Pharmacology and Molecular Sciences Archives 1. Smith J, Vierling RJ, Freel Meyers CL. Selective
inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates.
MedChemComm. 2012; 3(1): 65-67. 1. Patel H, Nemeria N, Brammer L, Freel Meyers
C, Jordan F. Observation of thiamin-bound intermediates and microscopic
rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate
synthase: 600-fold rate acceleration of pyruvate decarboxylation by
D-glyceraldehyde-3-phosphate. J Am Chem Soc 2012;134:18374-79. 1. Mountney A, Zahner MR, Sturgill ER, Riley CJ,
Aston JW, Oudega M, Schramm LP, Hurtado A, Schnaar RL. Sialidase, chondroitinase
ABC and combination therapy after spinal cord contusion injury. J Neurotrauma.
2012 Aug 31. [Epub ahead of print] 1. Byrum SD, Raman
A, Taverna SD, Tackett AJ. ChAP-MS: A method for identification of proteins
and histone posttranslational modifications at a single genomic locus.
Cell Reports. 2012 July 26;2(1):198-205. 1. Barrow, JC. Inhibitors
of catechol-o-methyltransferase. CNS Neurol Disord Drug Targets, 2012
May;11(3):324-332. 4. Dinkova-Kostova AT, Kostov R. Glucosinolates
and isothiocyanates in health and disease. Trends Mol Med. 2012 Jun;18(6):337-47.
5. Ibbotson SH, Dawe RS, Dinkova-Kostova AT, Weidlich
S, Farr PM, Ferguson J, Wolf CR, Smith G. Glutathione S-transferase
genotype is associated with sensitivity to psoralen-UVA (PUVA) photochemotherapy.
Br J Dermatol. 2012; 166: 380-388. 7. Zheng S, Laxmi Y R S, David E, Dinkova-Kostova
AT, Shiavoni KH, Ren Y, Zheng Y, Trevino I, Bumeister R, Ojima I, Wigley
WC, Bliska J, Mierke DF, Honda T. Synthesis, chemical reactivity as
Michael acceptors, and biological potency of monocyclic cyanoenones,
novel and highly potent anti-inflammatory and cytoprotective agents.
J Med Chem. 2012 May 24; 55(10): 4837-4846. 1. Fahey JW, Wehage
SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Protection
of humans by plant glucosinolates: efficiency of conversion of glucosinolates
to isothiocyanates by the gastrointestinal microflora. Cancer Prev Res
(Phila). 2012 Mar 13. [Epub ahead of print]. 2. Ofengeim D, Chen YB, Miyawaki T, Li H,
Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman
JA, Hardwick JM, Zukin RS, Jonas EA. N-terminally cleaved Bcl-xL mediates
ischemia-induced neuronal death. Nat Neurosci. 2012 Feb 26. [Epub ahead
of print]. 1. Hostetler ED, Sanabria-Bohórquez S,
Fan H, Zeng Z, Gammage L, Miller P, O'Malley S, Connolly B, Mulhearn
J, Harrison ST, Wolkenberg SE, Barrow JC, Williams DL Jr, Hargreaves
RJ, Sur C, Cook JJ. [18F]Fluoroazabenzoxazoles as potential amyloid
plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.
Nuclear Medicine and Biology. 2011; 38: 1193-1203. 1. Li R, Zhu J,
Xie Z, Liao G, Liu J, Chen MR, Hu S, Woodard C, Lin J, Taverna SD, Desai
P, Ambinder RF, Hayward GS, Qian J, Zhu H, Hayward SD. Conserved herpesvirus
kinases target the DNA damage response pathway and TIP60 histone acetyltransferase
to promote virus replication. Cell Host Microbe 2011; 10(4):390-400. 1. Alavian KN, Li H,
Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty
B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore
GC, Smith PJ, Hardwick JM, Jonas EA. Bcl-x(L) regulates metabolic efficiency
of neurons through interaction with the mitochondrial F(1)F(O) ATP synthase.
Nat Cell Biol. 2011 Sep 18; 13(10):1224-1233. 2. Brammer LA, Smith JM, Wade H, Freel Meyers
C. 1-Deoxy-D-Xylulose 5-phosphate synthase: A novel random sequential
mechanism in thiamine Diphosphate-dependent enzymology. J Biol Chem.
2011 Oct 21; 286(42):36522-31. 3. Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery
JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda
FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick
JM. Bcl-xL regulates mitochondrial energetics by stabilizing the inner
membrane potential. J Cell Biol. 2011 Oct 17;195(2):263-76. 4. Webster MR, Zhao M, Rudek MA, Hann CL, Freel
Meyers CL. Bisphosphonamidate clodronate prodrug exhibits potent anticancer
activity in non-small-cell lung cancer cells. J Med Chem. 2011 Oct 13;54(19):6647-56. 1. Healy ZR, Liu H,
Holtzclaw WD, Talalay P. Inactivation of tautomerase activity of macrophage
migration inhibitory factor by sulforaphane: A potential biomarker for
anti-inflammatory intervention. Cancer Epidemiol Biomarkers Prev. 2011
July;20(7): 1516-1523. 2. Lu J-Y, Lin Y-Y, Sheu J-C, Wu J-T, Lee F-J,
Chen Y, Lin M-I, Chiang F-T, Tai T-Y, Berger SL, Zhao Y, Tsai K-S, Zhu
H, Chuang L-M, Boeke JD. Acetylation of AMPK controls intrinsic aging
independently of caloric restriction. Cell. 2011 Sept; 146(6): 969-979. 1. Baird L, Dinkova-Kostova AT. The cytoprotective
role of the Keap1/Nrf2/ARE pathway. Arch Toxicol. 2011 Apr; 85: 241-272. 1. Blair LP, Avaritt
NL, Huang R, Cole PA, Taverna SD, Tackett AJ. MassSQUIRM: An assay for
quantitative measurement of lysine demethylase activity. Epigenetics.
2011, Apr 1;6(4). 3. Suganuma H, Fahey T., Bryan, KE, Healy ZR,
Talalay P. Stimulation of phagocytosis by sulforaphane. Biochemical
and Biophysical Research Communication. 2011;405:146-151. 4. Xiao Y, Rooker D, You Q, Meyers CL, Liu P.
IspG-catalyzed positional isotopic exchange in methylerythritol cyclodiphosphate
of the deoxyxylulose phosphate pathway: mechanistic implications. ChemBioChem
2011;12:527-530. 1. Lopez PH, Ahmad AS, Mehta NR, Toner M, Rowland
EA, Zhang J, Doré S, Schnaar RL. Myelin-associated glycoprotein
protects neurons from excitotoxicity. J Neurochem. 2011 Jan 7;10(1111)
1471-4159. [Epub ahead of print] 2. Ni Q, Ganesan A, Aye-Han N, Gao X, Allen MD,
Levchenko A, and Zhang J. Signaling diversity of PKA via a Ca2+-cAMP-PKA
oscillatory circuit. Nature Chem Biol. 2011 Jan;7(1):34-40. 1. Xiao Y, Nyland RL II, Freel Meyers CL, and
Liu P. Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate
pathway: synthesis from an epoxide and mechanisms. Chem. Commun2010
Oct 14;46(38):7220-2. 1. Wakabayash, N, Shin S, Slocum S, Agoston ES,
Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. Regulation
of Notch1 signaling by Nrf2: implications for tissue regeneration. Science
Signaling 2010 Jul 13;3(130): ra52.
1. Ahn Y-H, Hwang Y,
Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova
AT, Talalay P, Cole PA. Electrophilic tuning of the chemoprotective
natural product sulforaphane. Proc Natl Acad Sci USA 2010 May 25;107(21):9590-9595. 3. Hartman AL, Zheng
X, Bergbower E, Kennedy M, Hardwick JM. Seizure tests distinguish intermittent
fasting from the ketogenic diet . Epilepsia 2010 April 30. [Epub ahead
of print]. 4. Majumdar, A, Sun,
Y, Shah, M, Freel Meyers, CL. Versatile 1H-31P-31P COSY 2D NMR techniques
for the characterization of polyphosphorylated small molecules. J Org
Chem 2010 May 21;75(10):3214-3223.
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