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July 2008
PUBLICATIONS - Back

Pharmacology and Molecular Sciences Archives

1. Dinkova-Kostova, AT, Jenkins, SN, Wehage, SL, Huso, DL, Benedict, AL, Stephenson, KK, Fahey, JW, Liu, H, Liby, KT, Honda, T, Gribble, GW, Sporn, MB, Talalay, PA. Dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice. Biochem Biophys Res Commun 2008 Mar 21;367(4):859-65.
Key words: 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile; Heme oxygenase 1; NQO1; SKH-1 hairless mouse
http://www.ncbi.nlm.nih.gov/pubmed/18206646?ordinalpos=3&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed

1. Chen CS, Korobkova E, Chen H, Zhu J, Jian X, Tao SC, He C, Zhu H. A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Nat Methods 2008:5(1);69-74.
Key words: Proteome chip, high-throughput protein purification, E. coli, and DNA damage
http://www.ncbi.nlm.nih.gov/pubmed/18084297?ordinalpos=4&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

2. Lu JY, Lin YY, Qian J, Tao SC, Zhu J, Pickart C, Zhu H. Functional dissection of a HECT ubiquitin E3 ligase. Mol Cell Proteomics 2008:7(1);35-45.
Key words: Ubiquitin, E3 ligase, proteome chip, Rsp5, and HECT
http://www.ncbi.nlm.nih.gov/pubmed/17951556?ordinalpos=7&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Allen MD, Zhang J. A tunable FRET circuit for engineering fluorescent biosensors. Angew Chem Int Ed Engl 2008 January: 47(3);500-502.
Key words: FRET, biosensors, kinase, live-cell, methodology
http://www.ncbi.nlm.nih.gov/pubmed/18058965?ordinalpos=2&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

2. Ananthanarayanan B, Fosbrink M, Rahdar M, Zhang J. Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation. J Biol Chem 2007 December; 282(50): 36634-36641.
Key words: kinase, Akt, FRET, signaling, activation
http://www.ncbi.nlm.nih.gov/pubmed/17928291?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

3. Cordeiro MT, Silva AM, Brito CAA, Nascimento EJM, Magalhaes MCF, Guimaraes
GF, Lucena-Silva N, de Carvalho EMF, Marques ETA. Characterization of a
dengue patient cohort in Recife, Brazil. Am J Trop Med Hyg 2007 Dec:77(6);
1128-1134.
Key words: Dengue virus, epidemiology, diagnostic, clinical immunology and immunopathology
http://www.ncbi.nlm.nih.gov/pubmed/18165535?ordinalpos=1&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

1. Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS ONE 2007 Oct 10;2(10):e1007.
Key words: infection imaging, nucleosides, positron emission tomography, prosthesis infection
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17925855

2. Kerns ML, DePianto D, Dinkova-Kostova AT, Talalay P, Coulombe PA. Reprogramming of keratin biosysthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. Proc Natl Acad Sci USA 2007;104:14460-14465.
Key words: Gli2, keratin 14 null, keratin 17, NQ01, Nrf2
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17724334

3. Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci USA 2007;104:17500-17505.
Key words: erythema, nicotinamide:qunionone oxidoreductase 1, skin tumor, chemoprotection
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17956979

1. Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, Kensler TW. NRF2 modulates AHR signaling: influence on adipogenesis. Molec. Cell. Biol. 2007 Oct; 27 (20):7188-7197.
Key words: Nrf2, AhR, adipogenesis, chemoprevention, signaling
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17709388

2. Zhang Y, Bressler JP, Neal J, Lal B, Bhang H-E C, Laterra J, Pomper MG. ABCG2/BCRP expression modulates D-luciferin-based bioluminescence imaging. Cancer Research 2007 Oct 1;67 (19):9389-9397.
Key words: molecular imaging, ABC transporter, multidrug resistance, luciferase, small animal imaging
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17909048

1. Mehta NR, Lopez PH, Vyas AA, Schnaar RL. Gangliosides and Nogo receptors
independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells. J Biol Chem 2007 Sept 21;282:27875-27886.
Key words: axon, regeneration, sialidase, RhoA, p75NTR
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17640868

2. Whitmore CD, Hindsgaul O, Palcic MM, Schnaar RL, Dovichi NJ. Metabolic cytometry. Glycosphingolipid metabolism in single cells. Anal Chem 2007 Jul 15;79(14):5139-5142.
Key words: metabolomics, ganglioside, capillary electrophoresis, laser-induced fluorescence, zeptomole
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17567107

1. Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen M-SA, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 2007 July;28:1485-1490.
Key words: sulforaphane, chemoprevention, mammary tissue, quinine oxidoreductase, broccoli sprouts
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17347138

2. Liby K, Honda T, William CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB. Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities. Mol Cancer Ther 2007 Jul;6:2113-2119.
Key words: betulinic acid, nitric oxide synthase, phase 2 enzymes, chemoprevention, apoptosis
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17620440

1. Low W-K, Dang Y, Bhat S, Romo D, Liu JO. Substrate-dependent targeting of
eukaryotic translation initiation factor 4A by pateamine A: Negation of
domain-linker regulation of activity. Chemistry & Biology 2007 Jun;14:715-727.
Key words: pateamine, translation, eIF4A, RNA, proliferation
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&
TermToSearch=17584618

1. Zhu J, Gopinath K, Murali A, Yi G, Hayward SD, Zhu H, Kao C. RNA-binding proteins that inhibit RNA virus infection. Proc Natl Acad Sci USA 2007 Feb 27;104:3129-3134.
Key words: Brome mosaic virus, protein chip, RNA-protein interaction, SLD loop, infection
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17360619

1. Brignole EJ, Gibson W. Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: Maximal activity of pPR requires self-interaction through its scaffolding domain. J Virol 2007; Feb 7. [Epub ahead of print]
Key words: cytomegalovirus proteins, serine protease, assembling, self-interaction, enzyme activation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17287260

2. Fu DX, Tanhehco YC, Chen J, Foss CA, Fox JJ, Lemas V, Chong JM, Ambinder RF, Pomper MG. Virus-associated tumor imaging by indrruction of viral gene expression. Clin Cancer Res 2007;13:1453-1458.
Key words: epstein-barr virus, lytic induction, reporter gene, imaging, bortezomib, FIAU
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17332288

3. Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Nature 2007;445:433-436.
Key words: carabin, calcineurin, Ras, feedback inhibition, calcium signaling
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17230191

1. Chikhlikar P, de Arruda LB, Maciel M, Silvera P, Lewis MG, August JT, Marques ETA. DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in rhesus. PloS One 2006 Dec;1:e135.
Key words: HIV, vaccine, DNA, lysosome, mokey
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17205139

2. Jamieson HA, Hilmer SN, Cogger VC, Warren A, Cheluvappa R, Abernethy DR, Everitt AV, Fraser R, deCabo R, Le Couteur DG. Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp Gerontol 2007; Jan. 2, epub ahead of print.
Key words: dietary restriction, hepatic sinusoid, aging
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17204388

3. Loveland AN, Nguyen NJ, Brignole EJ, Gibson W. The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formatiion and virus production. J. Virol 2007 Jan;81:620-628.
Key words: cytomegalovirus proteins, capsid assembly, tetra-cysteine staining, HCMV UL80, protein-protein interactions
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17079329

4. Mager DE, Abernethy DR. Perspectives in pharmacology: Fast fourier and wavelet transforms in pharmacodynamics. J Pharmacol Exp Ther 2006; Dec. 1, epub ahead of print.
Key words: wavelets, pharmacodynamics, image analysis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17142645

5. Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll, DM, Liu JO. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Nature 2007 Jan; 445:433-436.
Key words: Carabin, calcineurin, Ras, calcium signaling, feedback inhibition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17230191

1. Collins S, Wolfraim LA, Drake CG, Horton MR, Powell JD. Cutting edge: transcription. J Immunol 2006 Dec 15;177 (12):8301-8305.
Key words: T cells, Egr, NAB2, IL-2 Co-activation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17142725

2. Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci USA 2006 Nov 28;103(48):18148-53.
Key words: methionine aminopeptidase 1, cell cycle, apoptosis. cancer and G2 phase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&listuids=1711429

1. Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao R-P, Abernethy DR. Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality 2006 Nov;18:822-827.
Key words: affinity chromatography, fenoterol, stereoisomer, beta-2 adrenergic agonist
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16917835

2. Shamay M, Krithivas A, Zhang J, Hayward SD. Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA. Proc Natl Acad Sci USA 2006 Sept;103:14554-14559.
Key words: virus induced epigenetic modification of host DNA
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16983096

3. Tao SC, Zhu H. Protein chip fabrication by capture of nascent polypeptides. Natl Biotechnol 2006 Oct;10:1253-1254.
Key words: protein chip, peptide chip, in vitro translation, ribosome display.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17013375

4. Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM. Atherosclerosis-related molecular alteration of the human Cav1.2 calcium channel a1C subunit. Proc Nat Acad Sci USA 2006 Nov ;103:17024-17029.
Key words: calcium channel, splice variant, atherosclerosis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=17071743

1. Wang J, Loveland AN, Kattenhorn LM, Ploegh HL, Gibson W. High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. J Virol 2006;80:6003-6012.
Key words: cytomegalovirus, ubiquitin, deubiquitinase, viral enzymes, protease
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
AbstractPlus&list_uids=16731939

1. Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault A. The sirtuins hst3 and hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Current Biology 2006;16:1280-1289.
Key words: histone, acetylation, sirtuins, mass spectrometry, MALDI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=
Abstract&list_uids=16815704

1. Hu X, Addlagatta A, Matthews BW, Liu JO. Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. Angew Chem Int Ed Engl 2006;45:3772-3775.
Key words: high-throughput screening, methionine aminopeptidase, X-ray structure, cell proliferation, cancer
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16724298

1. Chong CR, Qian DZ, Pan F, Wei Y, Pili R, Sullivan DJ, Liu JO. Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem 2006;49:2677-2680.
Key words: Angiogenesis, clinical drug library, screening, inosine monophosphate dehydrogenase, cancer
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16640327

1. Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J 2006;20:631-637.
Key words: blood pressure, heart rate, autonomic nervous system, nutrition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16581971

2. Yates MS, Kwak M-K, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res
2006;66:2488-2494.
Key words: chemoprevention, Nrf2, gene expression, triterpenoids, hepatocarcinogenesis
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16489057

1. Bond A, Riechart Z, Stivers JT. Novel and specific inhibitors of a pox virus family type IB topoisomerase. Mol Pharm 2006;69:547-557.
Key words: drug development, DNA topoisomerase, anti-pox agents, high-throughput screening, drug mechanism
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16267207

2. Jiang YL, Krosky DJ, Seiple L, Stivers JT. Uracil-directed ligand tethering: An efficient strategy for human uracil DNA glycosylase (UNG) inhibitor development. J Am Chem Soc 2005;127:17412-17420.
Key words: drug development, uracil DNA glycosylase, anti-HIV-1, directed inhibitor library, high-throughput inhibitor design
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16332091

3. Seiple L, Jaruga P, Dizdaroglu M, Stivers JT. Linking uracil base excision repair and 5-fluorouracil toxicity in yeast. Nucleic Acids Res 2006;30:140-151.
Key words: 5-fluorouracil, anticancer drug, chemotherapy, uracil DNA repair, drug mechanism
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16407331

1. Dinkova-Kostova AT, Holtzclaw WD, Kensler TW. The role of Keap1 in cellular protective responses. Chem Res Toxicol 2005;18:1779-1791.
Key words: Keap1, phase 2 response, Nrf2, oxidative stress, cytoprotection
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16359168

2. Fahey JW. Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties, part 1. Trees for Life Journal 2005;1:5.
Key words: Moringa, nutrition, prevention, glucosinolates, antibiotic
http://www.tfljournal.org/article.php/20051201124931586

3. Kensler TW, Chen J-G, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang J-B, Wu Y, Sun Y, Zhang Q-N, Zhang B-C, Zhu Y-R, Qian G-S, Carmella SG, Hecht SS, Benning L, Gange SJ, Groopman JD, Talalay P. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo Township, Qidong, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 2005;14:2605-2613.
Key words: glucosinolate, aflatoxin, liver cancer, clinical trial, broccoli sprouts
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16284385

4. Low WK, Dang, Y, Schneider-Poetsch T, Shi Z, Choi, NS, Merrick WC, Romo D, Liu, JO. Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Molecular Cell 2005;20:709-722.
Key words: pateamine A, translation initiation, eIF4A, stress grandule, cancer
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16337595

1. Gibson W. Assembly and maturation of the capsid. In, Cytomegaloviruses: Molecular Biology and Immunology. Ed, M. Reddehase. Horizon Scientific Press, Norwich UK. In press. (2005)
Key words: cytomegalovirus, assembly, phosphorylation, protein-protein interactions

2. Loveland AN, Chan CK, Brignole EJ, Gibson W. Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity. J Virol 2005;79:12961-12968.
Key words: cyto
megalovirus, protease, virus mutants, enzyme mechanism
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16188998


3. McCartney SA, Brignole EJ, Kolegraff KN, Loveland AN, Ussin LM, Gibson W. Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a. J Biol Chem 2005;280:33206-33212
Key words: cytomegalovirus, chemical rescue, protease, imidazole
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16036911

1. Ananthanarayanan B, Ni Q, Zhang J. Temporal control of signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proc Natl Acad Sci USA 2005;102:15081-15086.
Key words: fluorescence, FRET, PI3K, Akt, phosphoinositides
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16214892
1. Nagarajan R, Kwon K, Nawrot B, Stec WJ, Stivers JT. Catalytic phosphoryl interactions of topoisomerase 1B. Biochemistry 2005;44:11476-11485.
Key words: antiviral drugs, pox virus, topoisomerase inhibition, enzyme catalysis, phosphorothioate
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=16114884

1. Krosky DJ, Stivers JT. The origins of high affinity enzyme binding to an extrahelical DNA base. Biochemistry 2005;44:5949-5959. Key words: DNA repair, uracil DNA glycosylase, uracil flipping, inhibition
Key words: enzyme binding, DNA
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15835884

2. Vyas AA, Blixt O, Paulson JC, Schnaar RL. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro. J Biol Chem 2005;280:16305-10.
Key words: central nervous system, neurons, axon regeneration, myelin, glycan mimetics
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=1570164

1. Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress. Proc Natl Acad Sci USA 2005;102:4584-4589.
Key words: inflammation, Nrf2 Keap1, oxidative stress, phase 2 enzymes, NAD(P)H-quinone acceptor oxidoreductase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15767573

1. Cao C, Jiang YL, Song F, Stivers JT. Dynamic unpairing of DNA during the enzymatic search for a damaged base. Nature Struct Mol Biol 2004;11:1230-36.
Key words: DNA repair, Uracil DNA glycosylase, NMR structure, base dynamics
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15558051

2. Collis SJ, Schwaninger JM, Ntambi AJ, Keller TW, Nelson WG, Dillehay LE, DeWeese TL. Evasion of early cellular response mechanisms following low level radiation-induced DNA damage. J Biol Chem 2004;279:49624-32.
Key words: ionizing radiation, ataxia-telangiectasia (AT), low-dose rate
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15377658

3. DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discretesubcellular compartments. Proc Natl Acad Sci USA 2004;101:16513-18.
Key words: cAMP, Epac, PKA, FRET, compartmentation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15545605

4. Gonzalgo ML, Yegnasubramanian S, Yan G, Rogers CG, Nicol TL, Nelson WG, Pavlovich CP. Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis. Clin Cancer Res 2004;10:7276-83.
Key words: DNA methylation, CpG island, methylation profile, biomarkers, kidney cancer
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15534102

5. Hendrix CW, Collier AC, Lederman MM, Schols D, Pollard RB, Brown S, Jackson JB, Coombs RW, Glesby MJ, Flexner CW, Bridger GJ, Badel K, MacFarland RT, Henson GW, Calandra G, AMD3100 HIV Study Group. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. JAIDS 2004; 37(2):1253-1262.
Key words: chemokine receptor, HIV treatment, CXCR4 inhibition, pharmacokinetics, pharmacodynamics

6. Holtzclaw WD, Dinkova-Kostova AT, Talalay P. Protection against electrophile and oxidative stess by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers. Adv. Enzyme Regulation 2004;44:335-67.
Key words: chemoprotection against cancer, phase 2 enzyme induction, Keap1, Nrf2, antioxidant responsive element (ARE)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15581500

7. Jiang YL, McDowell L, Poliks B, Studelska DR, Cao C, Potter GS, Schaefer J, Song F, Stivers JT. Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase, Biochemistry 2004;43:15429-38.
Key words: DNA repair, uracil DNA glycosylase, NMR structure, uracil flipping
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15581354

8. Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically-encoded fluorescent reporter. J Biol Chem 2004; Dec 6; [Epub ahead of print]
Key words: kinase, PKB/Akt, FRET, fluorescent reporter, signaling
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15583002

9. Kwon K, Nagarajan R, Stivers JT. The ribonuclease activity of vaccinia DNA topoisomerase IB: presteady-state kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay. Biochemistry 2004;43:14994-15004.
Key words: topoisomerase IB, inhibition, drug screening
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15554707

10. Rogers CG, Yan G, Zha S, Gonzalgo ML, Isaacs WB, Luo J, De Marzo AM, Nelson WG, Pavlovich CP. Prostate cancer detection on urinalysis for alpha-methylacyl coenzyme A racemase protein. J Urol 2004;172:151-3.
Key words: alpha-methylacyl coenzyme A racemase, urine, antibody detection, biomarker
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15371879

1. Fahey JW, Munoz A, Matsuzaki Y, Suzuki H, Talalay P, Tauchi M, Zhang S, Hurt C, Yanaka A. Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial. Cancer Epidemiol Biomarkers Prev 2004;13:1610-6.
Key words: Helicobacter pylori, clinical trial design, diet, biomarkers, [13C]urea breath test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15466977

2. Fannjiang Y, Cheng WC, Lee SJ, Qi B, Pevsner J, McCaffery JM, Hill RB, Basañez G, Hardwick JM. Mitochondrial fission proteins regulate programmed cell death in yeast. Genes & Devel 2004 Nov 15.
Key words: yeast, apoptosis, mitochondria, Bcl-2, programmed cell death
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15520274

3. Gao X, Talalay P. Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells from photo-oxidative damage. Proc Natl Acad Sci USA 2004;101:10446-51.
Key words: antioxidants, sulforaphane, retina, photo-oxidative damage, pigment epithelial cells
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15229324

4. Hall DA, Zhu H, Zhu X, Royce T, Gerstein M, Snyder M. Regulation of gene expression by a metabolic enzyme. Science 2004 Oct 15;306:482-4.
Key words: Arg5,6, DNA binding activity, proteome chip, ChIP/chip
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15486299

5. Mager DE, Abernethy DR, Egan JM, Elahi D. Exendin-4 pharmacodynamics: Insights from the hyperglycemic clamp technique. J Pharmacol Exp Ther 2004 Nov; 311:830-835.
Key words: exendin-4, glucagon-like peptide-1, insulin clamp, pharmacodynamics
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15199095

1. Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta 2 subunit: Redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem 2004 Aug 31 [epub ahead of print].
Key words: calcium channels, regulation, splice variation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15339916

2. Kobrinsky E, Kepplinger KJF, Yu A, Harry JB, Kahr H, Romanin C, Abernethy DR, Soldatov NM. Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca channel. Biophys J 2004;87:844-857.
Key words: L-type Ca channel, Beta subunit, voltage gating
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15298893

1. Irusta PM, Lamos E, Galonek HL, Vander Maten MA, Boersma MC, Chen YB, Hardwick JM. Regulation of viruses that infect insects. Arch Virol Suppl 2004;(18):171-178.
Key words: viruses, insects, Reaper, human encephalitis virus, drosophila death gene
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15119772

2.Jiang YL, Cao C, Song F,Ichikawa Y, Stivers JT. The merits of bipartite transition-state mimics for inhibition of uracil DNA glycosylase. Bioorg Chem 2004;32:244-262.
Key words: DNA repair, glycosylase inhibition, DNA damage recognition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15210339

3. Seo SY, Chen YB, Ivanovska I, Ranger AM, Hong SJ, Dawson VL, Korsmeyer SJ, Bellows DS, Fannjiang Y, Hardwick JM. BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem 2004;Jul 1. [Epub ahead of print]
Key words: BAD, pro-apoptotic function
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15231831

4. Stivers JT. Site-specific DNA damage recognition by enzyme-induced base flipping. Prog Nucleic Acids Res Mol Biol 2004;77:37-65.
Key words: DNA damage
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15196890

1. Sagar V, Zheng W, Thompson PR, Cole PA. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorg Med Chem 2004;12: 3383-3390.
Key words: Coenzyme A, HAT, p300, mechanism, bisubstrate
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15158807

1. Akasaki K, Nakamura N, Tsukui N, Yokota S, Murata, SI, Katoh R, Michihara A, Tsuji H, Marques Jr, ETA, August JT. Human dendritic cell lysosome-associated membrane protein (hDC-LAMP) expressed in lung type II pneumocytes. Arch Biochem Biophys 2004;425:147-57.
Key words: dendritic cells, lung, lysosome, LAMP
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15111122

2. Barros de Arruda L, Chikhlikar PR, August JT, Marques Jr, ETA. DNA vaccine encoding HIV-1 Gag targeted to the MHC II compartment by lysosomal-associated membrane protein (LAMP1) elicits enhanced long-term memory response. Immunology 2004;112:126-33.
Key words: DNA vaccine, HIV-1 GAG, MHC II, lysosome, immunity
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15129672

3. Hendrix CW, Jackson KA, Whitmore E, Guidos A, Kretzer R, Liss CM, Shah LP, Khoo KC, McLane J, Trapnell CB. The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther 2004;75:464-75.
Key words: oral contraceptive, accutane, isotretinoin, pharmacodynamics, drug interaction
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15116059

4. Hines AC, Cole PA. Design, synthesis and characterization of an ATP-peptide conjugate inhibitor of protein kinase A. Bioorg Med Chem Lett 2004;14:2951-2954.
Key words: kinase, peptide, nucleotide, mechanism, bisubstrate
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15125966

5. Hwang Y, Cole PA. Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride. Org. Letters 2004;6:1555-1556.
Key words: inhibitors, prodrugs, esterases, phosphate, coenzyme A
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15128234

6. Kensler TW, Talalay P. Inducers of enzymes that protect against carcinogens: Drug and food based approaches with dithiolethiones and sulforaphane. In: Cancer Chemopreventive Agents 1: Promising Cancer Chemopreventive Agents, edited by Kelloff GJ, Hawk ET, Sigman CC., Humana Press, NJ, pp. 3-20 (2004).
Key words: diet, cancer, dithiolethiones, sulforaphane, phase 2 gene induction

7. Walser M, Thorpe B. Coping with Kidney Disease. Wiley & Sons, 2004, 230 pages.
Key words: kidney disease, kidney failure, low protein diet, amino acids, avoidance of dialysis

8. Zoete V, Rougee M, Dinkova-Kostova AT, Talalay P, Bensasson RV. Redox ranking of inducers of a cancer protective enzyme via the energy of their highest occupied molecular orbital. Free Radic Biol Med 2004;36:1418-1423.
Key words: phenylpropenoids; induction of phase 2 enzymes; molecular orbitals; HOMO
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=
Abstract&list_uids=15135178

1.Dinkova-Kostova AT, Fahey JW, Talalay P. Chemical structures of inducers of
nicotinamide quinone oxidoreductase 1 (NQ01). Methods in Enzymology 2004;382:423-448.
Key words: quinone reductase, monofunctional and bifunctional inducers, michael reaction acceptors, isothiocyanates, dithiole-3-thiones
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15047115

2. Fahey JW, Dinkova-Kostova AT, Stephenson KK, Talalay P. The "prochaska" microtiter plate bioassay for inducers of NQ01. Methods in Enzymology 2004;382:243-258.
Key words: microtiter plate bioassay, quinone reductase, Hepa 1c1c7 cells, MTT, menadione
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15047106

3. Farrell CJ, Lee JM, Shin EC, Cebrat M, Cole PA, Hayward SD. Inhibition of Epstein-barr virus induced growth proliferation by an EBNA2-TAT peptide. Proc Natl Acad Sci USA 2004;101:4625-4630.
Key words: peptide, CBF1, notch, transformation, EBNA2
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15070768

4. Krosky DJ, Schwarz FP, Stivers JT. Linear free energy correlations for enzymatic base flipping: How do damaged base pairs facilitate specific recognition? Biochemistry 2004;43:4188-4195.
Key words: base flipping, uracil DNA glycosylase, base excision repair, DNA damage recognition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15065862

5. Talalay P, Dinkova-Kostova AT. Role of nicotinamide quinone oxidoreductase 1 (NQ01) in protection against toxicity of electrophiles and reactive oxygen intermediates. Methods in Enzymology 2004:382;355-363.
Key words: quinone reductase, electrophiles, ARE, anticarcinogens, cancer
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15047111

6. Thompson PR, Wang D, Wang L, Fulco M, Pediconi N, Zhang D, An W, Ge Q, Roeder RG, Wong J, Levrero M, Sartorelli V, Cotter RJ, Cole PA. Regulation of p300 HAT domain via a novel activation loop. Nature Struct Mol Biol 2004;11:308-315.
Key words: histone, acetyltransferase, enzyme, mass spec, lysine
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=15004546

[Commentary: Nature Struct Mol Biol 2004;10:298-300.]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&lis_uids=15048100

7. Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 2004;101:2040-2045.
Key words: sulfhydryl groups, phase 2 enzymes, ARE, Nrf2, Keap1
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14764894

8. Zheng Y, Thompson PR, Cebrat M, Wang L, Devlin MK, Alani RM, Cole PA. Selective HAT inhibitors as mechanistic tools for protein acetylation. Meth Enz 2004;376:188-199.
Key words: histone, acetyltransferase, chromatin, transcription, gene regulation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14975306

1. Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. J Med Chem 2004 Feb 26;47(5):1299-301.
Key words: malaria, plasmodium, trioxane, antimalarial, chemotherapy
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=
pubmed&dopt=Abstract&list_uids=14971910
1. Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR. Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther 2004;75:60-69.
Key words: abciximab, pharmacodynamics, neural network, platelets
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=
14749692&dopt=Abstract



01/04

1. Cole PA, Shen K, Qiao Y, Wang D. Protein tyrosine kinases Src and Csk: A tail's tale. Curr Opin Chem Biol 2003;7:580-5.
Key words: Src, Csk, kinase, protein, signaling
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14580561&dopt=Abstract

2. Mager DE, Mascelli MA, Kleiman NS, Fitzgerald DJ, Abernethy DR. Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty. J Pharmacol Exp Ther 2003;307:969-76.
Key words: pharmacokinetic-pharmacodynamic modeling, abciximab, coronary angioplasty
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14534354&dopt=Abstract

3. Nagababu E, Ramasamy S, Abernethy DR, Rifkind JM. Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin mediated nitrite reduction. J Biol Chem 2003;278:46349-56,2003.
Key words: nitric oxide, nitrite, deoxyhemoglobin
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12952953&dopt=Abstract

4. Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner CW, Alper SL, Lencer WI. Diarrhea-associated HIV-1 aspartyl protease-inhibitors potentiate muscarinic Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Am J Physiol Cell Physiol 2003 Dec 30;[Epub ahead of print].
Key words: nelfinavir, HIV protease inhibitors, calcium homeostasis, secretory diarrhea, adverse drug effects
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14701666&dopt=Abstract

5. Shen K, Cole PA. Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage. J Am Chem Soc 2003;125:16172-3.
Key words: kinase, phosphorylation, ATP, bisubstrate analog, Src
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14692742&dopt=Abstract

6. Thayer JF, Merritt MM, Sollers JJ, Zonderman AB, Evans MK, Yie S, Abernethy DR. Effect of angiotensin converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans. Am J Cardiol 2003;92:1487-90.
Key words: angiotensin converting enzyme insertion/deletion polymorphism, African-American, heart rate variability
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14675596&dopt=Abstract

7. Zheng W, Zhang Z, Ganguly, S, Weller, JL, Klein D, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by non-hydrolyzable phosphonate incorporation. Nature Structural Biology 2003;10:1054-7.
Key words: circadian rhythm, melatonin, 14-3-3, phosphorylation, phosphonate
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14578935&dopt=Abstract

1. Benson CA, Williams PL, Currier JS, Holland F, Mahon LF, MacGregor RR,Inderlied CB, Flexner C, Neidig J, Chaisson R, Notario GF, Hafner R. A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons
with acquired immunodeficiency syndrome. Clin Infect Dis 2003 Nov 1;7(9):1234-43.
Key words: mycobacteria, treatment trials, HIV, tuberculosis, rifabutin
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=14557969&dopt=Abstract

2. Cao C, Kwon K, Jiang YL, Stivers JT. Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I. J Biol Chem 2003;278:48012-48020.
Key words: DNA repair, 3-methyladenine, DNA glycosylase, NMR solution structure, enzymology
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_ui
ds=13129925&dopt=Abstract

3. Katz J, Feldman MA, Bass EB, Lubomski LH, Tielsch JM, Petty BG, Fleisher LA, Schein OD. Risks and benefits of anticoagulant and antiplatelet medication use before cataract surgery. Ophthalmology 2003;110:1784-1788.
Key words: anticoagulation, warfarin, aspirin, cataract surgery, postoperative complications
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=13129878&dopt=Abstract

4. Kwak MK, Wakabayashi N, Greenlaw, JL, Yamamoto M, Kensler TW. Antioxidants
enhance mammalian proteasome expression through the Keap1/Nrf2 signaling
pathway. Mol Cell Biol 2003;23:8786-8794.
Key words: antioxidants, proteasome, induction, Nrf2
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=14612418&dopt=Abstract

1. Bianchet MA, Seiple L, Jiang YL, Ichikawa Y, Amzel LM, Stivers JT.Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase. Biochemistry 2003;42:12455-12460. (accelerated publication).
Key words: DNA repair, uracil DNA glycosylase, transition-state inhibitor, 1-azadeoxyribose, crystal structure
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14580190&dopt=Abstract

1. Bakshi RP, Shapiro TA. DNA topoisomerases as targets for antiprotozoal therapy. Mini Rev Med Chem 2003;6:597-608.
Key words: Drug discovery, topoisomerase, protozoa, enzyme inhibitors
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12871162&dopt=Abstract

2. Davies A, Kalb S, Liang B, Aldrich CJ, Lemonnier FA, Jiang H, Cotter RJ, Soloski MJ. A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class 1a leader sequence peptide Qdm. J Immunol 2003;170:5027-5033.
Key words: peptide, MHC class 1a, heat shock protein
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12734347&dopt=Abstract

3. Moyer SC, Von Seggern CE, Cotter RJ. Fragmentation of cationized phosphotyrosine containing peptides by atmospheric pressure MALDI/ion trap mass spectrometry. J Am Soc Mass Spectrom 2003;14:581-592.
Key words: AP MALDI, infrared MALDI, phosphotyrosine, peptide fragmentation, ion trap mass spectrometry
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12781459&dopt=Abstract

4. Nenortas E, Kulikowicz T, Burri C, Shapiro TA. Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions. Antimicrob Agents Chemother 2003;47:3015-3017.
Key words: African trypanosome, trypanosomes, fluoroquinolones, drug discovery, topoisomerases
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12937017&dopt=Abstract

5. Violin JD, Zhang J, Tsien, RY, Newton,AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol 2003;161:899-909.
Key words: PKC, phosphorylation, FRET, calcium, oscillation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12782683&dopt=Abstract

6. Von Seggern CE, Cotter RJ. Fragmentation studies of non-covalent sugar-sugar complexes by infrared atmospheric pressure MALDI. J Am Soc Mass Spectrom 2003;14:1158-1165.
Key words: AP MALDI, infrared MALDI, non-covalent complexes, oligosaccharides, carbohydrates
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=14530096&dopt=Abstract

7. Von Seggern CE, Moyer SC, Cotter RJ. Liquid infrared atmospheric pressure MALDI/ion trap mass spectrometry of sialylated oligosaccharides. Annal Chem 2003;75:3212-3218.
Key words: AP MALDI, infrared MALDI, sialic acid, oligosaccharides, ion trap mass spectrometry
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12964771&dopt=Abstract

1. Dimick JB, Swoboda S, Talamini MA, Pelz RK, Hendrix CW, Lipsett PA. Risk of colonization of central venous catheters: catheters for total parenteral nutrition vs other catheters. Am J Crit Care 2003;4:328-335.
Key words: central venous catheter, colonization of central venous catheters, parenteral nutrition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12882063&dopt=Abstract

2. Zheng W, Cole PA. Novel bisubstrate analog inhibitors of serotoninn-acetyltransferase: The importance of being neutral. Bioorg Chem 2003;31:398-411.
Key words: melatonin, inhibitors, enzyme mechanism, transition state, pKa
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12941292&dopt=Abstract

1. Cebrat M, Kim CM, Thompson PR, Daugherty M, Cole PA. Synthesis and analysis of potential prodrugs of coenzyme A analogs for the inhibition of histone acetyltransferase p300. Bioorg Med Chem 2003;11:3307-3313.
Key words: HATs, transcription, chromatin, GCN5, PCAF
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12837541&dopt=Abstract

2. Cole PA, Courtney AD, Zhang Z, Qiao Y, Lu W, Williams DM. Chemical approaches to reversible protein phosphorylation. Acc Chem Res 2003;36:444-452.
Key words: kinase, phosphatase, chemical rescue, crosslinking, protein ligation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12809531&dopt=Abstract

3. Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation of Tat defines a cyclin T1-independent step in HIV transactivation. Mol Cell 2003;12:167-176.
Key words: HIV, Tat, p300, Lys-CoA, transcription
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12887902&dopt=Abstract

4. Stivers JT, Jiang YL. A mechanistic perspective on the chemistry of DNA repair glycosylases. Chem Rev 2003;103:2729-2759.
Key words: DNA repair, DNA glycosylase, nucleoside chemistry, enzyme mechanism, DNA damage recognition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12848584&dopt=Abstract

1. Bodley AL, Chakraborty AK, Xie S, Burri C, Shapiro TA. An unusual type IB topoisomerase from African trypanosomes. Proc Natl Acad Sci USA 2003;100(13):7539-7544.
Key words: sleeping sickness, topoisomerase, drug discovery, DNA synthesis, inhibitors
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12810956&dopt=Abstract

2. Kwon K, Cao C, Stivers JT. A novel "zinc snap" motif conveys structural stability to 3-methyladenine DNA glycosylase I. J Biol Chem 2003;278(21):19442–6.
Key words: DNA repair, zinc snap, DNA alkylation, 3-methyladenine DNA glycosylase, heteronuclear NMR
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12654914&dopt=Abstract

3. Moyer SC, Von Seggern CE, Cotter RJ. Fragmentation of cationized phosphotyrosine containing peptides by atmospheric pressure MALDI/Ion trap mass spectrometry. JASMS 2003;14:581-92.
Key words: mass spectrometer, phosphorylated peptides, ion trap, AP MALDI, phosphotyrosine
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12781459&dopt=Abstract

4. Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimmers with high stability and efficacy. J Med Chem 2003; 46(6):1060-5.
Key words: malaria, chemotherapy, artemisinins, synthetic trioxanes, drug discovery
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12620083&dopt=Abstract

5. Rajagopalan P, Pelz RK, Lipsett PA, Swoboda SM, Rinaldi MG, Hendrix CW. Enteral fluconazole population pharmacokinetics in patients in the surgical intensive care unit. Pharmacotherapy 2003; 23(5):592-602.
Key words: fluconazole, critically ill, population pharmacokinetics, anti-fungal, pharmacokinetics
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12741433&dopt=Abstract

6. Scheibner KA, Zhang Z, Cole P A. Merging FRET and expressed protein ligation to analyze protein-protein interactions. Annal Biochem 2003;317:226-32.
Key words: fluorescein, rhodamine, dimer, acetyltransferase, monomer
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12758261&dopt=Abstract

7. Stivers JT, Jiang YL. A mechanistic perspective on the chemistry of DNA repair glycosylases. Chem Rev 2003;103(7):272-60.
Key words: DNA repair, DNA glycosylase, nucleoside chemistry, enzyme mechanism, DNA damage recognition
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12848584&dopt=Abstract

8. Washington CB, Flexner C, Sheiner LB, Rosenkranz SL, Segal Y, Aberg JA, Blaschke TF. Effect of simultaneous versus staggered dosing on pharmacokinetic interactions of protease inhibitors. Clin Pharmacol Ther 200;73(5):406-16.
Key words: HIV, protease inhibitors, drug metabolism
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12732841&dopt=Abstract

1. Cotter RJ, English RD, Warscheid B, Hardy A, Gardner BD. Miniaturized time-of-flight mass spectrometers for bioagent detection and identification. J Mass Spectrom Soc Japan 2003; 51:36-41.
Key words: time-of-flight, miniaturized time-of-flight, mass spectrometers, bioagent detection

2. Georges SA, Giebler HA, Cole PA, Luger K, Laybourn PJ, Nyborg JK. Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent. Mol Cell Biol 2003; 23(10): 3392-404.
Key words: acetyltransferase, hat, tax, HTLV-I, transcription
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12724399&dopt=Abstract

3. Hamzeh FM, Benson C, Gerber J, Currier J, McCrea H, Deutsch P, Ruan P, Wu H, Lee J, Flexner C. Steady-state phamacokinetic interaction of modified-dose indinavir and rifabutin. Clin Pharmacol Ther 2003; 73 (3): 159-69.
Key words: indinavir, protease inhibitor, drug interaction, rifabutin
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12621381&dopt=Abstract

4. Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Nature 2003 Apr 17; 422 (6933): 730-4.
Key words: myocyte enhancer factor 2, Cabin1/cain, thymocyte apoptosis, calcium signaling, heart hypertrophy
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12700764&dopt=Abstract

5. Huang ZQ, Li J, Sachs LM, Cole PA, Wong J. A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and mediator for transcription. EMBO J 2003 May 1; 22 (9): 2146-2155.
Key words: acetyltransferase, hat, histone, inhibitor, chromatin
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12727881&dopt=Abstract

6. Jackson JB, Barnett S, Piwowar-Manning E, Apuzzo L, Raines C, Hendrix C, Hamzeh F, Gallant J. A phase I/II study of nevirapine for pre-exposureprophylaxis of HIV-1 transmission in uninfected subjects at high risk. AIDS 2003 Mar 7; 17 (4): 547-53.
Key words: nevirapine, prophylaxis, AIDS, HIV
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12598775&dopt=Abstract

7. Jiang YL, Stivers JT. Epimerization of aromatic C-nucleosides with electron-withdrawing substituents with trifluoroacetic acid-benzenesulfonic acid using mild conditions. Tetrahedron Lett 2003; 44: 4051-4055.
Key words: DNA repair, C-nucleosides, uracil DNA glycosylase, epimerization, nucleoside analogues

8. Kwon K, Jiang Y L, Stivers JT Rational engineering of a DNA glycosylase specific for unnatural cytosine: pyrene base pairs. Chem and Biol 2003; 10: 351-359.
Key words: DNA glycosylase, enzyme engineering, single nucleotide, polymorphism detection, mutagenesis, substrate rescue
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12725863&dopt=Abstract

9. Lee KC, Li J, Cole PA, Wong J, Kraus WL. Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergisticstimulation by p300 and steroid receptor coactivators. Mol Endocrinol 2003; 17 (5): 908-22.
Key words: histone, hat, lys-CoA, CBP, acetyltransferase
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12586842&dopt=Abstract

10. Lu W, Shen K, Cole PA. Chemical dissection of the effects of tyrosine phosphorylation of SHP-2. Biochemistry 2003 May 13; 42 (18): 5461-8.
Key words: phosphatase, shp-2, protein, peptide, ligation
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12731888&dopt=Abstract

11. Lu Y, Raviprakash K, Leao IC, Chikhlikar PR, Ewing D, Anwar A, Chougnet C, Murphy G, Hayes CG, August JT, Marques ETA. Dengue 2 PreM-E/LAMP chimera targeted to the MHC class II compartment elicits long-lasting neutralizing antibodies. Vaccine 2003; 21: 2187-2198.
Key words: DNA vaccine, LAMP trafficking, lysosome membrane protein, dengue vaccine, adjuvant
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&
db=PubMed&list_uids=12706709&dopt=Abstract

1. Kwak, MK, Wakabayashi, N, Itoh, K, Motohashi, H, Yamamoto, M and Kensler, TW. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1- and Nrf2 pathway: Identification of novel gene clusters for cell survival. J Biol Chem 2003; 278: 8135-8145.
Key words: Nrf2, microarray, proteosome, phase 2 enzymes, antioxidants
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12570336&dopt=Abstract

2. Que-Gewirth, NLS, Karbarz, MJ, Kalb, SR, Cotter, RJ and Raetz, CRH. Origin of the 2-aminogluconante Unit in Rhizobium Leguminosarum Lipid A: Expression cloning of the Outer Membrane Oxidase LpxQ. J. Biol. Chem. 2003; 278:12120-12129.
Key words: Rhizobium, LpxQ, Oxidase, Lipid A, outer membrane
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
&db=PubMed&list_uids=12531908&dopt=Abstract

3. Ramos-Gomez M, Dolan PM, Itoh K, Yamamoto M, Kensler TW. Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 2003; 24:461-467.
Key words: chemoprevention, carcinogenesis, Nrf2, DNA adducts, knockout mice
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve
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