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School of Medicine
Latest in Research
Researchers at Johns Hopkins are constantly advancing science through basic, translational and clinical investigations. Here are highlights of our most current findings.
Breast Cancer Risk? There’s an App for That
A free, web-based app could take some of the guesswork out of doctors’ decision whether to order a costly molecular test for women with early stage breast cancer that estimates the risk of recurrence.Read more.
Altering the ‘Flavor’ of Humans Could Help Fight Malaria
New research suggests that a specialized area of the mosquito brain mixes tastes with smells to create unique and preferred flavors. The findings bring scientists closer to identifying a substance that makes humans’ flavor repulsive to malaria-bearing mosquitoes.Read more.
Brain Cell ‘Executioner’ Identified
Surprisingly, strokes, brain injuries and neurodegenerative diseases like Alzheimer’s cause brain cell death through the same molecular chain of events. Now, researchers have pinpointed the protein at the end of that chain, potentially spurring new ideas for the development of drugs to prevent, stop or weaken the process.Read more.
Link Between Zika Infection, Guillain-Barré Syndrome
Collaborating with hospitals in Colombia, researchers tested 42 patients with the rare but potentially paralyzing Guillain-Barré syndrome for evidence of Zika virus infection. Thirty-five, or 83 percent, tested positive for Zika, providing strong evidence that the two are linked.Learn more.
Three Existing Drugs May Fight Zika Infections
By testing 6,000 existing drugs for their ability to stop the Zika virus from multiplying in lab-grown human cells, scientists found three compounds that show promise and will continue to be tested as possible treatments for the virus.Learn more.
No Bread Crumbs? No Problem.
Neuroscientists have figured out how some mammals’ brains solve certain navigational problems. If there’s a reward at the end of a trip, like a chocolatey drink for the rats in their study, specialized neurons in the hippocampus of the brain “replay” the route taken to get there, but backward.Learn more.
Treatment Clues Come from Tracking Cancer Cells’ Energy Usage
Combinations of anti-cancer drugs often work better than single drug treatments. Now scientists might be able to better predict which combinations will work best, using a method that tracks the energy usage of cancer cells to reveal their drug-specific vulnerabilities.Learn more.
Really Low Blood Pressure Can Be Bad, Too
Most treatments for high blood pressure aim to lower the “top number,” but also lower the bottom number—a measure of pressure in the arteries between heartbeats. A new analysis of medical records from more than 11,000 Americans suggests that driving that number below 80 might damage heart tissue.Learn more.
Most Copies of HIV “in Hiding” Are Harmless
By sequencing so-called dormant copies of the HIV virus in 19 people undergoing treatment for AIDS, scientists discovered that the most commonly used method for measuring the hidden viruses identifies mostly defective ones, rather than those that can spring back into action and keep infections going.Read more.
Faulty Chromosome Capping Linked to Inherited Lung Disease
Researchers have identified a gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis. The mutation, which effects the protective caps on chromosomes’ ends, also leaves patients hypersensitive to several relevant medications.Read more.
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