Images of our Work:
Mehta
, et al., J Biol Chem 282, Epub ahead of press (2007)Left: Dorsal root ganglion neurons labeled with anti-tubulin
antibody. Top, control; Bottom, inhibited by myelin-associated glycoprotein
(MAG).
Right: MAG inhibits axon outgrowth via two independent pathways.
Gong, et al., Brain 125, 2491-2506 (2002)
Dorsal root ganglia triple-labelled with anti-ganglioside mAbs (green), neurofilament (red) and IB-4 (blue). Co-localization of three labels is also shown (Merged). The mAbs included in this figure are shown on the left. Bar = 20 mm.
Lunn, et al., J. Neurochem. 75, 404-412 (2000)
Gangliosides on neurons in cell culture. Rat cerebellar granule neurons immunostained with anti-GD1a antibody (left). Corresponding Hoffman modulation contrast image (right). Asterisk denotes non-neuronal cells, which fail to stain.
Sheikh, et al., Proc. Natl. Acad. Sci. USA 96, 7532-7537 (1999)
Axon degeneration (left) and demyelination (right) in "complex ganglioside" knockout mice
Tiemeyer, et al., J. Biol. Chem. 265, 11990-11999 (1990).
Binding of radiolabeled ganglioside ligand to receptors in the rat brain. Left: Rat brain section stained with cresyl violet. Right: Adjacent section treated with 125I-GT1b-BSA, washed, and subjected to autoradiography. Note prominent white matter but not gray matter distribution of ganglioside receptors.
Weisz and Schnaar, J. Cell Biol. 115, 485-493 (1991)
Confocal immunolocalization of the hepatic lectin on the surface of rat hepatocytes adhering to galactose-derivatized surfaces
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