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Latest in Research
Researchers at Johns Hopkins are constantly advancing science through basic, translational and clinical investigations. Here are highlights of our most current findings.
One in five patients prescribed antibiotics experience side effects
A new study on hospitalized adults adds to growing evidence that antibiotics are not benign and that clinicians often fail to weigh both the risks and benefits of antibiotics before prescribing them.Learn more
Flaws in genetic mending kit drive response to immunotherapy drug
A three-year clinical trial of patients with 12 different kinds of cancer with so-called ‘mismatch repair’ genetic defects found that half responded to a drug called pembrolizumab. The findings led the U.S. Food and Drug Administration to approve expanded use of pembrolizumab for patients, the researchers also say they found evidence that the immune responses closely aligned with mutations found in their cancers. The report is published online in the June 8 issue of the journal Science.Learn more
Double-duty nanoparticles lower cancer's defenses while firing up the immune system
The new nanoparticle carries two different antibodies that simultaneously switch off cancer cells’ defensive properties while switching on a robust anticancer immune response in mice, dramatically slowing the growth of mouse melanoma and colon cancer.Learn more
Most Cancer Mutations are Due to Random DNA Copying ‘Mistakes’
Johns Hopkins Kimmel Cancer Center scientists report data from a new study providing evidence that random, unpredictable DNA copying “mistakes” account for nearly two-thirds of the mutations that cause cancer. Their research is grounded on a novel mathematical model based on DNA sequencing and epidemiologic data from around the world.Learn more
Novel gene therapy offer hope for people with certain hearing loss and dizziness disorders
In a first-of-its-kind study, researchers using gene therapy were able to restore balance and hearing in mice breed to have a disease that mimics Usher Syndrome, a genetic condition in humans characterized by partial or total hearing loss and vision loss that worsens over time.Learn more
City Living Can Make Asthma Worse for Poor Children
Results of a new study by researchers using national data add to evidence that living in inner cities can worsen asthma in poor children. Children who lived in inner-city areas had an overall 40 percent higher risk of asthma-related emergency room visits and 62 percent higher risk of asthma-related hospitalizations.Learn more
Hepatitis C Mutations ‘Outrun’ Our Immune Systems
Unlike its cousins hepatitis A and B, hepatitis C (HCV) has eluded vaccine development. Researchers have developed a tool that finds virus mutations faster and more efficiently than ever before. They have identified a biological mechanism that appears to play a role in helping HCV evade the immune system.Learn more
Making ‘The Pill’ Available Over-the-Counter
After reviewing decades of published studies, a team of pediatric, adolescent and women’s health experts concludes that regulatory, behavioral and scientific evidence supports switching oral contraceptives from prescription-only status to over-the-counter (OTC) availability.Learn more
The design for the first fully synthetic yeast genome is now complete, and international consortium of researchers announced. The genome is expected to both speed biological research and make it easier to use yeast to make medications and other products.Learn more
A new study showed that professional pest management was no better in decreasing asthma allergy symptoms in children allergic to mice than teaching families do-it-yourself methods of mouse allergen reduction. The findings suggest that giving families good instructions on how to reduce mouse allergies that trigger asthma in children may be enough to reduce allergen levels and improve asthma symptoms.Learn more
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