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Jiang Qian, M.S., Ph.D.

Photo of Dr. Jiang Qian, M.S., Ph.D.

Associate Professor of Ophthalmology

Research Interests: Retinal gene regulation

Contact for Research Inquiries

Smith Building
400 N. Broadway
Baltimore, MD 21287 map
Phone: 443-287-3882

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Background

Jiang Qian, Ph.D., is an associate professor of ophthalmology at the Wilmer Eye Institute. His research focuses on retinal gene regulation and the application of bioinformatics to the study of gene expression and regulation.

Dr. Qian received an M.S. in computational biology from Shanghai Biochemistry Institute in Shanghai, China, and a Ph.D. in physical chemistry from the Max Planck Institute for Polymer Research in Mainz, Germany. He then completed a postdoctoral fellowship in bioinformatics at Yale University.

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Titles

  • Associate Professor of Ophthalmology
  • Associate Professor of Oncology

Departments / Divisions

Education

Degrees

  • B.S., Shanghai Jiaotong University School of Medicine (China) (1991)
  • M.S., Shanghai Institute of Biochemistry - Shanghai (China) (1994)
  • Ph.D., Max Planck Institute (Germany) (1999)

Additional Training

Yale University, New Haven, Connecticut, 2001, Bioinformatics

Research & Publications

Research Summary

We are working on a number of research projects that all are related to applying bioinformatics approaches to the study of gene regulation, with particular but not exclusive attention to the regulation of retinal gene expression. We have performed large-scale computational analysis of transcription factor (TF) interactions both in the yeast S. cerevisiae and human tissues. The identified TF interactions can help in our understanding of gene regulation and tissue specificity in eukaryotic systems. In a recent project, we collaborated with Drs. Heng Zhu and Seth Blackshaw’s labs to work on large-scale identification of human protein-DNA interactions.

We are also interested in studying aspects of post-transcriptional gene regulation. In one project our analysis generated data that suggests that the interaction patterns between TFs and microRNAs can influence the biological functions of microRNAs.

Another area that we are studying concerns epigenetic gene regulation. We took advantage of available genome wide data sets of nucleosome positions to analyze the rules that determine nucleosome positioning, and their effects on biological functions.

Lab Website: Wilmer Bioinformatics

Selected Publications

View all on Pubmed

  1. Xie, Z.; Hu, S.; Blackshaw, S.; Zhu, H.; Qian, J. hPDI: a database of experimental human protein-DNA interactions. Bioinformatics. 2010 Jan 15;26(2):287-289.
  2. Lin, J.; Xie, Z.; Zhu, H.; Qian, J. Understanding protein phosphorylation on a systems level. Brief Funct Genomics. 2010 Jan;9(1):32-42.
  3. Wan, J.; Lin, J.; Zack, D.J.; Qian, J. Relating periodicity of nucleosome organization and gene regulation. Bioinformatics. 2009 Jul 15;25(14):1782-1788.
  4. Lin, Y.Y.; Lu, J.Y.; Zhang, J.; Walter, W.; Dang, W.; Wan, J.; Tao, S.C.; Qian, J.; Zhao, Y.; Boeke, J.D.; Berger, S.L.; Zhu, H. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar 20;136(6):1073-1084.
  5. Kung, L.A.; Tao, S.C.; Qian, J.; Smith, M.G.; Snyder, M.; Zhu, H. Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes. Mol Syst Biol. 2009;5:308.
  6. Hu, S.; Xie, Z.; Onishi, A.; Yu, X.; Jiang, L.; Lin, J.; Rho, H.S.; Woodard, C.; Wang, H.; Jeong, J.S.; Long, S.; He, X.; Wade, H.; Blackshaw, S.; Qian, J.; Zhu, H. Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 2009 Oct 30;139(3):610-622.
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