antimalarial, chemotherapy http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= pubmed&dopt=Abstract&list_uids=14971910 1. Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR. Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther 2004;75:60-69. Key words: abciximab, pharmacodynamics, neural network, platelets http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids= 14749692&dopt=Abstract 1. Cole PA, Shen K, Qiao
Y, Wang D. Protein tyrosine kinases Src and Csk: A tail's tale. Curr Opin
Chem Biol 2003;7:580-5. 2. Mager DE, Mascelli MA, Kleiman NS, Fitzgerald
DJ, Abernethy DR. Simultaneous modeling of abciximab plasma concentrations
and ex vivo pharmacodynamics in patients undergoing coronary angioplasty.
J Pharmacol Exp Ther 2003;307:969-76. 3. Nagababu E, Ramasamy S, Abernethy DR, Rifkind
JM. Active nitric oxide produced in the red cell under hypoxic conditions
by deoxyhemoglobin mediated nitrite reduction. J Biol Chem 2003;278:46349-56,2003. 4. Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L,
Flexner CW, Alper SL, Lencer WI. Diarrhea-associated HIV-1 aspartyl protease-inhibitors
potentiate muscarinic Cl- secretion by T84 cells via prolongation of cytosolic
Ca2+ signaling. Am J Physiol Cell Physiol 2003 Dec 30;[Epub ahead of print]. 5. Shen K, Cole PA. Conversion of a tyrosine kinase
protein substrate to a high affinity ligand by ATP linkage. J Am Chem
Soc 2003;125:16172-3. 6. Thayer JF, Merritt MM, Sollers JJ, Zonderman
AB, Evans MK, Yie S, Abernethy DR. Effect of angiotensin converting enzyme
insertion/deletion polymorphism DD genotype on high-frequency heart rate
variability in African Americans. Am J Cardiol 2003;92:1487-90. 7. Zheng W, Zhang Z, Ganguly, S, Weller, JL, Klein
D, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced
by non-hydrolyzable phosphonate incorporation. Nature Structural Biology
2003;10:1054-7. 1. Benson CA, Williams PL, Currier JS, Holland F,
Mahon LF, MacGregor RR,Inderlied CB, Flexner C, Neidig J, Chaisson R,
Notario GF, Hafner R. A prospective, randomized trial examining the efficacy
and safety of clarithromycin in combination with ethambutol, rifabutin,
or both for the treatment of disseminated Mycobacterium avium complex
disease in persons 2. Cao C, Kwon K, Jiang YL, Stivers JT. Solution
structure and base perturbation studies reveal a novel mode of alkylated
base recognition by 3-methyladenine DNA glycosylase I. J Biol Chem 2003;278:48012-48020. 3. Katz J, Feldman MA, Bass EB, Lubomski LH, Tielsch
JM, Petty BG, Fleisher LA, Schein OD. Risks and benefits of anticoagulant
and antiplatelet medication use before cataract surgery. Ophthalmology
2003;110:1784-1788. 4. Kwak MK, Wakabayashi N, Greenlaw, JL, Yamamoto
M, Kensler TW. Antioxidants Key words: DNA repair, uracil DNA glycosylase, transition-state inhibitor, 1-azadeoxyribose, crystal structure http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve& db=PubMed&list_uids=14580190&dopt=Abstract 1. Bakshi RP, Shapiro
TA. DNA topoisomerases as targets for antiprotozoal therapy. Mini Rev
Med Chem 2003;6:597-608. 2. Davies A, Kalb S, Liang B, Aldrich CJ, Lemonnier
FA, Jiang H, Cotter RJ, Soloski MJ. A peptide from heat shock protein
60 is the dominant peptide bound to Qa-1 in the absence of the MHC class
1a leader sequence peptide Qdm. J Immunol 2003;170:5027-5033. 3. Moyer SC, Von Seggern CE, Cotter RJ. Fragmentation
of cationized phosphotyrosine containing peptides by atmospheric pressure
MALDI/ion trap mass spectrometry. J Am Soc Mass Spectrom 2003;14:581-592. 4. Nenortas E, Kulikowicz T, Burri C, Shapiro TA.
Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions.
Antimicrob Agents Chemother 2003;47:3015-3017. 5. Violin JD, Zhang J, Tsien, RY, Newton,AC. A genetically
encoded fluorescent reporter reveals oscillatory phosphorylation by protein
kinase C. J Cell Biol 2003;161:899-909. 6. Von Seggern CE, Cotter RJ. Fragmentation studies
of non-covalent sugar-sugar complexes by infrared atmospheric pressure
MALDI. J Am Soc Mass Spectrom 2003;14:1158-1165. 7. Von Seggern CE, Moyer SC, Cotter RJ. Liquid infrared
atmospheric pressure MALDI/ion trap mass spectrometry of sialylated oligosaccharides.
Annal Chem 2003;75:3212-3218. 1. Dimick JB, Swoboda
S, Talamini MA, Pelz RK, Hendrix CW, Lipsett PA. Risk of colonization
of central venous catheters: catheters for total parenteral nutrition
vs other catheters. Am J Crit Care 2003;4:328-335. 2. Zheng W, Cole PA. Novel bisubstrate analog inhibitors
of serotoninn-acetyltransferase: The importance of being neutral. Bioorg
Chem 2003;31:398-411. 1. Cebrat M, Kim CM,
Thompson PR, Daugherty M, Cole PA. Synthesis and analysis of potential
prodrugs of coenzyme A analogs for the inhibition of histone acetyltransferase
p300. Bioorg Med Chem 2003;11:3307-3313. 2. Cole PA, Courtney AD, Zhang Z, Qiao Y, Lu W,
Williams DM. Chemical approaches to reversible protein phosphorylation.
Acc Chem Res 2003;36:444-452. 3. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V,
Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation
of Tat defines a cyclin T1-independent step in HIV transactivation. Mol
Cell 2003;12:167-176. 4. Stivers JT, Jiang YL. A mechanistic perspective
on the chemistry of DNA repair glycosylases. Chem Rev 2003;103:2729-2759. 1. Bodley AL, Chakraborty
AK, Xie S, Burri C, Shapiro TA. An unusual type IB topoisomerase from
African trypanosomes. Proc Natl Acad Sci USA 2003;100(13):7539-7544. 2. Kwon K, Cao C, Stivers JT. A novel "zinc
snap" motif conveys structural stability to 3-methyladenine DNA glycosylase
I. J Biol Chem 2003;278(21):19442–6. 3. Moyer SC, Von Seggern CE, Cotter RJ. Fragmentation
of cationized phosphotyrosine containing peptides by atmospheric pressure
MALDI/Ion trap mass spectrometry. JASMS 2003;14:581-92. 4. Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik
K, Xie S, Shapiro TA. Orally active, antimalarial, anticancer, artemisinin-derived
trioxane dimmers with high stability and efficacy. J Med Chem 2003; 46(6):1060-5. 5. Rajagopalan P, Pelz RK, Lipsett PA, Swoboda SM,
Rinaldi MG, Hendrix CW. Enteral fluconazole population pharmacokinetics
in patients in the surgical intensive care unit. Pharmacotherapy 2003;
23(5):592-602. 6. Scheibner KA, Zhang Z, Cole P A. Merging FRET
and expressed protein ligation to analyze protein-protein interactions.
Annal Biochem 2003;317:226-32. 7. Stivers JT, Jiang YL. A mechanistic perspective
on the chemistry of DNA repair glycosylases. Chem Rev 2003;103(7):272-60. 8. Washington CB, Flexner C, Sheiner LB, Rosenkranz
SL, Segal Y, Aberg JA, Blaschke TF. Effect of simultaneous versus staggered
dosing on pharmacokinetic interactions of protease inhibitors. Clin Pharmacol
Ther 200;73(5):406-16. 1. Cotter RJ, English RD, Warscheid B, Hardy A,
Gardner BD. Miniaturized time-of-flight mass spectrometers for bioagent
detection and identification. J Mass Spectrom Soc Japan 2003; 51:36-41. 2. Georges SA, Giebler HA, Cole PA, Luger K, Laybourn
PJ, Nyborg JK. Tax recruitment of CBP/p300, via the KIX domain, reveals
a potent requirement for acetyltransferase activity that is chromatin
dependent and histone tail independent. Mol Cell Biol 2003; 23(10): 3392-404.
3. Hamzeh FM, Benson C, Gerber J, Currier J, McCrea
H, Deutsch P, Ruan P, Wu H, Lee J, Flexner C. Steady-state phamacokinetic
interaction of modified-dose indinavir and rifabutin. Clin Pharmacol Ther
2003; 73 (3): 159-69. 4. Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen
L. Sequence-specific recruitment of transcriptional co-repressor Cabin1
by myocyte enhancer factor-2. Nature 2003 Apr 17; 422 (6933): 730-4. 5. Huang ZQ, Li J, Sachs LM, Cole PA, Wong J. A
role for cofactor-cofactor and cofactor-histone interactions in targeting
p300, SWI/SNF and mediator for transcription. EMBO J 2003 May 1; 22 (9):
2146-2155. 6. Jackson JB, Barnett S, Piwowar-Manning
E, Apuzzo L, Raines C, Hendrix C, Hamzeh F, Gallant J. A phase I/II study
of nevirapine for pre-exposureprophylaxis of HIV-1 transmission in uninfected
subjects at high risk. AIDS 2003 Mar 7; 17 (4): 547-53. 7. Jiang YL, Stivers JT. Epimerization of aromatic
C-nucleosides with electron-withdrawing substituents with trifluoroacetic
acid-benzenesulfonic acid using mild conditions. Tetrahedron Lett 2003;
44: 4051-4055. 8. Kwon K, Jiang Y L, Stivers JT Rational engineering
of a DNA glycosylase specific for unnatural cytosine: pyrene base pairs.
Chem and Biol 2003; 10: 351-359. 9. Lee KC, Li J, Cole PA, Wong J, Kraus WL. Transcriptional
activation by thyroid hormone receptor-beta involves chromatin remodeling,
histone acetylation, and synergisticstimulation by p300 and steroid receptor
coactivators. Mol Endocrinol 2003; 17 (5): 908-22. 10. Lu W, Shen K, Cole PA. Chemical dissection of
the effects of tyrosine phosphorylation of SHP-2. Biochemistry 2003 May
13; 42 (18): 5461-8. 11. Lu Y, Raviprakash K, Leao IC, Chikhlikar PR,
Ewing D, Anwar A, Chougnet C, Murphy G, Hayes CG, August JT, Marques ETA.
Dengue 2 PreM-E/LAMP chimera targeted to the MHC class II compartment
elicits long-lasting neutralizing antibodies. Vaccine 2003; 21: 2187-2198. 1. Kwak, MK, Wakabayashi,
N, Itoh, K, Motohashi, H, Yamamoto, M and Kensler, TW. Modulation of gene
expression by cancer chemopreventive dithiolethiones through the Keap1-
and Nrf2 pathway: Identification of novel gene clusters for cell survival.
J Biol Chem 2003; 278: 8135-8145. 2. Que-Gewirth, NLS, Karbarz, MJ, Kalb, SR, Cotter,
RJ and Raetz, CRH. Origin of the 2-aminogluconante Unit in Rhizobium Leguminosarum
Lipid A: Expression cloning of the Outer Membrane Oxidase LpxQ. J. Biol.
Chem. 2003; 278:12120-12129. 3. Ramos-Gomez M, Dolan PM, Itoh K, Yamamoto M,
Kensler TW. Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA
adducts and tumor yield in mice. Carcinogenesis 2003; 24:461-467. 1. Bakshi R, Shapiro TA. DNA topoisomerases as targets
for antiprotozoal therapy. Mini-Reviews in Medicinal Chemistry. 2003;
in press 2. English RD, Cotter RJ. A miniaturized matrix-assisted
laser desorption/ionization time of flight mass spectrometer with mass-correlated
acceleration focusing, J Mass Spectrom. 2003; 38: 296-304 3. Jiang YL, Ichikawa Y, Song F, Stivers JT. Powering
DNA repair through substrate electrostatic interactions. Biochem. 2003;
42,1922-1929 4. Jiang YL, Stivers JT. Efficient epimerization
of pyrene and other aromatic C-nucleosides with trifluoroacetic acid in
dichloromethane tetrahedron. Lett. 2003; 44, 85-88 5. Kobrinsky E, Schwartz E, Abernethy DR, Soldatov
NM. Voltage-gated mobility of the Ca++ Channel cytoplasmic tails and its
regulatory role. J Biol Chem. 2003; 278:5021-5028. 6. Kwon K, Cao C, Stivers JT. A novel "zinc
snap" motif conveys structural stability to 3-methyladenine DNA glycosylase
I. J Biol Chem. 2003; in press 7. Mitch WE, Walser M. Nutritional therapy in renal
disease. In: The Kidney, Volume II, 7th edition, B.M. Brenner, Editor.
W.B. Saunders. 2003; in press 8. Moyer SC, Marzilli LA, Woods AS, Laiko VV, Doroshenko
VM, Cotter RJ. Atmospheric pressure matrix-assisted laser desorption/ionization
(AP MALDI) on a quadrupole ion trap mass spectrometer. Int J Mass Spectrom.
2003; 226:133-150 9. Walser M with Thorpe B. How to Beat Kidney Disease
and Avoid Dialysis. John Wiley & Sons. 2003; in press 10. Zhang Z, Shen K, Lu W, Cole PA. The Role of
C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored
via expressed protein ligation. J Biol Chem. 2003; 278: 4668-4674.
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