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January 2017
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Pharmacology and Molecular Sciences Archives

1. Cox PM and Bumpus NN. Structure-activity studies reveal the oxazinone ring is a determinant of cytochrome P450 2B6 activity toward efavirenz. ACS Med Chem Lett. 2014 Sep 4;5(10):1156-1161.
Key words: cytochromes P450; drug metabolism; mass spectrometry; efavirenz; structure-activity
http://www.ncbi.nlm.nih.gov/pubmed/25309681

2. Lu Y, Fuchs EJ, Hendrix CW, Bumpus NN. CYP3A5 Genotype Impacts Maraviroc Concentrations in Healthy Volunteers. Drug Metab Dispos. 2014 Nov;42(11):1796-802.
Key words: Pharmacogenetics, maraviroc, HIV, drug metabolism and pharmacokinetics
http://www.ncbi.nlm.nih.gov/pubmed/25117426

3. Prendergast J, Umanah GK, Yoo SW, Lagerlöf O, Motari MG, Cole RN, Huganir RL, Dawson TM, Dawson VL, Schnaar RL. Ganglioside regulation of AMPA receptor trafficking. J Neurosci. 2014 Sep 24;34(39):13246-58.
Key words: AMPA receptor, ganglioside, GluR2, N-ethylmaleimide-sensitive factor, Nicalin; Thorase
http://www.ncbi.nlm.nih.gov/pubmed/25253868

1. Cieniewicz AM, Moreland L, Ringel AE, Mackintosh SG, Raman A, Gilbert TM, Wolberger C, Tackett AJ, Taverna SD. The bromodomain of Gcn5 regulates site-specificity of lysine acetylation on histone H3. Molecular and Cellular Proteomics. 2014 Aug 8. pii: mcp.M114.038174. [Epub ahead of print]
Key words: Gcn5, histone, acetylation, bromodomain, chromatin

http://www.ncbi.nlm.nih.gov/pubmed/25106422

2. Gilbert TM, McDaniel SL, Byrum SD, Cades JA, Dancy BCR, Wade H, Tackett AJ, Strahl BD, Taverna SD. An H3K36me3 binding PWWP protein targets the NuA3 acetyltransferase complex to coordinate transcriptional elongation at coding regions. Molecular and Cellular Proteomics. 2014 Aug 6. pii: mcp.M114.038224. [Epub ahead of print]
Key words: Histone, transcription, acetylation, methylation, chromatin
http://www.ncbi.nlm.nih.gov/pubmed/25104842

3. Papazyan R, Voronina E, Chapman JR, Luperchio TR, Gilbert TM, Meier E, Mackintosh SG, Shabanowitz J, Tackett AJ, Reddy KL, Coyne RS, Hunt DF, Liu Y, Taverna SD. Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.
eLife. 2014 Aug 26;3:e02996. doi: 10.7554/eLife.02996
Key words: Histone, DNA damage, methylation, meiosis, genome integrity
http://www.ncbi.nlm.nih.gov/pubmed/25161194

4. Waldrip ZJ, Byrum SD, Storey A, Gao J, Byrd AK, Mackintosh SG, Wahls WP, Taverna SD, Raney KD, Tackett AJ. A CRISPR-based approach for proteomic analysis of a single genomic locus. Epigenetics. 2014; 9(9). [Epub ahead of print]
Key words: Transcription, histone post-translational modifications, epigenetics, CRISPR, mass spectrometry
http://www.ncbi.nlm.nih.gov/pubmed/25147920

1. Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J. Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. Elife. 2014 Jul 23:e03765. doi: 10.7554/eLife.03765. [Epub ahead of print]
Key words: calcium; oscillation; FRET; biosensor; live-cell imaging
http://www.ncbi.nlm.nih.gov/pubmed/25056880

1. Brammer Basta LA, Patel H, Kakalis L, Jordan F, Freel Meyers CL. Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2?-lactylthiamin diphosphate. FEBS J. 2014 June;281(12):2820-37.
Key words: CD; DXP synthase; enzymology; protein fluorescence; thiamin

http://www.ncbi.nlm.nih.gov/pubmed/24767541

1. Tullman JA, Harmon M-E, Delannoy M, Gibson W. Recovery of an HMWP/hmwBP (pUL48/pUL47) complex from virions of human cytomegalovirus: subunit interactions, oligomers composition, deubiquitylase activity. J Virology. 2014 May 14. pii: JVI.00971-14. [Epub ahead of print.]
Key words: Cytomegalovirus, herpesvirus, protein-protein interactions, ubiquitin, deubiquitylase, virus structure
http://www.ncbi.nlm.nih.gov/pubmed/24829352

1. Calcaterra NE, Barrow JC. Classics in Chemical Neuroscience: Diazepam (Valium). ACS Chem. Neurosci. 2014 Apr 16;5(4):253-60.
Key words: Diazepam, Valium, benzodiazepine, GABA, anxiety, hypnotic, sedative
http://www.ncbi.nlm.nih.gov/pubmed/24552479

1. Hersman EM, Bumpus NN. A targeted proteomics approach for profiling murine cytochrome P450 expression. J Pharmacol Exp Ther. 2014 May;349(2):221-8.
Key words: cytochrome P450; mass spectrometry; drug metabolism
http://www.ncbi.nlm.nih.gov/pubmed/24594750

1. Webster MR, Kamat C, Connis N, Zhao M, Weeraratna AT, Rudek MA, Hann CL, Freel Meyers CL. Bisphosphonamidate clodronate prodrug exhibits selective cytototxic activity against melanoma cell lines. Mol Cancer Ther. 2014 Feb;13(2):297-306.
Key words: prodrug, bisphosphonate, melanoma, clodronate
http://www.ncbi.nlm.nih.gov/pubmed/24310621

1. Kiwamoto T, Brummet ME, Wu F, Motari MG, Smith DF, Schnaar RL, Zhu Z, Bochner BS. Mice deficient in the St3gal3 gene product ?2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. J Allergy Clin Immunol. 2014 Jan;133(1):240-247.
Key words: asthma, airway, inflammation, eosinophil, lung
http://www.ncbi.nlm.nih.gov/pubmed/23830412

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