Current Projects:

Glycans and glycan-binding proteins in inflammatory lung diseases

Identify human lung counter-receptors for Siglec-8 and their role in eosinophilic lung inflammation

Identify human lung counter-receptors for Siglec-9 and their role in neutrophilic lung inflammation

Coordinate with other LIDPEG projects to test the roles of siglec counter-receptors in the control of lung inflammatory diseases

Ganglioside function in the brain

Using mice genetically engineered to lack complex gangliosides study the roles of brain gangliosides in .....

The control of AMPA subtype glutamate receptor trafficking, excitatory neurotransmission and cognition

Nerve degeneration and dysmyelination

Motor behavioral deficits

HIV-Tat and HIV-associated neurocognitive disorders

Determine the chemical basis for the highly potent neurotoxicity of mammalian-expressed HIV-Tat

Determine the mechanisms by which HIV-Tat causes neurotoxicity

Support structural studies of HIV-Tat assocaition with NMDA subtype glutamate receptors

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