Pharmacology and Molecular Sciences Archives

2013
02/13

1. Smith J, Vierling RJ, Freel Meyers CL. Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates. MedChemComm. 2012; 3(1): 65-67.
Key words: isoprenoid biosynthesis, DXP synthase, anti-infectives, acetylphosphonate
http://www.ncbi.nlm.nih.gov/pubmed/23326631

01/13

1. Patel H, Nemeria N, Brammer L, Freel Meyers C, Jordan F. Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate. J Am Chem Soc 2012;134:18374-79.
Key words: thiamin diphosphate, isoprenoid biosynthesis, anti-infectives
http://www.ncbi.nlm.nih.gov/pubmed/23072514

2012
10/12

1. Mountney A, Zahner MR, Sturgill ER, Riley CJ, Aston JW, Oudega M, Schramm LP, Hurtado A, Schnaar RL. Sialidase, chondroitinase ABC and combination therapy after spinal cord contusion injury. J Neurotrauma. 2012 Aug 31. [Epub ahead of print]
Key words: Spinal cord injury; axon regeneration; ganglioside; motor behavior; serotonergic axons
http://www.ncbi.nlm.nih.gov/pubmed/22934782

2. Shim JS, Rao R, Beebe K, Neckers L, Han I, Nahta R, Liu JO. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. J Natl Cancer Inst. 2012 Oct 5. [Epub ahead of print]
Key words include: Nelfinavir, Johns Hopkins Drug Library, Her2, breast cancer, and drug resistance
http://www.ncbi.nlm.nih.gov/pubmed/23042933

3. Sturgill ER, Aoki K, Lopez PH, Colacurcio D, Vajn K, Lorenzini I, Majic S, Yang WH, Heffer M, Tiemeyer M, Marth JD, Schnaar RL. Biosynthesis of the major brain gangliosides GD1a and GT1b. Glycobiology. 2012 Oct;22(10):1289-301. Epub 2012 Jun 26.
Key words: Brain, ganglioside, myelin, sialic acid, sialyltransferase
http://www.ncbi.nlm.nih.gov/pubmed/22735313

08/12

1. Byrum SD, Raman A, Taverna SD, Tackett AJ. ChAP-MS: A method for identification of proteins and histone posttranslational modifications at a single genomic locus. Cell Reports. 2012 July 26;2(1):198-205.
Key words: Histone, chromatin, affinity purification, transcription, mass spectrometry
http://www.ncbi.nlm.nih.gov/pubmed/22840409

2. Jung KO, Khan AM, Tan BY, Hu Y, Simon GG, Nascimento EJ, Lemonnier F, Brusic V, Miotto O, Tan TW, Marques ET, Dhalia R, Salmon J, August JT. West nile virus T-cell ligand sequences shared with other flaviviruses: a multitude of variant sequences as potential altered Peptide ligands. J Virol. 2012 July; 86(14):7616-7624.
Key words: West Nile virus, T-cell ligand, flaviviruses, altered peptide ligands, immune cross-reactivity
http://www.ncbi.nlm.nih.gov/pubmed/22573867

07/12

1. Barrow, JC. Inhibitors of catechol-o-methyltransferase. CNS Neurol Disord Drug Targets, 2012 May;11(3):324-332.
Key words: Catechol-O-methyltransferase; COMT; dopamine; L-DOPA; Parkinson's disease
http://www.ncbi.nlm.nih.gov/pubmed/22483290

2. Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ. Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta. 2012 May;1822(5):753-83.
Key words: Nrf2, Keap1, stress, sulforaphane, hormesis
http://www.ncbi.nlm.nih.gov/pubmed/22108204

3. Dedecker P, Mo GCH, Dertinger T, Zhang J. A widely accessible method for superresolution fluorescence imaging of living systems. Proc. Natl. Acad. Sci. USA. 2012 Jul 3;109(27):10909-10914. [Epub ahead of print]
Key words: subdiffraction-limit, two-color imaging, membrane rafts
http://www.ncbi.nlm.nih.gov/pubmed/22711840

4. Dinkova-Kostova AT, Kostov R. Glucosinolates and isothiocyanates in health and disease. Trends Mol Med. 2012 Jun;18(6):337-47.
Key words: NQO1, sulforaphane, phenethylisothiocyanate, cancer, neurodegenerative disease
http://www.ncbi.nlm.nih.gov/pubmed/22578879

5. Ibbotson SH, Dawe RS, Dinkova-Kostova AT, Weidlich S, Farr PM, Ferguson J, Wolf CR, Smith G. Glutathione S-transferase genotype is associated with sensitivity to psoralen-UVA (PUVA) photochemotherapy. Br J Dermatol. 2012; 166: 380-388.
Key words: GST, psoralen, UVA, 8-MOP, photochemotherapy
http://www.ncbi.nlm.nih.gov/pubmed/21967523

6. Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy. Cancer Prev Res (Phila). 2012 Jul;5(7):973-81.
Key words: cyanoenone, Nrf2, NQO1, skin cancer, ultraviolet radiation
http://www.ncbi.nlm.nih.gov/pubmed/22659146

7. Zheng S, Laxmi Y R S, David E, Dinkova-Kostova AT, Shiavoni KH, Ren Y, Zheng Y, Trevino I, Bumeister R, Ojima I, Wigley WC, Bliska J, Mierke DF, Honda T. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents. J Med Chem. 2012 May 24; 55(10): 4837-4846.
Key words: Keap1, Michael acceptor, NQO1, iNOS, cyanoenone
http://www.ncbi.nlm.nih.gov/pubmed/22533790

03/12

1. Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora. Cancer Prev Res (Phila). 2012 Mar 13. [Epub ahead of print].
Key words: isothiocyanates, gastrointestinal microflora, glucosinolates, chemoprotection, crucifers
http://www.ncbi.nlm.nih.gov/pubmed/22318753

2. Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA. N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nat Neurosci. 2012 Feb 26. [Epub ahead of print].
Key words: Stroke, Apoptosis, Neuron, ABT-737, Knockin mice
http://www.ncbi.nlm.nih.gov/pubmed/22366758

3. Sample V, Dipilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J. Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nat Chem Biol 2012 Feb 26. [Epub ahead of print]
Key words: cAMP; spatiotemporal control; fluorescence imaging; mathematic modeling; functional nuclear PKA
http://www.ncbi.nlm.nih.gov/pubmed/22366721

2011
12/11

1. Hostetler ED, Sanabria-Bohórquez S, Fan H, Zeng Z, Gammage L, Miller P, O'Malley S, Connolly B, Mulhearn J, Harrison ST, Wolkenberg SE, Barrow JC, Williams DL Jr, Hargreaves RJ, Sur C, Cook JJ. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nuclear Medicine and Biology. 2011; 38: 1193-1203.
Key words: Alzheimer's disease; Amyloid plaque, PET; Monkey; Fluorine-18; White matter
http://www.ncbi.nlm.nih.gov/pubmed/21741254

11/11

1. Li R, Zhu J, Xie Z, Liao G, Liu J, Chen MR, Hu S, Woodard C, Lin J, Taverna SD, Desai P, Ambinder RF, Hayward GS, Qian J, Zhu H, Hayward SD. Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe 2011; 10(4):390-400.
Key words: pathogen-host interaction, viral kinase, TIP60, herpesvirus, virus replication
http://www.ncbi.nlm.nih.gov/pubmed/22018239

10/11

1. Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA. Bcl-x(L) regulates metabolic efficiency of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase. Nat Cell Biol. 2011 Sep 18; 13(10):1224-1233.
Key words: Bcl-xL, mitochondria, energetics, neurons, ATP synthase
http://www.ncbi.nlm.nih.gov/pubmed/21926988

2. Brammer LA, Smith JM, Wade H, Freel Meyers C. 1-Deoxy-D-Xylulose 5-phosphate synthase: A novel random sequential mechanism in thiamine Diphosphate-dependent enzymology. J Biol Chem. 2011 Oct 21; 286(42):36522-31.
Key words: mthylerythritol phosphate pathway, isoprenoid biosynthesis, deoxy-D-xylulose 5-phosphate synthase
http://www.ncbi.nlm.nih.gov/pubmed/21878632

3. Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol. 2011 Oct 17;195(2):263-76.
Key words: Bcl-xL, mitochondria, neurons, apoptosis, ATP synthase
http://www.ncbi.nlm.nih.gov/pubmed/21987637

4. Webster MR, Zhao M, Rudek MA, Hann CL, Freel Meyers CL. Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells. J Med Chem. 2011 Oct 13;54(19):6647-56.
Key words: bisphosphonate, bisphosphonamidate prodrug, clodronate
http://www.ncbi.nlm.nih.gov/pubmed/21863853

09/11

1. Healy ZR, Liu H, Holtzclaw WD, Talalay P. Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: A potential biomarker for anti-inflammatory intervention. Cancer Epidemiol Biomarkers Prev. 2011 July;20(7): 1516-1523.
Key words: Macrophage migration inhibitory factor (MIF), Sulforaphane, Biomarker, Anti-inflammatory activity
http://www.ncbi.nlm.nih.gov/pubmed/21602309

2. Lu J-Y, Lin Y-Y, Sheu J-C, Wu J-T, Lee F-J, Chen Y, Lin M-I, Chiang F-T, Tai T-Y, Berger SL, Zhao Y, Tsai K-S, Zhu H, Chuang L-M, Boeke JD. Acetylation of AMPK controls intrinsic aging independently of caloric restriction. Cell. 2011 Sept; 146(6): 969-979.
Key words: Intrinsic yeast ageing, Sip2 acetylation, Snf1 inhibition, Sch9, and NuA4 complex
http://www.ncbi.nlm.nih.gov/pubmed/21906795

04/11

1. Baird L, Dinkova-Kostova AT. The cytoprotective role of the Keap1/Nrf2/ARE pathway. Arch Toxicol. 2011 Apr; 85: 241-272.
Key words: Keap1, Nrf2, ARE, Cytoprotective enzymes, Phase 2 inducer
http://www.ncbi.nlm.nih.gov/pubmed/21365312

2. Honda T, Dinkova-Kostova AT, David E, Padegimas EM, Sundararajan C, Visnick M, Bumeister R; Wigley WC. Synthesis and biological evaluation of 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent. Bioorg Med Chem Lett. 2011 Apr; 21: 2188-2191.
Key words: Triterpene, Oleanolic acid, Acetylenicimidazole, iNOS inhibition, Induction of HO-1 and NQO1
http://www.ncbi.nlm.nih.gov/pubmed/21441026

3. Reger TS, Yang ZQ, Schlegel KAS, Shu Y, Mattern C, Cube R, Rittle KE, McGaughey GB, Hartman GD, Tang C, Ballard J, Kuo Y, Prueksaritanont T, Nuss CE, Doran SM, Fox SV, Garson SL, Li Y, Kraus RL, Uebele VN, Renger JJ, Barrow JC. Pyridyl amides as potent inhibitors of T-type calcium channels. Bioorg. Med. Chem. Lett. 2011 March; 21:1692-1696.
Key words: T-type, Calcium channel, epilepsy, sleep, medicinal chemistry
http://www.ncbi.nlm.nih.gov/pubmed/21316226

03/11

1. Blair LP, Avaritt NL, Huang R, Cole PA, Taverna SD, Tackett AJ. MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity. Epigenetics. 2011, Apr 1;6(4).
Key words: Histone, Epigenetics, Demethylation, LSD1, Mass Spectrometry
http://www.ncbi.nlm.nih.gov/pubmed/21273814

2. Enger PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Marlin D, Jacobson FLP, Munoz A, Ng D, Qian GS, Zhu YR, Chen TY, Botting NP, Zhang, Q, Fahey JW, Talalay P, Groopman JD, Kensler, TW. Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prevention Research. 2011;4(3) 384-395.
Key words: MIF (microphage migration inhibitory factor), RAW 264.7 cells, Nrf2, NQO1
http://www.ncbi.nlm.nih.gov/pubmed/21372038

3. Suganuma H, Fahey T., Bryan, KE, Healy ZR, Talalay P. Stimulation of phagocytosis by sulforaphane. Biochemical and Biophysical Research Communication. 2011;405:146-151.
Key words: sulforaphane, glucoraphanin, broccoli sprouts, clinical trail, aftlatoxin
http://www.ncbi.nlm.nih.gov/pubmed/21219867

4. Xiao Y, Rooker D, You Q, Meyers CL, Liu P. IspG-catalyzed positional isotopic exchange in methylerythritol cyclodiphosphate of the deoxyxylulose phosphate pathway: mechanistic implications. ChemBioChem 2011;12:527-530.
Key words: DOXP pathway, MEP pathway, non-mammalian isoprenoid biosynthesis, IspG
No PMID available

01/11

1. Lopez PH, Ahmad AS, Mehta NR, Toner M, Rowland EA, Zhang J, Doré S, Schnaar RL. Myelin-associated glycoprotein protects neurons from excitotoxicity. J Neurochem. 2011 Jan 7;10(1111) 1471-4159. [Epub ahead of print]
Key words: Stroke, seizure, myelin, neuroprotection, hippocampal neurons
http://www.ncbi.nlm.nih.gov/pubmed/21214567

2. Ni Q, Ganesan A, Aye-Han N, Gao X, Allen MD, Levchenko A, and Zhang J. Signaling diversity of PKA via a Ca2+-cAMP-PKA oscillatory circuit. Nature Chem Biol. 2011 Jan;7(1):34-40.
Key words: signal transduction, oscillation, circuitry, fluorescence imaging, computational modeling
http://www.ncbi.nlm.nih.gov/pubmed/21102470

2010
10/10

1. Xiao Y, Nyland RL II, Freel Meyers CL, and Liu P. Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: synthesis from an epoxide and mechanisms. Chem. Commun2010 Oct 14;46(38):7220-2.
Key words: methylerythritol phosphate, non-mammalian isoprenoid biosynthesis, methylerythritol cyclodiphosphate
http://www.ncbi.nlm.nih.gov/pubmed/20820543

08/10

1. Wakabayash, N, Shin S, Slocum S, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. Regulation of Notch1 signaling by Nrf2: implications for tissue regeneration. Science Signaling 2010 Jul 13;3(130): ra52.
Key words: Nrf2, Notch1, antioxidant response element, liver regeneration
http://www.ncbi.nlm.nih.gov/pubmed/20628156

07/10
1. Mountney A, Zahner MR, Lorenzini I, Oudega M, Schramm LP, Schnaar RL. Sialidase enhances recovery from spinal cord contusion injury. Proc Natl Acad Sci USA 2010 Jun 7;107(25):11561-11566.
Key words: Spinal cord injury, axon regeneration, ganglioside, myelin, serotonergic axons
http://www.ncbi.nlm.nih.gov/pubmed/20534525

06/10

1. Ahn Y-H, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA. Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc Natl Acad Sci USA 2010 May 25;107(21):9590-9595.
Key words: sulforaphane, chemoprotection, natural product, isothiocyanate
http://www.ncbi.nlm.nih.gov/pubmed/20439747

2. Bensasson RV, Zoete V, Verthier G, Talalay P, Dinkova-Kostova AT. Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index. Chem Biol Interact 2010 July 30; 186; (2): 118-126.
Key words: electron affinity, inflammation, NAD(P)H-quinone oxidoreductase 1, quantum chemical calculations, structure-activity relationships
http://www.ncbi.nlm.nih.gov/pubmed/20433811

3. Hartman AL, Zheng X, Bergbower E, Kennedy M, Hardwick JM. Seizure tests distinguish intermittent fasting from the ketogenic diet . Epilepsia 2010 April 30. [Epub ahead of print].
Key words: ketogenic diet, intermittent fasting, epilepsy, 6 Hz test, kainic acid
http://www.ncbi.nlm.nih.gov/pubmed/20477852

4. Majumdar, A, Sun, Y, Shah, M, Freel Meyers, CL. Versatile 1H-31P-31P COSY 2D NMR techniques for the characterization of polyphosphorylated small molecules. J Org Chem 2010 May 21;75(10):3214-3223.
Key words: diphosphate, bisphosphonate, correlation spectroscopy
http://www.ncbi.nlm.nih.gov/pubmed/20408590

5. Mountney A, Zahner MR, Lorenzini I, Oudega M, Schramm LP, Schnaar RL. Sialidase enhances recovery from spinal cord contusion injury. Proc Natl Acad Sci USA 2010 Jun 22;107(25):11561-6.
Key words: Spinal cord injury, axon regeneration, ganglioside, myelin, serotonergic axons
http://www.ncbi.nlm.nih.gov/pubmed/20534525

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